H7N9 Avian Influenza A Virus and the Perpetual Challenge of Potential Human Pandemicity
ABSTRACT The ongoing H7N9 influenza epizootic in China once again presents us questions about the origin of pandemics and how to recognize them in early stages of development. Over the past ~135 years, H7 influenza viruses have neither caused pandemics nor been recognized as having undergone human a...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
American Society for Microbiology
2013-08-01
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| Series: | mBio |
| Online Access: | https://journals.asm.org/doi/10.1128/mBio.00445-13 |
| _version_ | 1819041479670104064 |
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| author | David M. Morens Jeffery K. Taubenberger Anthony S. Fauci |
| author_facet | David M. Morens Jeffery K. Taubenberger Anthony S. Fauci |
| author_sort | David M. Morens |
| collection | DOAJ |
| description | ABSTRACT The ongoing H7N9 influenza epizootic in China once again presents us questions about the origin of pandemics and how to recognize them in early stages of development. Over the past ~135 years, H7 influenza viruses have neither caused pandemics nor been recognized as having undergone human adaptation. Yet several unusual properties of these viruses, including their poultry epizootic potential, mammalian adaptation, and atypical clinical syndromes in rarely infected humans, suggest that they may be different from other avian influenza viruses, thus questioning any assurance that the likelihood of human adaptation is low. At the same time, the H7N9 epizootic provides an opportunity to learn more about the mammalian/human adaptational capabilities of avian influenza viruses and challenges us to integrate virologic and public health research and surveillance at the animal-human interface. |
| first_indexed | 2024-12-21T09:25:39Z |
| format | Article |
| id | doaj.art-924e1b3935084b8dafe6bb2abada6022 |
| institution | Directory Open Access Journal |
| issn | 2150-7511 |
| language | English |
| last_indexed | 2024-12-21T09:25:39Z |
| publishDate | 2013-08-01 |
| publisher | American Society for Microbiology |
| record_format | Article |
| series | mBio |
| spelling | doaj.art-924e1b3935084b8dafe6bb2abada60222022-12-21T19:08:54ZengAmerican Society for MicrobiologymBio2150-75112013-08-014410.1128/mBio.00445-13H7N9 Avian Influenza A Virus and the Perpetual Challenge of Potential Human PandemicityDavid M. Morens0Jeffery K. Taubenberger1Anthony S. Fauci2Office of the Director, Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USAViral Pathogenesis and Evolution Section, Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USAOffice of the Director, Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USAABSTRACT The ongoing H7N9 influenza epizootic in China once again presents us questions about the origin of pandemics and how to recognize them in early stages of development. Over the past ~135 years, H7 influenza viruses have neither caused pandemics nor been recognized as having undergone human adaptation. Yet several unusual properties of these viruses, including their poultry epizootic potential, mammalian adaptation, and atypical clinical syndromes in rarely infected humans, suggest that they may be different from other avian influenza viruses, thus questioning any assurance that the likelihood of human adaptation is low. At the same time, the H7N9 epizootic provides an opportunity to learn more about the mammalian/human adaptational capabilities of avian influenza viruses and challenges us to integrate virologic and public health research and surveillance at the animal-human interface.https://journals.asm.org/doi/10.1128/mBio.00445-13 |
| spellingShingle | David M. Morens Jeffery K. Taubenberger Anthony S. Fauci H7N9 Avian Influenza A Virus and the Perpetual Challenge of Potential Human Pandemicity mBio |
| title | H7N9 Avian Influenza A Virus and the Perpetual Challenge of Potential Human Pandemicity |
| title_full | H7N9 Avian Influenza A Virus and the Perpetual Challenge of Potential Human Pandemicity |
| title_fullStr | H7N9 Avian Influenza A Virus and the Perpetual Challenge of Potential Human Pandemicity |
| title_full_unstemmed | H7N9 Avian Influenza A Virus and the Perpetual Challenge of Potential Human Pandemicity |
| title_short | H7N9 Avian Influenza A Virus and the Perpetual Challenge of Potential Human Pandemicity |
| title_sort | h7n9 avian influenza a virus and the perpetual challenge of potential human pandemicity |
| url | https://journals.asm.org/doi/10.1128/mBio.00445-13 |
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