Integration of enabling methods for the automated flow preparation of piperazine-2-carboxamide
Here we describe the use of a new open-source software package and a Raspberry Pi® computer for the simultaneous control of multiple flow chemistry devices and its application to a machine-assisted, multi-step flow preparation of pyrazine-2-carboxamide – a component of Rifater®, used in the treatmen...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Beilstein-Institut
2014-03-01
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| Series: | Beilstein Journal of Organic Chemistry |
| Subjects: | |
| Online Access: | https://doi.org/10.3762/bjoc.10.56 |
| _version_ | 1818870614389161984 |
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| author | Richard J. Ingham Claudio Battilocchio Joel M. Hawkins Steven V. Ley |
| author_facet | Richard J. Ingham Claudio Battilocchio Joel M. Hawkins Steven V. Ley |
| author_sort | Richard J. Ingham |
| collection | DOAJ |
| description | Here we describe the use of a new open-source software package and a Raspberry Pi® computer for the simultaneous control of multiple flow chemistry devices and its application to a machine-assisted, multi-step flow preparation of pyrazine-2-carboxamide – a component of Rifater®, used in the treatment of tuberculosis – and its reduced derivative piperazine-2-carboxamide. |
| first_indexed | 2024-12-19T12:09:49Z |
| format | Article |
| id | doaj.art-9244366aab3341659f6c3d3567db33a2 |
| institution | Directory Open Access Journal |
| issn | 1860-5397 |
| language | English |
| last_indexed | 2024-12-19T12:09:49Z |
| publishDate | 2014-03-01 |
| publisher | Beilstein-Institut |
| record_format | Article |
| series | Beilstein Journal of Organic Chemistry |
| spelling | doaj.art-9244366aab3341659f6c3d3567db33a22022-12-21T20:22:13ZengBeilstein-InstitutBeilstein Journal of Organic Chemistry1860-53972014-03-0110164165210.3762/bjoc.10.561860-5397-10-56Integration of enabling methods for the automated flow preparation of piperazine-2-carboxamideRichard J. Ingham0Claudio Battilocchio1Joel M. Hawkins2Steven V. Ley3Innovative Technology Centre, Department of Chemistry, University of Cambridge, Lensfield Road, CB2 1EW, Cambridge, UKInnovative Technology Centre, Department of Chemistry, University of Cambridge, Lensfield Road, CB2 1EW, Cambridge, UKPfizer Worldwide Research and Development, Eastern Point Road, Groton, CT 06340, USAInnovative Technology Centre, Department of Chemistry, University of Cambridge, Lensfield Road, CB2 1EW, Cambridge, UKHere we describe the use of a new open-source software package and a Raspberry Pi® computer for the simultaneous control of multiple flow chemistry devices and its application to a machine-assisted, multi-step flow preparation of pyrazine-2-carboxamide – a component of Rifater®, used in the treatment of tuberculosis – and its reduced derivative piperazine-2-carboxamide.https://doi.org/10.3762/bjoc.10.56automationflow chemistryhydrationhydrogenationsustainable processing |
| spellingShingle | Richard J. Ingham Claudio Battilocchio Joel M. Hawkins Steven V. Ley Integration of enabling methods for the automated flow preparation of piperazine-2-carboxamide Beilstein Journal of Organic Chemistry automation flow chemistry hydration hydrogenation sustainable processing |
| title | Integration of enabling methods for the automated flow preparation of piperazine-2-carboxamide |
| title_full | Integration of enabling methods for the automated flow preparation of piperazine-2-carboxamide |
| title_fullStr | Integration of enabling methods for the automated flow preparation of piperazine-2-carboxamide |
| title_full_unstemmed | Integration of enabling methods for the automated flow preparation of piperazine-2-carboxamide |
| title_short | Integration of enabling methods for the automated flow preparation of piperazine-2-carboxamide |
| title_sort | integration of enabling methods for the automated flow preparation of piperazine 2 carboxamide |
| topic | automation flow chemistry hydration hydrogenation sustainable processing |
| url | https://doi.org/10.3762/bjoc.10.56 |
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