Does Curcumin Have a Role in the Interaction between Gut Microbiota and <i>Schistosoma mansoni</i> in Mice?
There is strong correlation between changes in abundance of specific bacterial species and several diseases including schistosomiasis. Several studies have described therapeutic effects of curcumin (CUR) which may arise from its regulative effects on intestinal microbiota. Thus, we examined the impa...
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MDPI AG
2020-09-01
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| Series: | Pathogens |
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| Online Access: | https://www.mdpi.com/2076-0817/9/9/767 |
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| author | Assmaa Anter Mohamed Abd El-Ghany Marwa Abou El Dahab Noha Mahana |
| author_facet | Assmaa Anter Mohamed Abd El-Ghany Marwa Abou El Dahab Noha Mahana |
| author_sort | Assmaa Anter |
| collection | DOAJ |
| description | There is strong correlation between changes in abundance of specific bacterial species and several diseases including schistosomiasis. Several studies have described therapeutic effects of curcumin (CUR) which may arise from its regulative effects on intestinal microbiota. Thus, we examined the impact of CUR on the diversity of intestinal microbiota with/without infection by <i>Schistosoma mansoni</i> cercariae for 56 days. Enterobacteriaceae was dominating in a naive and <i>S. mansoni</i> infected mice group without CUR treatment, the most predominant species was <i>Escherichia coli</i> with relative density (R.D%) = 80.66% and the least one was <i>Pseudomonas sp</i>. (0.52%). The influence of CUR on murine microbiota composition was examined one week after oral administration of high (40) and low (20 mg/kg b.w.) CUR doses were administered three times, with two day intervals. CUR induced high variation in the Enterobacteriaceae family, characterized by a significant (<i>p</i> < 0.001) reduction in <i>E. coli</i> and asignificant (<i>p</i> < 0.001) increase in <i>Pseudomonas sp.</i> in both naïve and <i>S. mansoni</i>-infected mice, compared to untreated mice, in a dose-dependent manner. Additionally, our study showed the effects of high CUR doses on <i>S. mansoni</i> infection immunological and parasitological parameters. These data support CUR’s ability to promote <i>Pseudomonas sp.</i> known to produce schistosomicidal toxins and offset the sequelae of murine schistosomiasis. |
| first_indexed | 2024-03-10T16:12:46Z |
| format | Article |
| id | doaj.art-9250a7e32efc492d9891c79543b1d7ee |
| institution | Directory Open Access Journal |
| issn | 2076-0817 |
| language | English |
| last_indexed | 2024-03-10T16:12:46Z |
| publishDate | 2020-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pathogens |
| spelling | doaj.art-9250a7e32efc492d9891c79543b1d7ee2023-11-20T14:21:49ZengMDPI AGPathogens2076-08172020-09-019976710.3390/pathogens9090767Does Curcumin Have a Role in the Interaction between Gut Microbiota and <i>Schistosoma mansoni</i> in Mice?Assmaa Anter0Mohamed Abd El-Ghany1Marwa Abou El Dahab2Noha Mahana3Zoology Department, Faculty of Science, Cairo University, Giza 12613, EgyptBotany and Microbiology Department, Faculty of Science, Cairo University, Giza 12613, EgyptZoology Department, Faculty of Science, Ain Shams University, Cairo 11566, EgyptZoology Department, Faculty of Science, Cairo University, Giza 12613, EgyptThere is strong correlation between changes in abundance of specific bacterial species and several diseases including schistosomiasis. Several studies have described therapeutic effects of curcumin (CUR) which may arise from its regulative effects on intestinal microbiota. Thus, we examined the impact of CUR on the diversity of intestinal microbiota with/without infection by <i>Schistosoma mansoni</i> cercariae for 56 days. Enterobacteriaceae was dominating in a naive and <i>S. mansoni</i> infected mice group without CUR treatment, the most predominant species was <i>Escherichia coli</i> with relative density (R.D%) = 80.66% and the least one was <i>Pseudomonas sp</i>. (0.52%). The influence of CUR on murine microbiota composition was examined one week after oral administration of high (40) and low (20 mg/kg b.w.) CUR doses were administered three times, with two day intervals. CUR induced high variation in the Enterobacteriaceae family, characterized by a significant (<i>p</i> < 0.001) reduction in <i>E. coli</i> and asignificant (<i>p</i> < 0.001) increase in <i>Pseudomonas sp.</i> in both naïve and <i>S. mansoni</i>-infected mice, compared to untreated mice, in a dose-dependent manner. Additionally, our study showed the effects of high CUR doses on <i>S. mansoni</i> infection immunological and parasitological parameters. These data support CUR’s ability to promote <i>Pseudomonas sp.</i> known to produce schistosomicidal toxins and offset the sequelae of murine schistosomiasis.https://www.mdpi.com/2076-0817/9/9/767<i>Schistosoma mansoni</i>curcuminmouse gut microbiota<i>Pseudomonas aeruginosa</i>immune responsesparasitological parameters |
| spellingShingle | Assmaa Anter Mohamed Abd El-Ghany Marwa Abou El Dahab Noha Mahana Does Curcumin Have a Role in the Interaction between Gut Microbiota and <i>Schistosoma mansoni</i> in Mice? Pathogens <i>Schistosoma mansoni</i> curcumin mouse gut microbiota <i>Pseudomonas aeruginosa</i> immune responses parasitological parameters |
| title | Does Curcumin Have a Role in the Interaction between Gut Microbiota and <i>Schistosoma mansoni</i> in Mice? |
| title_full | Does Curcumin Have a Role in the Interaction between Gut Microbiota and <i>Schistosoma mansoni</i> in Mice? |
| title_fullStr | Does Curcumin Have a Role in the Interaction between Gut Microbiota and <i>Schistosoma mansoni</i> in Mice? |
| title_full_unstemmed | Does Curcumin Have a Role in the Interaction between Gut Microbiota and <i>Schistosoma mansoni</i> in Mice? |
| title_short | Does Curcumin Have a Role in the Interaction between Gut Microbiota and <i>Schistosoma mansoni</i> in Mice? |
| title_sort | does curcumin have a role in the interaction between gut microbiota and i schistosoma mansoni i in mice |
| topic | <i>Schistosoma mansoni</i> curcumin mouse gut microbiota <i>Pseudomonas aeruginosa</i> immune responses parasitological parameters |
| url | https://www.mdpi.com/2076-0817/9/9/767 |
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