The Endoplasmic Reticulum-Mitochondrion Tether ERMES Orchestrates Fungal Immune Evasion, Illuminating Inflammasome Responses to Hyphal Signals

The Endoplasmic Reticulum-Mitochondrion Tether ERMES Orchestrates Fungal Immune Evasion, Illuminating Inflammasome Responses to Hyphal Signals

ABSTRACT The pathogenic yeast Candida albicans escapes macrophages by triggering NLRP3 inflammasome-dependent host cell death (pyroptosis). Pyroptosis is inflammatory and must be tightly regulated by host and microbe, but the mechanism is incompletely defined. We characterized the C. albicans endopl...

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Bibliographic Details
Main Authors: Timothy M. Tucey, Jiyoti Verma-Gaur, Julie Nguyen, Victoria L. Hewitt, Tricia L. Lo, Miguel Shingu-Vazquez, Avril A. B. Robertson, James R. Hill, Filomena A. Pettolino, Travis Beddoe, Matthew A. Cooper, Thomas Naderer, Ana Traven
Format: Article
Language:English
Published: American Society for Microbiology 2016-06-01
Series:mSphere
Subjects:
Candida albicans
macrophage
metabolism
mitochondria
Online Access:https://journals.asm.org/doi/10.1128/mSphere.00074-16

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