Neurophysiological and clinical biomarkers of secondary progressive multiple sclerosis: A cross-sectional study
Timely diagnosis of secondary progressive multiple sclerosis (SPMS) represents a clinical challenge. The Frailty Index, a quantitative frailty measure, and the Neurophysiological Index, a combined measure of sensorimotor cortex inhibitory mechanism parameters, have recently emerged as promising tool...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-03-01
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| Series: | Frontiers in Neurology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fneur.2023.1138600/full |
| _version_ | 1797869634810019840 |
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| author | Matteo Tartaglia Marco Canevelli Leonardo Malimpensa Daniele Belvisi Daniele Belvisi Viola Baione Gina Ferrazzano Giorgio Leodori Giorgio Leodori Alfredo Berardelli Alfredo Berardelli Antonella Conte Antonella Conte |
| author_facet | Matteo Tartaglia Marco Canevelli Leonardo Malimpensa Daniele Belvisi Daniele Belvisi Viola Baione Gina Ferrazzano Giorgio Leodori Giorgio Leodori Alfredo Berardelli Alfredo Berardelli Antonella Conte Antonella Conte |
| author_sort | Matteo Tartaglia |
| collection | DOAJ |
| description | Timely diagnosis of secondary progressive multiple sclerosis (SPMS) represents a clinical challenge. The Frailty Index, a quantitative frailty measure, and the Neurophysiological Index, a combined measure of sensorimotor cortex inhibitory mechanism parameters, have recently emerged as promising tools to support SPMS diagnosis. The aim of this study was to explore the possible relationship between these two indices in MS. MS participants underwent a clinical evaluation, Frailty Index administration, and neurophysiological assessment. Frailty and Neurophysiological Index scores were found to be higher in SPMS and correlated with each other, thus suggesting that they may capture similar SPMS-related pathophysiological mechanisms. |
| first_indexed | 2024-04-10T00:15:43Z |
| format | Article |
| id | doaj.art-924aa9f20fce4ee28ac635e1b0a88acc |
| institution | Directory Open Access Journal |
| issn | 1664-2295 |
| language | English |
| last_indexed | 2024-04-10T00:15:43Z |
| publishDate | 2023-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neurology |
| spelling | doaj.art-924aa9f20fce4ee28ac635e1b0a88acc2023-03-16T05:13:08ZengFrontiers Media S.A.Frontiers in Neurology1664-22952023-03-011410.3389/fneur.2023.11386001138600Neurophysiological and clinical biomarkers of secondary progressive multiple sclerosis: A cross-sectional studyMatteo Tartaglia0Marco Canevelli1Leonardo Malimpensa2Daniele Belvisi3Daniele Belvisi4Viola Baione5Gina Ferrazzano6Giorgio Leodori7Giorgio Leodori8Alfredo Berardelli9Alfredo Berardelli10Antonella Conte11Antonella Conte12Department of Human Neurosciences, Sapienza University of Rome, Rome, ItalyDepartment of Human Neurosciences, Sapienza University of Rome, Rome, ItalyDepartment of Neurophysiology, IRCCS Neuromed, Pozzilli, ItalyDepartment of Human Neurosciences, Sapienza University of Rome, Rome, ItalyDepartment of Neurophysiology, IRCCS Neuromed, Pozzilli, ItalyDepartment of Human Neurosciences, Sapienza University of Rome, Rome, ItalyDepartment of Human Neurosciences, Sapienza University of Rome, Rome, ItalyDepartment of Human Neurosciences, Sapienza University of Rome, Rome, ItalyDepartment of Neurophysiology, IRCCS Neuromed, Pozzilli, ItalyDepartment of Human Neurosciences, Sapienza University of Rome, Rome, ItalyDepartment of Neurophysiology, IRCCS Neuromed, Pozzilli, ItalyDepartment of Human Neurosciences, Sapienza University of Rome, Rome, ItalyDepartment of Neurophysiology, IRCCS Neuromed, Pozzilli, ItalyTimely diagnosis of secondary progressive multiple sclerosis (SPMS) represents a clinical challenge. The Frailty Index, a quantitative frailty measure, and the Neurophysiological Index, a combined measure of sensorimotor cortex inhibitory mechanism parameters, have recently emerged as promising tools to support SPMS diagnosis. The aim of this study was to explore the possible relationship between these two indices in MS. MS participants underwent a clinical evaluation, Frailty Index administration, and neurophysiological assessment. Frailty and Neurophysiological Index scores were found to be higher in SPMS and correlated with each other, thus suggesting that they may capture similar SPMS-related pathophysiological mechanisms.https://www.frontiersin.org/articles/10.3389/fneur.2023.1138600/fullmultiple sclerosisfrailtyneurophysiologydisease progressionbiomarkerstranscranial magnetic stimulation |
| spellingShingle | Matteo Tartaglia Marco Canevelli Leonardo Malimpensa Daniele Belvisi Daniele Belvisi Viola Baione Gina Ferrazzano Giorgio Leodori Giorgio Leodori Alfredo Berardelli Alfredo Berardelli Antonella Conte Antonella Conte Neurophysiological and clinical biomarkers of secondary progressive multiple sclerosis: A cross-sectional study Frontiers in Neurology multiple sclerosis frailty neurophysiology disease progression biomarkers transcranial magnetic stimulation |
| title | Neurophysiological and clinical biomarkers of secondary progressive multiple sclerosis: A cross-sectional study |
| title_full | Neurophysiological and clinical biomarkers of secondary progressive multiple sclerosis: A cross-sectional study |
| title_fullStr | Neurophysiological and clinical biomarkers of secondary progressive multiple sclerosis: A cross-sectional study |
| title_full_unstemmed | Neurophysiological and clinical biomarkers of secondary progressive multiple sclerosis: A cross-sectional study |
| title_short | Neurophysiological and clinical biomarkers of secondary progressive multiple sclerosis: A cross-sectional study |
| title_sort | neurophysiological and clinical biomarkers of secondary progressive multiple sclerosis a cross sectional study |
| topic | multiple sclerosis frailty neurophysiology disease progression biomarkers transcranial magnetic stimulation |
| url | https://www.frontiersin.org/articles/10.3389/fneur.2023.1138600/full |
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