Connectivity-Based Brain Network Supports Restricted and Repetitive Behaviors in Autism Spectrum Disorder Across Development
IntroductionAutism spectrum disorder (ASD) is a lifelong condition. Autistic symptoms can persist into adulthood. Studies have reported that autistic symptoms generally improved in adulthood, especially restricted and repetitive behaviors and interests (RRBIs). We explored brain networks that are re...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-03-01
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| Series: | Frontiers in Psychiatry |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fpsyt.2022.874090/full |
| _version_ | 1819178984929230848 |
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| author | Anyi Zhang Lin Liu Lin Liu Suhua Chang Le Shi Peng Li Jie Shi Lin Lu Lin Lu Yanping Bao Yanping Bao Jiajia Liu |
| author_facet | Anyi Zhang Lin Liu Lin Liu Suhua Chang Le Shi Peng Li Jie Shi Lin Lu Lin Lu Yanping Bao Yanping Bao Jiajia Liu |
| author_sort | Anyi Zhang |
| collection | DOAJ |
| description | IntroductionAutism spectrum disorder (ASD) is a lifelong condition. Autistic symptoms can persist into adulthood. Studies have reported that autistic symptoms generally improved in adulthood, especially restricted and repetitive behaviors and interests (RRBIs). We explored brain networks that are related to differences in RRBIs in individuals with ASDs among different ages.MethodsWe enrolled 147 ASD patients from the Autism Brain Imaging Data Exchange II (ABIDEII) database. The participants were divided into four age groups: children (6–9 years old), younger adolescents (10–14 years old), older adolescents (15–19 years old), and adults (≥20 years old). RRBIs were evaluated using the Repetitive Behaviors Scale-Revised 6. We first explored differences in RRBIs between age groups using the Kruskal–Wallis test. Associations between improvements in RRBIs and age were analyzed using a general linear model. We then analyzed RRBIs associated functional connectivity (FC) links using the network-based statistic method by adjusting covariates. The association of the identified FC with age group, and mediation function of the FC on the association of age-group and RRBI were further analyzed.ResultsMost subtypes of RRBIs improved with age, especially stereotyped behaviors, ritualistic behaviors, and restricted behaviors (p = 0.012, 0.014, and 0.012, respectively). Results showed that 12 FC links were closely related to overall RRBIs, 17 FC links were related to stereotyped behaviors. Among the identified 29 FC links, 15 were negatively related to age-groups. The mostly reported core brain regions included superior occipital gyrus, insula, rolandic operculum, angular, caudate, and cingulum. The decrease in FC between the left superior occipital lobe and right angular (effect = −0.125 and −0.693, respectively) and between the left insula and left caudate (effect = −0.116 and −0.664, respectively) might contribute to improvements in multiple RRBIs with age.ConclusionWe identified improvements in RRBIs with age in ASD patients, especially stereotyped behaviors, ritualistic behaviors, and restricted behaviors. The decrease in FC between left superior occipital lobe and right angular and between left insula and left caudate might contribute to these improvements. Our findings improve our understanding of the pathogenesis of RRBIs and suggest potential intervention targets to improve prognosis in adulthood. |
| first_indexed | 2024-12-22T21:51:14Z |
| format | Article |
| id | doaj.art-924fe3e1e9e84df396791a380a96d75d |
| institution | Directory Open Access Journal |
| issn | 1664-0640 |
| language | English |
| last_indexed | 2024-12-22T21:51:14Z |
| publishDate | 2022-03-01 |
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| series | Frontiers in Psychiatry |
| spelling | doaj.art-924fe3e1e9e84df396791a380a96d75d2022-12-21T18:11:21ZengFrontiers Media S.A.Frontiers in Psychiatry1664-06402022-03-011310.3389/fpsyt.2022.874090874090Connectivity-Based Brain Network Supports Restricted and Repetitive Behaviors in Autism Spectrum Disorder Across DevelopmentAnyi Zhang0Lin Liu1Lin Liu2Suhua Chang3Le Shi4Peng Li5Jie Shi6Lin Lu7Lin Lu8Yanping Bao9Yanping Bao10Jiajia Liu11Peking University Sixth Hospital, Peking University Institute of Mental Health, NHC Key Laboratory of Mental Health (Peking University), National Clinical Research Center for Mental Disorders (Peking University Sixth Hospital), Peking University, Beijing, ChinaPeking University Sixth Hospital, Peking University Institute of Mental Health, NHC Key Laboratory of Mental Health (Peking University), National Clinical Research Center for Mental Disorders (Peking University Sixth Hospital), Peking University, Beijing, ChinaNational Institute on Drug Dependence and Beijing Key Laboratory on Drug Dependence Research, Peking University, Beijing, ChinaPeking University Sixth Hospital, Peking University Institute of Mental Health, NHC Key Laboratory of Mental Health (Peking University), National Clinical Research Center for Mental Disorders (Peking University Sixth Hospital), Peking University, Beijing, ChinaPeking University Sixth Hospital, Peking University Institute of Mental Health, NHC Key Laboratory of Mental Health (Peking University), National Clinical Research Center for Mental Disorders (Peking University Sixth Hospital), Peking University, Beijing, ChinaPeking University Sixth Hospital, Peking University Institute of Mental Health, NHC Key Laboratory of Mental Health (Peking University), National Clinical Research Center for Mental Disorders (Peking University Sixth Hospital), Peking University, Beijing, ChinaNational Institute on Drug Dependence and Beijing Key Laboratory on Drug Dependence Research, Peking University, Beijing, ChinaPeking University Sixth Hospital, Peking University Institute of Mental Health, NHC Key Laboratory of Mental Health (Peking University), National Clinical Research Center for Mental Disorders (Peking University Sixth Hospital), Peking University, Beijing, ChinaPeking-Tsinghua Centre for Life Sciences and PKU-IDG/McGovern Institute for Brain Research, Peking University, Beijing, ChinaNational Institute on Drug Dependence and Beijing Key Laboratory on Drug Dependence Research, Peking University, Beijing, ChinaSchool of Public Health, Peking University, Beijing, ChinaSchool of Nursing, Peking University, Beijing, ChinaIntroductionAutism spectrum disorder (ASD) is a lifelong condition. Autistic symptoms can persist into adulthood. Studies have reported that autistic symptoms generally improved in adulthood, especially restricted and repetitive behaviors and interests (RRBIs). We explored brain networks that are related to differences in RRBIs in individuals with ASDs among different ages.MethodsWe enrolled 147 ASD patients from the Autism Brain Imaging Data Exchange II (ABIDEII) database. The participants were divided into four age groups: children (6–9 years old), younger adolescents (10–14 years old), older adolescents (15–19 years old), and adults (≥20 years old). RRBIs were evaluated using the Repetitive Behaviors Scale-Revised 6. We first explored differences in RRBIs between age groups using the Kruskal–Wallis test. Associations between improvements in RRBIs and age were analyzed using a general linear model. We then analyzed RRBIs associated functional connectivity (FC) links using the network-based statistic method by adjusting covariates. The association of the identified FC with age group, and mediation function of the FC on the association of age-group and RRBI were further analyzed.ResultsMost subtypes of RRBIs improved with age, especially stereotyped behaviors, ritualistic behaviors, and restricted behaviors (p = 0.012, 0.014, and 0.012, respectively). Results showed that 12 FC links were closely related to overall RRBIs, 17 FC links were related to stereotyped behaviors. Among the identified 29 FC links, 15 were negatively related to age-groups. The mostly reported core brain regions included superior occipital gyrus, insula, rolandic operculum, angular, caudate, and cingulum. The decrease in FC between the left superior occipital lobe and right angular (effect = −0.125 and −0.693, respectively) and between the left insula and left caudate (effect = −0.116 and −0.664, respectively) might contribute to improvements in multiple RRBIs with age.ConclusionWe identified improvements in RRBIs with age in ASD patients, especially stereotyped behaviors, ritualistic behaviors, and restricted behaviors. The decrease in FC between left superior occipital lobe and right angular and between left insula and left caudate might contribute to these improvements. Our findings improve our understanding of the pathogenesis of RRBIs and suggest potential intervention targets to improve prognosis in adulthood.https://www.frontiersin.org/articles/10.3389/fpsyt.2022.874090/fullautism spectrum disorderbrain networksnetwork-based statisticrestricted and repetitive behaviorsmediation analysis |
| spellingShingle | Anyi Zhang Lin Liu Lin Liu Suhua Chang Le Shi Peng Li Jie Shi Lin Lu Lin Lu Yanping Bao Yanping Bao Jiajia Liu Connectivity-Based Brain Network Supports Restricted and Repetitive Behaviors in Autism Spectrum Disorder Across Development Frontiers in Psychiatry autism spectrum disorder brain networks network-based statistic restricted and repetitive behaviors mediation analysis |
| title | Connectivity-Based Brain Network Supports Restricted and Repetitive Behaviors in Autism Spectrum Disorder Across Development |
| title_full | Connectivity-Based Brain Network Supports Restricted and Repetitive Behaviors in Autism Spectrum Disorder Across Development |
| title_fullStr | Connectivity-Based Brain Network Supports Restricted and Repetitive Behaviors in Autism Spectrum Disorder Across Development |
| title_full_unstemmed | Connectivity-Based Brain Network Supports Restricted and Repetitive Behaviors in Autism Spectrum Disorder Across Development |
| title_short | Connectivity-Based Brain Network Supports Restricted and Repetitive Behaviors in Autism Spectrum Disorder Across Development |
| title_sort | connectivity based brain network supports restricted and repetitive behaviors in autism spectrum disorder across development |
| topic | autism spectrum disorder brain networks network-based statistic restricted and repetitive behaviors mediation analysis |
| url | https://www.frontiersin.org/articles/10.3389/fpsyt.2022.874090/full |
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