Myeloid-derived suppressor cells endow stem-like qualities to multiple myeloma cells by inducing piRNA-823 expression and DNMT3B activation

Myeloid-derived suppressor cells endow stem-like qualities to multiple myeloma cells by inducing piRNA-823 expression and DNMT3B activation

Abstract Background Myeloid-derived suppressor cells (MDSCs) and cancer stem cells (CSCs) are two important cellular components in the tumor microenvironment, which may modify the cancer phenotype and affect patient survival. However, the crosstalk between MDSCs and multiple myeloma stem cells (MMSC...

Full description

Bibliographic Details
Main Authors: Lisha Ai, Shidai Mu, Chunyan Sun, Fengjuan Fan, Han Yan, You Qin, Guohui Cui, Yadan Wang, Tao Guo, Heng Mei, Huafang Wang, Yu Hu
Format: Article
Language:English
Published: BMC 2019-04-01
Series:Molecular Cancer
Subjects:
Multiple myeloma
Myeloid-derived suppressor cells
Cancer stem cells
piRNA
DNA methylation
Online Access:http://link.springer.com/article/10.1186/s12943-019-1011-5

Similar Items

Similar Items