Biometric and Structural Ocular Manifestations of Anterior Megalophthalmos
ObjectiveThe aim of this study was to examine the biometric ocular manifestations and structural ocular features of anterior megalophthalmos (AM).MethodsFifteen patients with AM (30 eyes) from the Eye & ENT Hospital of Fudan University were included. The age-matched control group consisted o...
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Frontiers Media S.A.
2022-05-01
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fmed.2022.732452/full |
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| author | Tian-Hui Chen Tian-Hui Chen Tian-Hui Chen Ze-Xu Chen Ze-Xu Chen Ze-Xu Chen Min Zhang Min Zhang Min Zhang Jia-Hui Chen Jia-Hui Chen Jia-Hui Chen Li-Na Lan Li-Na Lan Li-Na Lan Yongxiang Jiang Yongxiang Jiang Yongxiang Jiang |
| author_facet | Tian-Hui Chen Tian-Hui Chen Tian-Hui Chen Ze-Xu Chen Ze-Xu Chen Ze-Xu Chen Min Zhang Min Zhang Min Zhang Jia-Hui Chen Jia-Hui Chen Jia-Hui Chen Li-Na Lan Li-Na Lan Li-Na Lan Yongxiang Jiang Yongxiang Jiang Yongxiang Jiang |
| author_sort | Tian-Hui Chen |
| collection | DOAJ |
| description | ObjectiveThe aim of this study was to examine the biometric ocular manifestations and structural ocular features of anterior megalophthalmos (AM).MethodsFifteen patients with AM (30 eyes) from the Eye & ENT Hospital of Fudan University were included. The age-matched control group consisted of 30 participants (30 eyes) who underwent Pentacam HR and IOLMaster 700 measurements for one normal eye. Data on demographics, biometric manifestations, and genotypes were carefully compared.ResultsA total of 15 patients with AM and 30 control patients were enrolled. There were no differences in age (37.27 ± 19.1 vs. 31.43 ± 19.69 years, P = 0.249) between these two groups. AM eyes were characterized by premature cataracts (11/30, 36.67%) and zonular weakness with lens subluxation (22/30, 73.33%) compared with the control group. Notably, 20 of the 30 AM eyes (66.67%) had significant posterior iris bowing, and 16 of the 30 AM eyes (53.33%) showed an enlarged ciliary ring on ultrasound biomicroscopy (UBM). Mean corneal curvature was lower in the AM eyes (42.01 ± 2.06 D vs. 43.14 ± 1.38 D, P = 0.023). There was no significant difference in corneal pachymetry and central endothelial cell count between the AM and control groups. Significant differences were found in terms of the anterior chamber and white-to-white (WTW) among the Pentacam HR and IOLMaster 700 in patients with AM (P < 0.05). The difference was 0.53 ± 0.48 mm and 0.36 ± 0.14 mm, respectively (P < 0.001).ConclusionThe results of this cohort study conclude the biometric and structural ocular manifestations in Chinese cohorts. Posterior iris bowing (66.67%) and lens subluxation (73.33%) are the most characteristic findings in patients with AM with anatomical abnormalities of megalocornea and a deep anterior chamber, although corneal biometric manifestations of AM included flatter cornea and lower total corneal astigmatism. The knowledge of ocular manifestations of AM is important for diagnosis and preparation for the operation in advance to avoid intraoperative and postoperative complications. Significant differences were found in the anterior chamber and WTW values between the Pentacam HR and IOLMaster 700. Thus, we suggest that various examinations should be carefully considered before determining an AM diagnosis. |
| first_indexed | 2024-12-12T14:25:38Z |
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| last_indexed | 2024-12-12T14:25:38Z |
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| spelling | doaj.art-924bdd9f577e44149f92a571961369b02022-12-22T00:21:41ZengFrontiers Media S.A.Frontiers in Medicine2296-858X2022-05-01910.3389/fmed.2022.732452732452Biometric and Structural Ocular Manifestations of Anterior MegalophthalmosTian-Hui Chen0Tian-Hui Chen1Tian-Hui Chen2Ze-Xu Chen3Ze-Xu Chen4Ze-Xu Chen5Min Zhang6Min Zhang7Min Zhang8Jia-Hui Chen9Jia-Hui Chen10Jia-Hui Chen11Li-Na Lan12Li-Na Lan13Li-Na Lan14Yongxiang Jiang15Yongxiang Jiang16Yongxiang Jiang17Department of Ophthalmology and Vision Science, Eye & ENT Hospital of Fudan University, Shanghai, ChinaKey Laboratory of Myopia of State Health Ministry, Shanghai Key Laboratory of Visual Impairment and Restoration, Shanghai, ChinaState Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, ChinaDepartment of Ophthalmology and Vision Science, Eye & ENT Hospital of Fudan University, Shanghai, ChinaKey Laboratory of Myopia of State Health Ministry, Shanghai Key Laboratory of Visual Impairment and Restoration, Shanghai, ChinaState Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, ChinaDepartment of Ophthalmology and Vision Science, Eye & ENT Hospital of Fudan