Botulinum Neurotoxin Therapy in the Clinical Management of Laryngeal Dystonia
Laryngeal dystonia (LD), or spasmodic dysphonia (SD), is a chronic, task-specific, focal movement disorder affecting the larynx. It interferes primarily with the essential functions of phonation and speech. LD affects patients’ ability to communicate effectively and significantly diminishes their qu...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-12-01
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| Series: | Toxins |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2072-6651/14/12/844 |
| _version_ | 1797455111350386688 |
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| author | Winnie Yeung Amanda L. Richards Daniel Novakovic |
| author_facet | Winnie Yeung Amanda L. Richards Daniel Novakovic |
| author_sort | Winnie Yeung |
| collection | DOAJ |
| description | Laryngeal dystonia (LD), or spasmodic dysphonia (SD), is a chronic, task-specific, focal movement disorder affecting the larynx. It interferes primarily with the essential functions of phonation and speech. LD affects patients’ ability to communicate effectively and significantly diminishes their quality of life. Botulinum neurotoxin was first used as a therapeutic agent in the treatment of LD four decades ago and remains the standard of care for the treatment of LD. This article provides an overview of the clinical application of botulinum neurotoxin in the management of LD, focusing on the classification for this disorder, its pathophysiology, clinical assessment and diagnosis, the role of laryngeal electromyography and a summary of therapeutic injection techniques, including a comprehensive description of various procedural approaches, recommendations for injection sites and dosage considerations. |
| first_indexed | 2024-03-09T15:46:49Z |
| format | Article |
| id | doaj.art-9245e91ab84346ceb636f02d22ce094c |
| institution | Directory Open Access Journal |
| issn | 2072-6651 |
| language | English |
| last_indexed | 2024-03-09T15:46:49Z |
| publishDate | 2022-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Toxins |
| spelling | doaj.art-9245e91ab84346ceb636f02d22ce094c2023-11-24T18:26:45ZengMDPI AGToxins2072-66512022-12-01141284410.3390/toxins14120844Botulinum Neurotoxin Therapy in the Clinical Management of Laryngeal DystoniaWinnie Yeung0Amanda L. Richards1Daniel Novakovic2Voice Research Laboratory, Faculty of Medicine and Health, University of Sydney, Camperdown, NSW 2050, AustraliaDepartment of Otolaryngology, The Royal Melbourne Hospital, Parkville, VIC 3050, AustraliaVoice Research Laboratory, Faculty of Medicine and Health, University of Sydney, Camperdown, NSW 2050, AustraliaLaryngeal dystonia (LD), or spasmodic dysphonia (SD), is a chronic, task-specific, focal movement disorder affecting the larynx. It interferes primarily with the essential functions of phonation and speech. LD affects patients’ ability to communicate effectively and significantly diminishes their quality of life. Botulinum neurotoxin was first used as a therapeutic agent in the treatment of LD four decades ago and remains the standard of care for the treatment of LD. This article provides an overview of the clinical application of botulinum neurotoxin in the management of LD, focusing on the classification for this disorder, its pathophysiology, clinical assessment and diagnosis, the role of laryngeal electromyography and a summary of therapeutic injection techniques, including a comprehensive description of various procedural approaches, recommendations for injection sites and dosage considerations.https://www.mdpi.com/2072-6651/14/12/844botulinum neurotoxinlaryngeal dystoniaspasmodic dysphoniainjectionelectromyography |
| spellingShingle | Winnie Yeung Amanda L. Richards Daniel Novakovic Botulinum Neurotoxin Therapy in the Clinical Management of Laryngeal Dystonia Toxins botulinum neurotoxin laryngeal dystonia spasmodic dysphonia injection electromyography |
| title | Botulinum Neurotoxin Therapy in the Clinical Management of Laryngeal Dystonia |
| title_full | Botulinum Neurotoxin Therapy in the Clinical Management of Laryngeal Dystonia |
| title_fullStr | Botulinum Neurotoxin Therapy in the Clinical Management of Laryngeal Dystonia |
| title_full_unstemmed | Botulinum Neurotoxin Therapy in the Clinical Management of Laryngeal Dystonia |
| title_short | Botulinum Neurotoxin Therapy in the Clinical Management of Laryngeal Dystonia |
| title_sort | botulinum neurotoxin therapy in the clinical management of laryngeal dystonia |
| topic | botulinum neurotoxin laryngeal dystonia spasmodic dysphonia injection electromyography |
| url | https://www.mdpi.com/2072-6651/14/12/844 |
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