Inhibition is a prevalent mode of activity in the neocortex around awake hippocampal ripples in mice
Coordinated peri-ripple activity in the hippocampal-neocortical network is essential for mnemonic information processing in the brain. Hippocampal ripples likely serve different functions in sleep and awake states. Thus, the corresponding neocortical activity patterns may differ in important ways. W...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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eLife Sciences Publications Ltd
2023-01-01
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| Series: | eLife |
| Subjects: | |
| Online Access: | https://elifesciences.org/articles/79513 |
| _version_ | 1797943385473941504 |
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| author | Javad Karimi Abadchi Zahra Rezaei Thomas Knöpfel Bruce L McNaughton Majid H Mohajerani |
| author_facet | Javad Karimi Abadchi Zahra Rezaei Thomas Knöpfel Bruce L McNaughton Majid H Mohajerani |
| author_sort | Javad Karimi Abadchi |
| collection | DOAJ |
| description | Coordinated peri-ripple activity in the hippocampal-neocortical network is essential for mnemonic information processing in the brain. Hippocampal ripples likely serve different functions in sleep and awake states. Thus, the corresponding neocortical activity patterns may differ in important ways. We addressed this possibility by conducting voltage and glutamate wide-field imaging of the neocortex with concurrent hippocampal electrophysiology in awake mice. Contrary to our previously published sleep results, deactivation and activation were dominant in post-ripple neocortical voltage and glutamate activity, respectively, especially in the agranular retrosplenial cortex (aRSC). Additionally, the spiking activity of aRSC neurons, estimated by two-photon calcium imaging, revealed the existence of two subpopulations of excitatory neurons with opposite peri-ripple modulation patterns: one increases and the other decreases firing rate. These differences in peri-ripple spatiotemporal patterns of neocortical activity in sleep versus awake states might underlie the reported differences in the function of sleep versus awake ripples. |
| first_indexed | 2024-04-10T20:22:13Z |
| format | Article |
| id | doaj.art-924fdffa35ba468786103704aebc9906 |
| institution | Directory Open Access Journal |
| issn | 2050-084X |
| language | English |
| last_indexed | 2024-04-10T20:22:13Z |
| publishDate | 2023-01-01 |
| publisher | eLife Sciences Publications Ltd |
| record_format | Article |
| series | eLife |
| spelling | doaj.art-924fdffa35ba468786103704aebc99062023-01-25T15:11:24ZengeLife Sciences Publications LtdeLife2050-084X2023-01-011210.7554/eLife.79513Inhibition is a prevalent mode of activity in the neocortex around awake hippocampal ripples in miceJavad Karimi Abadchi0https://orcid.org/0000-0003-4175-7598Zahra Rezaei1Thomas Knöpfel2https://orcid.org/0000-0002-5718-0765Bruce L McNaughton3Majid H Mohajerani4https://orcid.org/0000-0003-0964-2977Canadian Centre for Behavioral Neuroscience, University of Lethbridge, Lethbridge, CanadaCanadian Centre for Behavioral Neuroscience, University of Lethbridge, Lethbridge, CanadaLaboratory for Neuronal Circuit Dynamics, Imperial College London, London, United Kingdom; Department of Physics, Hong Kong Baptist University, Kowloon Tong, Hong KongCanadian Centre for Behavioral Neuroscience, University of Lethbridge, Lethbridge, Canada; Department of Neurobiology and Behavior, University of California, Irvine, United StatesCanadian Centre for Behavioral Neuroscience, University of Lethbridge, Lethbridge, CanadaCoordinated peri-ripple activity in the hippocampal-neocortical network is essential for mnemonic information processing in the brain. Hippocampal ripples likely serve different functions in sleep and awake states. Thus, the corresponding neocortical activity patterns may differ in important ways. We addressed this possibility by conducting voltage and glutamate wide-field imaging of the neocortex with concurrent hippocampal electrophysiology in awake mice. Contrary to our previously published sleep results, deactivation and activation were dominant in post-ripple neocortical voltage and glutamate activity, respectively, especially in the agranular retrosplenial cortex (aRSC). Additionally, the spiking activity of aRSC neurons, estimated by two-photon calcium imaging, revealed the existence of two subpopulations of excitatory neurons with opposite peri-ripple modulation patterns: one increases and the other decreases firing rate. These differences in peri-ripple spatiotemporal patterns of neocortical activity in sleep versus awake states might underlie the reported differences in the function of sleep versus awake ripples.https://elifesciences.org/articles/79513hippocampusneocortexhippocampal-neocortical interactionmemory consolidationsharp-wave ripplevoltage/glutamate/calcium imaging |
| spellingShingle | Javad Karimi Abadchi Zahra Rezaei Thomas Knöpfel Bruce L McNaughton Majid H Mohajerani Inhibition is a prevalent mode of activity in the neocortex around awake hippocampal ripples in mice eLife hippocampus neocortex hippocampal-neocortical interaction memory consolidation sharp-wave ripple voltage/glutamate/calcium imaging |
| title | Inhibition is a prevalent mode of activity in the neocortex around awake hippocampal ripples in mice |
| title_full | Inhibition is a prevalent mode of activity in the neocortex around awake hippocampal ripples in mice |
| title_fullStr | Inhibition is a prevalent mode of activity in the neocortex around awake hippocampal ripples in mice |
| title_full_unstemmed | Inhibition is a prevalent mode of activity in the neocortex around awake hippocampal ripples in mice |
| title_short | Inhibition is a prevalent mode of activity in the neocortex around awake hippocampal ripples in mice |
| title_sort | inhibition is a prevalent mode of activity in the neocortex around awake hippocampal ripples in mice |
| topic | hippocampus neocortex hippocampal-neocortical interaction memory consolidation sharp-wave ripple voltage/glutamate/calcium imaging |
| url | https://elifesciences.org/articles/79513 |
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