ICU-Admission Hyperphosphataemia Is Related to Shock and Tissue Damage, Indicating Injury Severity and Mortality in Polytrauma Patients
Hyperphosphataemia can originate from tissue ischaemia and damage and may be associated with injury severity in polytrauma patients. In this retrospective, single-centre study, 166 polytrauma patients (injury severity score (ISS) ≥ 16) primarily requiring intensive care unit (ICU) treatment were ana...
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| Format: | Article |
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MDPI AG
2021-08-01
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| Series: | Diagnostics |
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| Online Access: | https://www.mdpi.com/2075-4418/11/9/1548 |
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| author | Christopher Rugg Mirjam Bachler Robert Kammerlander Daniel Niederbrunner Johannes Bösch Stefan Schmid Janett Kreutziger Mathias Ströhle |
| author_facet | Christopher Rugg Mirjam Bachler Robert Kammerlander Daniel Niederbrunner Johannes Bösch Stefan Schmid Janett Kreutziger Mathias Ströhle |
| author_sort | Christopher Rugg |
| collection | DOAJ |
| description | Hyperphosphataemia can originate from tissue ischaemia and damage and may be associated with injury severity in polytrauma patients. In this retrospective, single-centre study, 166 polytrauma patients (injury severity score (ISS) ≥ 16) primarily requiring intensive care unit (ICU) treatment were analysed within a five-year timeframe. ICU-admission phosphate levels defined a hyperphosphataemic (>1.45 mmol/L; <i>n</i> = 56) opposed to a non-hyperphosphataemic group (<i>n</i> = 110). In the hyperphosphataemic group, injury severity was increased (ISS median and IQR: 38 (30–44) vs. 26 (22–34); <i>p</i> < 0.001), as were signs of shock (lactate, resuscitation requirements), tissue damage (ASAT, ALAT, creatinine) and lastly in-hospital mortality (35.7% vs. 5.5%; <i>p</i> < 0.001). Hyperphosphataemia at ICU admission was shown to be a risk factor for mortality (1.46–2.10 mmol/L: odds ratio (OR) 3.96 (95% confidence interval (CI) 1.03–15.16); <i>p</i> = 0.045; >2.10 mmol/L: OR 12.81 (CI 3.45–47.48); <i>p</i> < 0.001) and admission phosphate levels alone performed as good as injury severity score (ISS) in predicting in-hospital mortality (area under the ROC curve: 0.811 vs. 0.770; <i>p</i> = 0.389). Hyperphosphataemia at ICU admission is related to tissue damage and shock and indicates injury severity and subsequent mortality in polytrauma patients. Admission phosphate levels represent an easily feasible yet strong predictor for in-hospital mortality. |
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| issn | 2075-4418 |
| language | English |
| last_indexed | 2024-03-10T07:46:36Z |
| publishDate | 2021-08-01 |
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| record_format | Article |
| series | Diagnostics |
| spelling | doaj.art-9243a2c3b5ba4dba844d88a866b3414a2023-11-22T12:38:33ZengMDPI AGDiagnostics2075-44182021-08-01119154810.3390/diagnostics11091548ICU-Admission Hyperphosphataemia Is Related to Shock and Tissue Damage, Indicating Injury Severity and Mortality in Polytrauma PatientsChristopher Rugg0Mirjam Bachler1Robert Kammerlander2Daniel Niederbrunner3Johannes Bösch4Stefan Schmid5Janett Kreutziger6Mathias Ströhle7Department of Anaesthesiology and Critical Care Medicine, Medical University of Innsbruck, Anichstrasse 35, 6020 Innsbruck, AustriaDepartment of Anaesthesiology and Critical Care Medicine, Medical University of Innsbruck, Anichstrasse 35, 6020 Innsbruck, AustriaDepartment of Anaesthesiology and Critical Care Medicine, Medical