Optical coherence tomography angiography helps distinguish multiple sclerosis from AQP4‐IgG‐seropositive neuromyelitis optica spectrum disorder
Abstract Introduction The aim was to characterize the optical coherence tomography (OCT) angiography measures in patients with multiple sclerosis (MS) and neuromyelitis optica spectrum disorder (NMOSD) and to evaluate their disease discrimination capacity. Methods Patients with MS (n = 83) and AQP4‐...
| Main Authors: | , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2021-05-01
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| Series: | Brain and Behavior |
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| Online Access: | https://doi.org/10.1002/brb3.2125 |
| _version_ | 1830350116349804544 |
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| author | Chunxin Liu Hui Xiao Xiayin Zhang Yipeng Zhao Rui Li Xiaonan Zhong Yuge Wang Yaqing Shu Yanyu Chang Jingqi Wang Caixia Li Haotian Lin Wei Qiu |
| author_facet | Chunxin Liu Hui Xiao Xiayin Zhang Yipeng Zhao Rui Li Xiaonan Zhong Yuge Wang Yaqing Shu Yanyu Chang Jingqi Wang Caixia Li Haotian Lin Wei Qiu |
| author_sort | Chunxin Liu |
| collection | DOAJ |
| description | Abstract Introduction The aim was to characterize the optical coherence tomography (OCT) angiography measures in patients with multiple sclerosis (MS) and neuromyelitis optica spectrum disorder (NMOSD) and to evaluate their disease discrimination capacity. Methods Patients with MS (n = 83) and AQP4‐IgG‐seropositive NMOSD (n = 91) with or without a history of optic neuritis, together with healthy controls (n = 34), were imaged. The main outcome measures were peripapillary retinal nerve fiber layer (pRNFL) thickness, macular ganglion cell‐inner plexiform layer (GC‐IPL) thickness, macular vessel density (VD), and perfusion density (PD) in the superficial capillary plexus. Diagnostic accuracy was assessed using the area under the receiver operating characteristics curve. Results Compared with patients with MS, those with NMOSD had a significantly smaller average thickness of the pRNFL and GC‐IPL (80.0 [59.0; 95.8] μm versus 92.0 [80.2; 101] μm, p < .001; 68.0 [56.0; 81.0] μm, versus 74.5 [64.2; 81.0] μm, p < .001) and significantly smaller whole VD and PD areas (15.6 [12.6; 17.0] mm−1 versus 16.7 [14.8; 17.7] mm−1, p < .001; 0.38 [0.31; 0.42] mm−1 versus 0.40 [0.37; 0.43] mm−1, p < .01). The combination of structural parameters (average thickness of the pRNFL and GC‐IPL) with microvascular parameters (temporal‐inner quadrant of VD, temporal‐inner, nasal‐inferior, and nasal‐outer quadrant of PD) was revealed to have a good diagnostic capability for discriminating between NMOSD and MS. Conclusions OCT angiography reveals different structural and microvascular retinal changes in MS and AQP4‐IgG‐seropositive NMOSD. These combined structural and microvascular parameters might be promising biomarkers for disease diagnosis. |
| first_indexed | 2024-12-20T00:15:42Z |
| format | Article |
| id | doaj.art-924ec1af10214ea1a0664cece14c5548 |
| institution | Directory Open Access Journal |
| issn | 2162-3279 |
| language | English |
| last_indexed | 2024-12-20T00:15:42Z |
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| series | Brain and Behavior |
| spelling | doaj.art-924ec1af10214ea1a0664cece14c55482022-12-21T20:00:23ZengWileyBrain and Behavior2162-32792021-05-01115n/an/a10.1002/brb3.2125Optical coherence tomography angiography helps distinguish multiple sclerosis from AQP4‐IgG‐seropositive neuromyelitis optica spectrum disorderChunxin Liu0Hui Xiao1Xiayin Zhang2Yipeng Zhao3Rui Li4Xiaonan Zhong5Yuge Wang6Yaqing Shu7Yanyu Chang8Jingqi Wang9Caixia Li10Haotian Lin11Wei Qiu12Department of Neurology Third Affiliated HospitalSun Yat‐sen University Guangzhou ChinaZhongshan Ophthalmic CenterSun Yat‐sen University Guangzhou ChinaZhongshan Ophthalmic CenterSun Yat‐sen University Guangzhou ChinaDepartment of Neurology Third Affiliated HospitalSun Yat‐sen University Guangzhou ChinaDepartment of Neurology Third Affiliated HospitalSun Yat‐sen University Guangzhou ChinaDepartment of