Prolonged COVID-19 Infection in a Patient with Complete Remission from Follicular Lymphoma with Hyperosmolar Hyperglycemic Syndrome
An 81-year-old woman undergoing B-cell depletion therapy developed COVID-19 and a hyperglycemic hyperosmotic state. She had a history of multiple vaccinations against coronaviruses but had persistent antigen positivity. Strategies to prevent the development of COVID-19 in immunosuppressed patients h...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-11-01
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| Series: | Geriatrics |
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| Online Access: | https://www.mdpi.com/2308-3417/8/6/110 |
| _version_ | 1797380922842021888 |
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| author | Takuya Omura Akira Katsumi Shuji Kawashima Masahiro Naya Haruhiko Tokuda |
| author_facet | Takuya Omura Akira Katsumi Shuji Kawashima Masahiro Naya Haruhiko Tokuda |
| author_sort | Takuya Omura |
| collection | DOAJ |
| description | An 81-year-old woman undergoing B-cell depletion therapy developed COVID-19 and a hyperglycemic hyperosmotic state. She had a history of multiple vaccinations against coronaviruses but had persistent antigen positivity. Strategies to prevent the development of COVID-19 in immunosuppressed patients have not been established. Moreover, there is no standard treatment for prolonged antigen positivity. In this case, we were able to follow IgG antibodies during the course of treatment. The absence of N-IgG antibody titer elevation despite an effective immune response triggered by the vaccine is of great interest. The impaired humoral response observed in patients with lymphoma after anti-CD20 treatment implies the need for a justified different vaccination strategy for these patients. Furthermore, negative N-IgG titers in the immunosuppressed state may serve as an indicator of resistance to therapy. |
| first_indexed | 2024-03-08T20:43:57Z |
| format | Article |
| id | doaj.art-924c38f91dd147e788f3005cf4769093 |
| institution | Directory Open Access Journal |
| issn | 2308-3417 |
| language | English |
| last_indexed | 2024-03-08T20:43:57Z |
| publishDate | 2023-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Geriatrics |
| spelling | doaj.art-924c38f91dd147e788f3005cf47690932023-12-22T14:11:44ZengMDPI AGGeriatrics2308-34172023-11-018611010.3390/geriatrics8060110Prolonged COVID-19 Infection in a Patient with Complete Remission from Follicular Lymphoma with Hyperosmolar Hyperglycemic SyndromeTakuya Omura0Akira Katsumi1Shuji Kawashima2Masahiro Naya3Haruhiko Tokuda4Department of Endocrinology and Metabolism, National Center for Geriatrics and Gerontology, 7-430 Morioka-cho, Obu 474-8511, Aichi, JapanDepartment of Hematology, National Center for Geriatrics and Gerontology, 7-430 Morioka-cho, Obu 474-8511, Aichi, JapanDepartment of Endocrinology and Metabolism, National Center for Geriatrics and Gerontology, 7-430 Morioka-cho, Obu 474-8511, Aichi, JapanDepartment of Clinical Laboratory, National Center for Geriatrics and Gerontology, 7-430 Morioka-cho, Obu 474-8511, Aichi, JapanDepartment of Endocrinology and Metabolism, National Center for Geriatrics and Gerontology, 7-430 Morioka-cho, Obu 474-8511, Aichi, JapanAn 81-year-old woman undergoing B-cell depletion therapy developed COVID-19 and a hyperglycemic hyperosmotic state. She had a history of multiple vaccinations against coronaviruses but had persistent antigen positivity. Strategies to prevent the development of COVID-19 in immunosuppressed patients have not been established. Moreover, there is no standard treatment for prolonged antigen positivity. In this case, we were able to follow IgG antibodies during the course of treatment. The absence of N-IgG antibody titer elevation despite an effective immune response triggered by the vaccine is of great interest. The impaired humoral response observed in patients with lymphoma after anti-CD20 treatment implies the need for a justified different vaccination strategy for these patients. Furthermore, negative N-IgG titers in the immunosuppressed state may serve as an indicator of resistance to therapy.https://www.mdpi.com/2308-3417/8/6/110follicular lymphomahyperosmolar hyperglycemia syndromeprolonged COVID-19tixagevimab/cilgavimab |
| spellingShingle | Takuya Omura Akira Katsumi Shuji Kawashima Masahiro Naya Haruhiko Tokuda Prolonged COVID-19 Infection in a Patient with Complete Remission from Follicular Lymphoma with Hyperosmolar Hyperglycemic Syndrome Geriatrics follicular lymphoma hyperosmolar hyperglycemia syndrome prolonged COVID-19 tixagevimab/cilgavimab |
| title | Prolonged COVID-19 Infection in a Patient with Complete Remission from Follicular Lymphoma with Hyperosmolar Hyperglycemic Syndrome |
| title_full | Prolonged COVID-19 Infection in a Patient with Complete Remission from Follicular Lymphoma with Hyperosmolar Hyperglycemic Syndrome |
| title_fullStr | Prolonged COVID-19 Infection in a Patient with Complete Remission from Follicular Lymphoma with Hyperosmolar Hyperglycemic Syndrome |
| title_full_unstemmed | Prolonged COVID-19 Infection in a Patient with Complete Remission from Follicular Lymphoma with Hyperosmolar Hyperglycemic Syndrome |
| title_short | Prolonged COVID-19 Infection in a Patient with Complete Remission from Follicular Lymphoma with Hyperosmolar Hyperglycemic Syndrome |
| title_sort | prolonged covid 19 infection in a patient with complete remission from follicular lymphoma with hyperosmolar hyperglycemic syndrome |
| topic | follicular lymphoma hyperosmolar hyperglycemia syndrome prolonged COVID-19 tixagevimab/cilgavimab |
| url | https://www.mdpi.com/2308-3417/8/6/110 |
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