Translational Research in the Era of Precision Medicine: Where We Are and Where We Will Go
The advent of Precision Medicine has globally revolutionized the approach of translational research suggesting a patient-centric vision with therapeutic choices driven by the identification of specific predictive biomarkers of response to avoid ineffective therapies and reduce adverse effects. The s...
| Main Authors: | , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-03-01
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| Series: | Journal of Personalized Medicine |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2075-4426/11/3/216 |
| _version_ | 1797540918908157952 |
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| author | Ruggero De Maria Marchiano Gabriele Di Sante Geny Piro Carmine Carbone Giampaolo Tortora Luca Boldrini Antonella Pietragalla Gennaro Daniele Maria Tredicine Alfredo Cesario Vincenzo Valentini Daniela Gallo Gabriele Babini Marika D’Oria Giovanni Scambia |
| author_facet | Ruggero De Maria Marchiano Gabriele Di Sante Geny Piro Carmine Carbone Giampaolo Tortora Luca Boldrini Antonella Pietragalla Gennaro Daniele Maria Tredicine Alfredo Cesario Vincenzo Valentini Daniela Gallo Gabriele Babini Marika D’Oria Giovanni Scambia |
| author_sort | Ruggero De Maria Marchiano |
| collection | DOAJ |
| description | The advent of Precision Medicine has globally revolutionized the approach of translational research suggesting a patient-centric vision with therapeutic choices driven by the identification of specific predictive biomarkers of response to avoid ineffective therapies and reduce adverse effects. The spread of “multi-omics” analysis and the use of sensors, together with the ability to acquire clinical, behavioral, and environmental information on a large scale, will allow the digitization of the state of health or disease of each person, and the creation of a global health management system capable of generating real-time knowledge and new opportunities for prevention and therapy in the individual person (high-definition medicine). Real world data-based translational applications represent a promising alternative to the traditional evidence-based medicine (EBM) approaches that are based on the use of randomized clinical trials to test the selected hypothesis. Multi-modality data integration is necessary for example in precision oncology where an Avatar interface allows several simulations in order to define the best therapeutic scheme for each cancer patient. |
| first_indexed | 2024-03-10T13:07:55Z |
| format | Article |
| id | doaj.art-924f7d6a3b374bffb80f7e05d9983141 |
| institution | Directory Open Access Journal |
| issn | 2075-4426 |
| language | English |
| last_indexed | 2024-03-10T13:07:55Z |
| publishDate | 2021-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Personalized Medicine |
| spelling | doaj.art-924f7d6a3b374bffb80f7e05d99831412023-11-21T10:58:56ZengMDPI AGJournal of Personalized Medicine2075-44262021-03-0111321610.3390/jpm11030216Translational Research in the Era of Precision Medicine: Where We Are and Where We Will GoRuggero De Maria Marchiano0Gabriele Di Sante1Geny Piro2Carmine Carbone3Giampaolo Tortora4Luca Boldrini5Antonella Pietragalla6Gennaro Daniele7Maria Tredicine8Alfredo Cesario9Vincenzo Valentini10Daniela Gallo11Gabriele Babini12Marika D’Oria13Giovanni Scambia14Department of Translational Medicine and Surgery, Section of General Pathology, Università Cattolica del Sacro Cuore, 00168 Rome, ItalyDepartment of Translational Medicine and Surgery, Section of General Pathology, Università Cattolica del Sacro Cuore, 00168 Rome, ItalyComprehensive Cancer Center—Fondazione Policlinico Universitario A. Gemelli IRCCS, 00168 Rome, ItalyComprehensive Cancer Center—Fondazione Policlinico Universitario A. Gemelli IRCCS, 00168 Rome, ItalyComprehensive Cancer Center—Fondazione Policlinico Universitario A. Gemelli IRCCS, 00168 Rome, ItalyComprehensive Cancer Center—Fondazione Policlinico Universitario A. Gemelli IRCCS, 00168 Rome, ItalyComprehensive Cancer Center—Fondazione Policlinico Universitario A. Gemelli IRCCS, 00168 Rome, ItalyComprehensive Cancer Center—Fondazione Policlinico Universitario A. Gemelli IRCCS, 00168 Rome, ItalyDepartment of Translational Medicine and Surgery, Section of General Pathology, Università Cattolica del Sacro Cuore, 00168 Rome, ItalyScientific Direction, Fondazione Policlinico Universitario A. Gemelli IRCCS, 00168 Rome, ItalyComprehensive Cancer Center—Fondazione Policlinico Universitario A. Gemelli IRCCS, 00168 Rome, ItalyComprehensive Cancer Center—Fondazione Policlinico Universitario A. Gemelli IRCCS, 00168 Rome, ItalyComprehensive Cancer Center—Fondazione Policlinico Universitario A. Gemelli IRCCS, 00168 Rome, ItalyScientific Direction, Fondazione Policlinico Universitario A. Gemelli IRCCS, 00168 Rome, ItalyScientific Direction, Fondazione Policlinico Universitario A. Gemelli IRCCS, 00168 Rome, ItalyThe advent of Precision Medicine has globally revolutionized the approach of translational research suggesting a patient-centric vision with therapeutic choices driven by the identification of specific predictive biomarkers of response to avoid ineffective therapies and reduce adverse effects. The spread of “multi-omics” analysis and the use of sensors, together with the ability to acquire clinical, behavioral, and environmental information on a large scale, will allow the digitization of the state of health or disease of each person, and the creation of a global health management system capable of generating real-time knowledge and new opportunities for prevention and therapy in the individual person (high-definition medicine). Real world data-based translational applications represent a promising alternative to the traditional evidence-based medicine (EBM) approaches that are based on the use of randomized clinical trials to test the selected hypothesis. Multi-modality data integration is necessary for example in precision oncology where an Avatar interface allows several simulations in order to define the best therapeutic scheme for each cancer patient.https://www.mdpi.com/2075-4426/11/3/216omicspersonalized medicinePrecision Medicinehigh-definition medicine |
| spellingShingle | Ruggero De Maria Marchiano Gabriele Di Sante Geny Piro Carmine Carbone Giampaolo Tortora Luca Boldrini Antonella Pietragalla Gennaro Daniele Maria Tredicine Alfredo Cesario Vincenzo Valentini Daniela Gallo Gabriele Babini Marika D’Oria Giovanni Scambia Translational Research in the Era of Precision Medicine: Where We Are and Where We Will Go Journal of Personalized Medicine omics personalized medicine Precision Medicine high-definition medicine |
| title | Translational Research in the Era of Precision Medicine: Where We Are and Where We Will Go |
| title_full | Translational Research in the Era of Precision Medicine: Where We Are and Where We Will Go |
| title_fullStr | Translational Research in the Era of Precision Medicine: Where We Are and Where We Will Go |
| title_full_unstemmed | Translational Research in the Era of Precision Medicine: Where We Are and Where We Will Go |
| title_short | Translational Research in the Era of Precision Medicine: Where We Are and Where We Will Go |
| title_sort | translational research in the era of precision medicine where we are and where we will go |
| topic | omics personalized medicine Precision Medicine high-definition medicine |
| url | https://www.mdpi.com/2075-4426/11/3/216 |
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