University of Innsbruck, Anichstrasse 35, 6020 Innsbruck, AustriaDepartment of Anaesthesiology and Critical Care Medicine, Medical University of Innsbruck, Anichstrasse 35, 6020 Innsbruck, AustriaDepartment of Anaesthesiology and Critical Care Medicine, Medical University of Innsbruck, Anichstrasse 35, 6020 Innsbruck, AustriaDepartment of Anaesthesiology and Critical Care Medicine, Medical University of Innsbruck, Anichstrasse 35, 6020 Innsbruck, AustriaDepartment of Anaesthesiology and Critical Care Medicine, Medical University of Innsbruck, Anichstrasse 35, 6020 Innsbruck, AustriaDepartment of Anaesthesiology and Critical Care Medicine, Medical University of Innsbruck, Anichstrasse 35, 6020 Innsbruck, AustriaHyperphosphataemia can originate from tissue ischaemia and damage and may be associated with injury severity in polytrauma patients. In this retrospective, single-centre study, 166 polytrauma patients (injury severity score (ISS) ≥ 16) primarily requiring intensive care unit (ICU) treatment were analysed within a five-year timeframe. ICU-admission phosphate levels defined a hyperphosphataemic (>1.45 mmol/L; <i>n</i> = 56) opposed to a non-hyperphosphataemic group (<i>n</i> = 110). In the hyperphosphataemic group, injury severity was increased (ISS median and IQR: 38 (30–44) vs. 26 (22–34); <i>p</i> < 0.001), as were signs of shock (lactate, resuscitation requirements), tissue damage (ASAT, ALAT, creatinine) and lastly in-hospital mortality (35.7% vs. 5.5%; <i>p</i> < 0.001). Hyperphosphataemia at ICU admission was shown to be a risk factor for mortality (1.46–2.10 mmol/L: odds ratio (OR) 3.96 (95% confidence interval (CI) 1.03–15.16); <i>p</i> = 0.045; >2.10 mmol/L: OR 12.81 (CI 3.45–47.48); <i>p</i> < 0.001) and admission phosphate levels alone performed as good as injury severity score (ISS) in predicting in-hospital mortality (area under the ROC curve: 0.811 vs. 0.770; <i>p</i> = 0.389). Hyperphosphataemia at ICU admission is related to tissue damage and shock and indicates injury severity and subsequent mortality in polytrauma patients. Admission phosphate levels represent an easily feasible yet strong predictor for in-hospital mortality.https://www.mdpi.com/2075-4418/11/9/1548hyperphosphatemiaphosphateICUpolytrauma |
| spellingShingle | Christopher Rugg Mirjam Bachler Robert Kammerlander Daniel Niederbrunner Johannes Bösch Stefan Schmid Janett Kreutziger Mathias Ströhle ICU-Admission Hyperphosphataemia Is Related to Shock and Tissue Damage, Indicating Injury Severity and Mortality in Polytrauma Patients Diagnostics hyperphosphatemia phosphate ICU polytrauma |
| title | ICU-Admission Hyperphosphataemia Is Related to Shock and Tissue Damage, Indicating Injury Severity and Mortality in Polytrauma Patients |
| title_full | ICU-Admission Hyperphosphataemia Is Related to Shock and Tissue Damage, Indicating Injury Severity and Mortality in Polytrauma Patients |
| title_fullStr | ICU-Admission Hyperphosphataemia Is Related to Shock and Tissue Damage, Indicating Injury Severity and Mortality in Polytrauma Patients |
| title_full_unstemmed | ICU-Admission Hyperphosphataemia Is Related to Shock and Tissue Damage, Indicating Injury Severity and Mortality in Polytrauma Patients |
| title_short | ICU-Admission Hyperphosphataemia Is Related to Shock and Tissue Damage, Indicating Injury Severity and Mortality in Polytrauma Patients |
| title_sort | icu admission hyperphosphataemia is related to shock and tissue damage indicating injury severity and mortality in polytrauma patients |
| topic | hyperphosphatemia phosphate ICU polytrauma |
| url | https://www.mdpi.com/2075-4418/11/9/1548 |
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