Prognostic and Clinicopathological Significance of MiR-155 in Breast Cancer: A Systematic Review
There is an unmet need for novel non-invasive prognostic molecular tumour markers for breast cancer (BC). Accumulating evidence shows that miR-155 plays a pivotal role in tumorigenesis. Generally, miR-155 is considered an oncogenic miRNA promoting tumour growth, angiogenesis and aggressiveness of BC...
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-08-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/21/16/5834 |
| _version_ | 1797558160373841920 |
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| author | Anna Maria Grimaldi Silvia Nuzzo Gerolama Condorelli Marco Salvatore Mariarosaria Incoronato |
| author_facet | Anna Maria Grimaldi Silvia Nuzzo Gerolama Condorelli Marco Salvatore Mariarosaria Incoronato |
| author_sort | Anna Maria Grimaldi |
| collection | DOAJ |
| description | There is an unmet need for novel non-invasive prognostic molecular tumour markers for breast cancer (BC). Accumulating evidence shows that miR-155 plays a pivotal role in tumorigenesis. Generally, miR-155 is considered an oncogenic miRNA promoting tumour growth, angiogenesis and aggressiveness of BC. Therefore, many researchers have focused on its <i>use</i> as a <i>prognostic</i> biomarker and therapeutic target. However, its prognostic value for BC patients remains controversial. To address this issue, the present systematic review aims to summarize the available evidence and give a picture of a prognostic significance of miR-155 in BC pathology. All eligible studies were searched on PubMed and EMBASE databases through various search strategies. Starting from 289 potential eligible records, data were examined from 28 studies, comparing tissue and circulating miR-155 expression levels with clinicopathological features and survival rates in BC patients. We discuss the pitfalls and challenges that need to be assessed to understand the power of miR-155 to respond to real clinical needs, highlighting the consistency, robustness or lack of results obtained to sate in translating this molecule to clinical practice. Our paper suggests that the prognostic role of miR-155 in the management of BC needs to be further verified. |
| first_indexed | 2024-03-10T17:27:35Z |
| format | Article |
| id | doaj.art-924deeb6d6c3436886f55c6265a0f924 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T17:27:35Z |
| publishDate | 2020-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-924deeb6d6c3436886f55c6265a0f9242023-11-20T10:08:05ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672020-08-012116583410.3390/ijms21165834Prognostic and Clinicopathological Significance of MiR-155 in Breast Cancer: A Systematic ReviewAnna Maria Grimaldi0Silvia Nuzzo1Gerolama Condorelli2Marco Salvatore3Mariarosaria Incoronato4IRCCS SDN, Via Emanuele Gianturco 113, 80143 Naples, ItalyIRCCS SDN, Via Emanuele Gianturco 113, 80143 Naples, ItalyDepartment of Molecular Medicine and Medical Biotechnology, “Federico II” University of Naples, Via Pansini 5, 80131 Naples, ItalyIRCCS SDN, Via Emanuele Gianturco 113, 80143 Naples, ItalyIRCCS SDN, Via Emanuele Gianturco 113, 80143 Naples, ItalyThere is an unmet need for novel non-invasive prognostic molecular tumour markers for breast cancer (BC). Accumulating evidence shows that miR-155 plays a pivotal role in tumorigenesis. Generally, miR-155 is considered an oncogenic miRNA promoting tumour growth, angiogenesis and aggressiveness of BC. Therefore, many researchers have focused on its <i>use</i> as a <i>prognostic</i> biomarker and therapeutic target. However, its prognostic value for BC patients remains controversial. To address this issue, the present systematic review aims to summarize the available evidence and give a picture of a prognostic significance of miR-155 in BC pathology. All eligible studies were searched on PubMed and EMBASE databases through various search strategies. Starting from 289 potential eligible records, data were examined from 28 studies, comparing tissue and circulating miR-155 expression levels with clinicopathological features and survival rates in BC patients. We discuss the pitfalls and challenges that need to be assessed to understand the power of miR-155 to respond to real clinical needs, highlighting the consistency, robustness or lack of results obtained to sate in translating this molecule to clinical practice. Our paper suggests that the prognostic role of miR-155 in the management of BC needs to be further verified.https://www.mdpi.com/1422-0067/21/16/5834microRNAmiR-155breast cancerprognosisdiagnosistissue |
| spellingShingle | Anna Maria Grimaldi Silvia Nuzzo Gerolama Condorelli Marco Salvatore Mariarosaria Incoronato Prognostic and Clinicopathological Significance of MiR-155 in Breast Cancer: A Systematic Review International Journal of Molecular Sciences microRNA miR-155 breast cancer prognosis diagnosis tissue |
| title | Prognostic and Clinicopathological Significance of MiR-155 in Breast Cancer: A Systematic Review |
| title_full | Prognostic and Clinicopathological Significance of MiR-155 in Breast Cancer: A Systematic Review |
| title_fullStr | Prognostic and Clinicopathological Significance of MiR-155 in Breast Cancer: A Systematic Review |
| title_full_unstemmed | Prognostic and Clinicopathological Significance of MiR-155 in Breast Cancer: A Systematic Review |
| title_short | Prognostic and Clinicopathological Significance of MiR-155 in Breast Cancer: A Systematic Review |
| title_sort | prognostic and clinicopathological significance of mir 155 in breast cancer a systematic review |
| topic | microRNA miR-155 breast cancer prognosis diagnosis tissue |
| url | https://www.mdpi.com/1422-0067/21/16/5834 |
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