Neurology Third Affiliated HospitalSun Yat‐sen University Guangzhou ChinaDepartment of Neurology Third Affiliated HospitalSun Yat‐sen University Guangzhou ChinaDepartment of Neurology Third Affiliated HospitalSun Yat‐sen University Guangzhou ChinaDepartment of Neurology Third Affiliated HospitalSun Yat‐sen University Guangzhou ChinaDepartment of Neurology Third Affiliated HospitalSun Yat‐sen University Guangzhou ChinaSchool of Mathematics Sun Yat‐sen University Guangzhou ChinaZhongshan Ophthalmic CenterSun Yat‐sen University Guangzhou ChinaDepartment of Neurology Third Affiliated HospitalSun Yat‐sen University Guangzhou ChinaAbstract Introduction The aim was to characterize the optical coherence tomography (OCT) angiography measures in patients with multiple sclerosis (MS) and neuromyelitis optica spectrum disorder (NMOSD) and to evaluate their disease discrimination capacity. Methods Patients with MS (n = 83) and AQP4‐IgG‐seropositive NMOSD (n = 91) with or without a history of optic neuritis, together with healthy controls (n = 34), were imaged. The main outcome measures were peripapillary retinal nerve fiber layer (pRNFL) thickness, macular ganglion cell‐inner plexiform layer (GC‐IPL) thickness, macular vessel density (VD), and perfusion density (PD) in the superficial capillary plexus. Diagnostic accuracy was assessed using the area under the receiver operating characteristics curve. Results Compared with patients with MS, those with NMOSD had a significantly smaller average thickness of the pRNFL and GC‐IPL (80.0 [59.0; 95.8] μm versus 92.0 [80.2; 101] μm, p < .001; 68.0 [56.0; 81.0] μm, versus 74.5 [64.2; 81.0] μm, p < .001) and significantly smaller whole VD and PD areas (15.6 [12.6; 17.0] mm−1 versus 16.7 [14.8; 17.7] mm−1, p < .001; 0.38 [0.31; 0.42] mm−1 versus 0.40 [0.37; 0.43] mm−1, p < .01). The combination of structural parameters (average thickness of the pRNFL and GC‐IPL) with microvascular parameters (temporal‐inner quadrant of VD, temporal‐inner, nasal‐inferior, and nasal‐outer quadrant of PD) was revealed to have a good diagnostic capability for discriminating between NMOSD and MS. Conclusions OCT angiography reveals different structural and microvascular retinal changes in MS and AQP4‐IgG‐seropositive NMOSD. These combined structural and microvascular parameters might be promising biomarkers for disease diagnosis.https://doi.org/10.1002/brb3.2125multiple sclerosisneuromyelitis optica spectrum disorderoptical coherence tomography angiography |
| spellingShingle | Chunxin Liu Hui Xiao Xiayin Zhang Yipeng Zhao Rui Li Xiaonan Zhong Yuge Wang Yaqing Shu Yanyu Chang Jingqi Wang Caixia Li Haotian Lin Wei Qiu Optical coherence tomography angiography helps distinguish multiple sclerosis from AQP4‐IgG‐seropositive neuromyelitis optica spectrum disorder Brain and Behavior multiple sclerosis neuromyelitis optica spectrum disorder optical coherence tomography angiography |
| title | Optical coherence tomography angiography helps distinguish multiple sclerosis from AQP4‐IgG‐seropositive neuromyelitis optica spectrum disorder |
| title_full | Optical coherence tomography angiography helps distinguish multiple sclerosis from AQP4‐IgG‐seropositive neuromyelitis optica spectrum disorder |
| title_fullStr | Optical coherence tomography angiography helps distinguish multiple sclerosis from AQP4‐IgG‐seropositive neuromyelitis optica spectrum disorder |
| title_full_unstemmed | Optical coherence tomography angiography helps distinguish multiple sclerosis from AQP4‐IgG‐seropositive neuromyelitis optica spectrum disorder |
| title_short | Optical coherence tomography angiography helps distinguish multiple sclerosis from AQP4‐IgG‐seropositive neuromyelitis optica spectrum disorder |
| title_sort | optical coherence tomography angiography helps distinguish multiple sclerosis from aqp4 igg seropositive neuromyelitis optica spectrum disorder |
| topic | multiple sclerosis neuromyelitis optica spectrum disorder optical coherence tomography angiography |
| url | https://doi.org/10.1002/brb3.2125 |
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