Cerebrospinal fluid biomarkers in Parkinson’s disease with freezing of gait: an exploratory analysis
Abstract We explore the association between three Alzheimer’s disease-related and ten inflammation-related CSF markers and freezing of gait (FOG) in patients with Parkinson’s disease (PD). The study population includes PD patients with FOG (PD-FOG, N = 12), without FOG (PD-NoFOG, N = 19), and health...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2021-11-01
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| Series: | npj Parkinson's Disease |
| Online Access: | https://doi.org/10.1038/s41531-021-00247-x |
| _version_ | 1797642655466782720 |
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| author | J. M. Hatcher-Martin J. L. McKay A. F. Pybus B. Sommerfeld J. C. Howell F. C. Goldstein L. Wood W. T. Hu S. A. Factor |
| author_facet | J. M. Hatcher-Martin J. L. McKay A. F. Pybus B. Sommerfeld J. C. Howell F. C. Goldstein L. Wood W. T. Hu S. A. Factor |
| author_sort | J. M. Hatcher-Martin |
| collection | DOAJ |
| description | Abstract We explore the association between three Alzheimer’s disease-related and ten inflammation-related CSF markers and freezing of gait (FOG) in patients with Parkinson’s disease (PD). The study population includes PD patients with FOG (PD-FOG, N = 12), without FOG (PD-NoFOG, N = 19), and healthy controls (HC, N = 12). Age and PD duration are not significantly different between groups. After adjusting for covariates and multiple comparisons, the anti-inflammatory marker, fractalkine, is significantly decreased in the PD groups compared to HC (P = 0.002), and further decreased in PD-FOG compared to PD-NoFOG (P = 0.007). The Alzheimer’s disease-related protein, Aβ42, is increased in PD-FOG compared to PD-NoFOG and HC (P = 0.001). Group differences obtained in individual biomarker analyses are confirmed with multivariate discriminant partial least squares regression (P < 0.001). High levels of Aβ42 in PD-FOG patients supports an increase over time from early to advanced state. Low levels of fractalkine might suggest anti-inflammatory effect. These findings warrant replication. |
| first_indexed | 2024-03-11T14:03:26Z |
| format | Article |
| id | doaj.art-924d91281f934f699f164f0dae6b1608 |
| institution | Directory Open Access Journal |
| issn | 2373-8057 |
| language | English |
| last_indexed | 2024-03-11T14:03:26Z |
| publishDate | 2021-11-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | npj Parkinson's Disease |
| spelling | doaj.art-924d91281f934f699f164f0dae6b16082023-11-02T03:32:10ZengNature Portfolionpj Parkinson's Disease2373-80572021-11-01711710.1038/s41531-021-00247-xCerebrospinal fluid biomarkers in Parkinson’s disease with freezing of gait: an exploratory analysisJ. M. Hatcher-Martin0J. L. McKay1A. F. Pybus2B. Sommerfeld3J. C. Howell4F. C. Goldstein5L. Wood6W. T. Hu7S. A. Factor8Jean & Paul Amos PD & Movement Disorders Program, Department of Neurology, Emory UniversityJean & Paul Amos PD & Movement Disorders Program, Department of Neurology, Emory UniversityDepartment of Mechanical Engineering, Georgia TechJean & Paul Amos PD & Movement Disorders Program, Department of Neurology, Emory UniversityNeurology Consultants of DallasNeuropsychology Program, Department of Neurology, Emory UniversityDepartment of Mechanical Engineering, Georgia TechAlzheimer’s Disease Research Center, Emory University and Cognitive Neurology Division, Rutgers-Robert Wood Johnson Medical School and Institute for Health, Health Care Policy, and Aging ResearchJean & Paul Amos PD & Movement Disorders Program, Department of Neurology, Emory UniversityAbstract We explore the association between three Alzheimer’s disease-related and ten inflammation-related CSF markers and freezing of gait (FOG) in patients with Parkinson’s disease (PD). The study population includes PD patients with FOG (PD-FOG, N = 12), without FOG (PD-NoFOG, N = 19), and healthy controls (HC, N = 12). Age and PD duration are not significantly different between groups. After adjusting for covariates and multiple comparisons, the anti-inflammatory marker, fractalkine, is significantly decreased in the PD groups compared to HC (P = 0.002), and further decreased in PD-FOG compared to PD-NoFOG (P = 0.007). The Alzheimer’s disease-related protein, Aβ42, is increased in PD-FOG compared to PD-NoFOG and HC (P = 0.001). Group differences obtained in individual biomarker analyses are confirmed with multivariate discriminant partial least squares regression (P < 0.001). High levels of Aβ42 in PD-FOG patients supports an increase over time from early to advanced state. Low levels of fractalkine might suggest anti-inflammatory effect. These findings warrant replication.https://doi.org/10.1038/s41531-021-00247-x |
| spellingShingle | J. M. Hatcher-Martin J. L. McKay A. F. Pybus B. Sommerfeld J. C. Howell F. C. Goldstein L. Wood W. T. Hu S. A. Factor Cerebrospinal fluid biomarkers in Parkinson’s disease with freezing of gait: an exploratory analysis npj Parkinson's Disease |
| title | Cerebrospinal fluid biomarkers in Parkinson’s disease with freezing of gait: an exploratory analysis |
| title_full | Cerebrospinal fluid biomarkers in Parkinson’s disease with freezing of gait: an exploratory analysis |
| title_fullStr | Cerebrospinal fluid biomarkers in Parkinson’s disease with freezing of gait: an exploratory analysis |
| title_full_unstemmed | Cerebrospinal fluid biomarkers in Parkinson’s disease with freezing of gait: an exploratory analysis |
| title_short | Cerebrospinal fluid biomarkers in Parkinson’s disease with freezing of gait: an exploratory analysis |
| title_sort | cerebrospinal fluid biomarkers in parkinson s disease with freezing of gait an exploratory analysis |
| url | https://doi.org/10.1038/s41531-021-00247-x |
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