University, Shanghai, ChinaKey Laboratory of Myopia of State Health Ministry, Shanghai Key Laboratory of Visual Impairment and Restoration, Shanghai, ChinaState Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, ChinaDepartment of Ophthalmology and Vision Science, Eye & ENT Hospital of Fudan University, Shanghai, ChinaKey Laboratory of Myopia of State Health Ministry, Shanghai Key Laboratory of Visual Impairment and Restoration, Shanghai, ChinaState Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, ChinaDepartment of Ophthalmology and Vision Science, Eye & ENT Hospital of Fudan University, Shanghai, ChinaKey Laboratory of Myopia of State Health Ministry, Shanghai Key Laboratory of Visual Impairment and Restoration, Shanghai, ChinaState Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, ChinaDepartment of Ophthalmology and Vision Science, Eye & ENT Hospital of Fudan University, Shanghai, ChinaKey Laboratory of Myopia of State Health Ministry, Shanghai Key Laboratory of Visual Impairment and Restoration, Shanghai, ChinaState Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, ChinaObjectiveThe aim of this study was to examine the biometric ocular manifestations and structural ocular features of anterior megalophthalmos (AM).MethodsFifteen patients with AM (30 eyes) from the Eye & ENT Hospital of Fudan University were included. The age-matched control group consisted of 30 participants (30 eyes) who underwent Pentacam HR and IOLMaster 700 measurements for one normal eye. Data on demographics, biometric manifestations, and genotypes were carefully compared.ResultsA total of 15 patients with AM and 30 control patients were enrolled. There were no differences in age (37.27 ± 19.1 vs. 31.43 ± 19.69 years, P = 0.249) between these two groups. AM eyes were characterized by premature cataracts (11/30, 36.67%) and zonular weakness with lens subluxation (22/30, 73.33%) compared with the control group. Notably, 20 of the 30 AM eyes (66.67%) had significant posterior iris bowing, and 16 of the 30 AM eyes (53.33%) showed an enlarged ciliary ring on ultrasound biomicroscopy (UBM). Mean corneal curvature was lower in the AM eyes (42.01 ± 2.06 D vs. 43.14 ± 1.38 D, P = 0.023). There was no significant difference in corneal pachymetry and central endothelial cell count between the AM and control groups. Significant differences were found in terms of the anterior chamber and white-to-white (WTW) among the Pentacam HR and IOLMaster 700 in patients with AM (P < 0.05). The difference was 0.53 ± 0.48 mm and 0.36 ± 0.14 mm, respectively (P < 0.001).ConclusionThe results of this cohort study conclude the biometric and structural ocular manifestations in Chinese cohorts. Posterior iris bowing (66.67%) and lens subluxation (73.33%) are the most characteristic findings in patients with AM with anatomical abnormalities of megalocornea and a deep anterior chamber, although corneal biometric manifestations of AM included flatter cornea and lower total corneal astigmatism. The knowledge of ocular manifestations of AM is important for diagnosis and preparation for the operation in advance to avoid intraoperative and postoperative complications. Significant differences were found in the anterior chamber and WTW values between the Pentacam HR and IOLMaster 700. Thus, we suggest that various examinations should be carefully considered before determining an AM diagnosis.https://www.frontiersin.org/articles/10.3389/fmed.2022.732452/fullanterior megalophthalmosocular manifestationslens subluxationcataractmegalocornea |
| spellingShingle | Tian-Hui Chen Tian-Hui Chen Tian-Hui Chen Ze-Xu Chen Ze-Xu Chen Ze-Xu Chen Min Zhang Min Zhang Min Zhang Jia-Hui Chen Jia-Hui Chen Jia-Hui Chen Li-Na Lan Li-Na Lan Li-Na Lan Yongxiang Jiang Yongxiang Jiang Yongxiang Jiang Biometric and Structural Ocular Manifestations of Anterior Megalophthalmos Frontiers in Medicine anterior megalophthalmos ocular manifestations lens subluxation cataract megalocornea |
| title | Biometric and Structural Ocular Manifestations of Anterior Megalophthalmos |
| title_full | Biometric and Structural Ocular Manifestations of Anterior Megalophthalmos |
| title_fullStr | Biometric and Structural Ocular Manifestations of Anterior Megalophthalmos |
| title_full_unstemmed | Biometric and Structural Ocular Manifestations of Anterior Megalophthalmos |
| title_short | Biometric and Structural Ocular Manifestations of Anterior Megalophthalmos |
| title_sort | biometric and structural ocular manifestations of anterior megalophthalmos |
| topic | anterior megalophthalmos ocular manifestations lens subluxation cataract megalocornea |
| url | https://www.frontiersin.org/articles/10.3389/fmed.2022.732452/full |
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