Metabolic plasticity in blast crisis-chronic myeloid leukaemia cells under hypoxia reduces the cytotoxic potency of drugs targeting mitochondria

Metabolic plasticity in blast crisis-chronic myeloid leukaemia cells under hypoxia reduces the cytotoxic potency of drugs targeting mitochondria

Abstract Metabolic reprogramming (MR) influences progression of chronic myeloid leukaemia (CML) to blast crisis (BC), but metabolic programs may change transiently in a second dimension (metabolic plasticity, MP), driven by environments as hypoxia, affecting cytotoxic potency (CPot) of drugs targeti...

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Bibliographic Details
Main Authors: Luciana S. Salaverry, Tomás Lombardo, María C. Cabral-Lorenzo, Martin L. Gil-Folgar, Estela B. Rey-Roldán, Laura I. Kornblihtt, Guillermo A. Blanco
Format: Article
Language:English
Published: Springer 2022-07-01
Series:Discover Oncology
Subjects:
Metabolic reprogramming
Arsenic Trioxide
Dichloroacetate
Gene expression profiling
Valproic acid
Glucose uptake
Online Access:https://doi.org/10.1007/s12672-022-00524-y

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