Peripheral blood DNA methylation and neuroanatomical responses to HDACi treatment that rescues neurological deficits in a Kabuki syndrome mouse model
Abstract Background Recent findings from studies of mouse models of Mendelian disorders of epigenetic machinery strongly support the potential for postnatal therapies to improve neurobehavioral and cognitive deficits. As several of these therapies move into human clinical trials, the search for biom...
Main Authors: | Sarah Jessica Goodman, Teresa Romeo Luperchio, Jacob Ellegood, Eric Chater-Diehl, Jason P. Lerch, Hans Tomas Bjornsson, Rosanna Weksberg |
---|---|
Format: | Article |
Language: | English |
Published: |
BMC
2023-10-01
|
Series: | Clinical Epigenetics |
Online Access: | https://doi.org/10.1186/s13148-023-01582-x |
Similar Items
-
Haploinsufficiency of KMT2D is sufficient to cause Kabuki syndrome and is compatible with life
by: Teresa Romeo Luperchio, et al.
Published: (2020-02-01) -
P837: DNA methylation profiling in Kabuki syndrome: Steps towards improved classification of variants of uncertain significance
by: Sanaa Choufani, et al.
Published: (2024-01-01) -
Neurobehavioral phenotype of Kabuki syndrome: Anxiety is a common feature
by: Allison J. Kalinousky, et al.
Published: (2022-10-01) -
Sodium Butyrate Enhances the Cytotoxic Effect of Etoposide in HDACi-Sensitive and HDACi-Resistant Transformed Cells
by: Olga O. Gnedina, et al.
Published: (2023-11-01) -
KABUKI
by: , PRAEDIVA TRIPUTRA SUSETIONO, et al.
Published: (2014)