Molecular Imaging of Bacterial Infections in vivo: The Discrimination between Infection and Inflammation
Molecular imaging by definition is the visualization of molecular and cellular processes within a given system. The modalities and reagents described here represent a diverse array spanning both pre-clinical and clinical applications. Innovations in probe design and technologies would greatly benefi...
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2014-05-01
|
| Series: | Informatics |
| Subjects: | |
| Online Access: | http://www.mdpi.com/2227-9709/1/1/72 |
| _version_ | 1818330818408349696 |
|---|---|
| author | Heather Eggleston Peter Panizzi |
| author_facet | Heather Eggleston Peter Panizzi |
| author_sort | Heather Eggleston |
| collection | DOAJ |
| description | Molecular imaging by definition is the visualization of molecular and cellular processes within a given system. The modalities and reagents described here represent a diverse array spanning both pre-clinical and clinical applications. Innovations in probe design and technologies would greatly benefit therapeutic outcomes by enhancing diagnostic accuracy and assessment of acute therapy. Opportunistic pathogens continue to pose a worldwide threat, despite advancements in treatment strategies, which highlights the continued need for improved diagnostics. In this review, we present a summary of the current clinical protocol for the imaging of a suspected infection, methods currently in development to optimize this imaging process, and finally, insight into endocarditis as a model of infectious disease in immediate need of improved diagnostic methods. |
| first_indexed | 2024-12-13T13:10:00Z |
| format | Article |
| id | doaj.art-9247008c8b504b46a9f1e58ca20316b6 |
| institution | Directory Open Access Journal |
| issn | 2227-9709 |
| language | English |
| last_indexed | 2024-12-13T13:10:00Z |
| publishDate | 2014-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Informatics |
| spelling | doaj.art-9247008c8b504b46a9f1e58ca20316b62022-12-21T23:44:43ZengMDPI AGInformatics2227-97092014-05-0111729910.3390/informatics1010072informatics1010072Molecular Imaging of Bacterial Infections in vivo: The Discrimination between Infection and InflammationHeather Eggleston0Peter Panizzi1Department of Drug Discovery and Development, Harrison School of Pharmacy, Auburn University, Auburn, AL 36849, USADepartment of Drug Discovery and Development, Harrison School of Pharmacy, Auburn University, Auburn, AL 36849, USAMolecular imaging by definition is the visualization of molecular and cellular processes within a given system. The modalities and reagents described here represent a diverse array spanning both pre-clinical and clinical applications. Innovations in probe design and technologies would greatly benefit therapeutic outcomes by enhancing diagnostic accuracy and assessment of acute therapy. Opportunistic pathogens continue to pose a worldwide threat, despite advancements in treatment strategies, which highlights the continued need for improved diagnostics. In this review, we present a summary of the current clinical protocol for the imaging of a suspected infection, methods currently in development to optimize this imaging process, and finally, insight into endocarditis as a model of infectious disease in immediate need of improved diagnostic methods.http://www.mdpi.com/2227-9709/1/1/72molecular imagingendocarditisinfectioninflammationStaphylococcus aureus |
| spellingShingle | Heather Eggleston Peter Panizzi Molecular Imaging of Bacterial Infections in vivo: The Discrimination between Infection and Inflammation Informatics molecular imaging endocarditis infection inflammation Staphylococcus aureus |
| title | Molecular Imaging of Bacterial Infections in vivo: The Discrimination between Infection and Inflammation |
| title_full | Molecular Imaging of Bacterial Infections in vivo: The Discrimination between Infection and Inflammation |
| title_fullStr | Molecular Imaging of Bacterial Infections in vivo: The Discrimination between Infection and Inflammation |
| title_full_unstemmed | Molecular Imaging of Bacterial Infections in vivo: The Discrimination between Infection and Inflammation |
| title_short | Molecular Imaging of Bacterial Infections in vivo: The Discrimination between Infection and Inflammation |
| title_sort | molecular imaging of bacterial infections in vivo the discrimination between infection and inflammation |
| topic | molecular imaging endocarditis infection inflammation Staphylococcus aureus |
| url | http://www.mdpi.com/2227-9709/1/1/72 |
| work_keys_str_mv | AT heathereggleston molecularimagingofbacterialinfectionsinvivothediscriminationbetweeninfectionandinflammation AT peterpanizzi molecularimagingofbacterialinfectionsinvivothediscriminationbetweeninfectionandinflammation |