Interactions among Long Non-Coding RNAs and microRNAs Influence Disease Phenotype in Diabetes and Diabetic Kidney Disease
Large-scale RNA sequencing and genome-wide profiling data revealed the identification of a heterogeneous group of noncoding RNAs, known as long noncoding RNAs (lncRNAs). These lncRNAs play central roles in health and disease processes in diabetes and cancer. The critical association between aberrant...
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| Format: | Article |
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MDPI AG
2021-06-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/22/11/6027 |
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| author | Swayam Prakash Srivastava Julie E. Goodwin Pratima Tripathi Keizo Kanasaki Daisuke Koya |
| author_facet | Swayam Prakash Srivastava Julie E. Goodwin Pratima Tripathi Keizo Kanasaki Daisuke Koya |
| author_sort | Swayam Prakash Srivastava |
| collection | DOAJ |
| description | Large-scale RNA sequencing and genome-wide profiling data revealed the identification of a heterogeneous group of noncoding RNAs, known as long noncoding RNAs (lncRNAs). These lncRNAs play central roles in health and disease processes in diabetes and cancer. The critical association between aberrant expression of lncRNAs in diabetes and diabetic kidney disease have been reported. LncRNAs regulate diverse targets and can function as sponges for regulatory microRNAs, which influence disease phenotype in the kidneys. Importantly, lncRNAs and microRNAs may regulate bidirectional or crosstalk mechanisms, which need to be further investigated. These studies offer the novel possibility that lncRNAs may be used as potential therapeutic targets for diabetes and diabetic kidney diseases. Here, we discuss the functions and mechanisms of actions of lncRNAs, and their crosstalk interactions with microRNAs, which provide insight and promise as therapeutic targets, emphasizing their role in the pathogenesis of diabetes and diabetic kidney disease |
| first_indexed | 2024-03-10T10:46:00Z |
| format | Article |
| id | doaj.art-92513fb4a86a4f02a0387442d9aba2ff |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T10:46:00Z |
| publishDate | 2021-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-92513fb4a86a4f02a0387442d9aba2ff2023-11-21T22:36:21ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672021-06-012211602710.3390/ijms22116027Interactions among Long Non-Coding RNAs and microRNAs Influence Disease Phenotype in Diabetes and Diabetic Kidney DiseaseSwayam Prakash Srivastava0Julie E. Goodwin1Pratima Tripathi2Keizo Kanasaki3Daisuke Koya4Department of Pediatrics, Yale University School of Medicine, New Haven, CT 06511, USADepartment of Pediatrics, Yale University School of Medicine, New Haven, CT 06511, USADepartment of Biochemistry, Dr. Ram Manohar Lohia Institute of Medical Sciences, Lucknow 226010, IndiaInternal Medicine 1, Shimane University Faculty of Medicine, Izumo 693-0021, JapanDepartment of Diabetology and Endocrinology, Kanazawa Medical University, Ishikawa 920-0293, JapanLarge-scale RNA sequencing and genome-wide profiling data revealed the identification of a heterogeneous group of noncoding RNAs, known as long noncoding RNAs (lncRNAs). These lncRNAs play central roles in health and disease processes in diabetes and cancer. The critical association between aberrant expression of lncRNAs in diabetes and diabetic kidney disease have been reported. LncRNAs regulate diverse targets and can function as sponges for regulatory microRNAs, which influence disease phenotype in the kidneys. Importantly, lncRNAs and microRNAs may regulate bidirectional or crosstalk mechanisms, which need to be further investigated. These studies offer the novel possibility that lncRNAs may be used as potential therapeutic targets for diabetes and diabetic kidney diseases. Here, we discuss the functions and mechanisms of actions of lncRNAs, and their crosstalk interactions with microRNAs, which provide insight and promise as therapeutic targets, emphasizing their role in the pathogenesis of diabetes and diabetic kidney diseasehttps://www.mdpi.com/1422-0067/22/11/6027long noncoding RNAsmicroRNAs in kidneykidney fibrosisEMTEndMTdiabetes mellitus |
| spellingShingle | Swayam Prakash Srivastava Julie E. Goodwin Pratima Tripathi Keizo Kanasaki Daisuke Koya Interactions among Long Non-Coding RNAs and microRNAs Influence Disease Phenotype in Diabetes and Diabetic Kidney Disease International Journal of Molecular Sciences long noncoding RNAs microRNAs in kidney kidney fibrosis EMT EndMT diabetes mellitus |
| title | Interactions among Long Non-Coding RNAs and microRNAs Influence Disease Phenotype in Diabetes and Diabetic Kidney Disease |
| title_full | Interactions among Long Non-Coding RNAs and microRNAs Influence Disease Phenotype in Diabetes and Diabetic Kidney Disease |
| title_fullStr | Interactions among Long Non-Coding RNAs and microRNAs Influence Disease Phenotype in Diabetes and Diabetic Kidney Disease |
| title_full_unstemmed | Interactions among Long Non-Coding RNAs and microRNAs Influence Disease Phenotype in Diabetes and Diabetic Kidney Disease |
| title_short | Interactions among Long Non-Coding RNAs and microRNAs Influence Disease Phenotype in Diabetes and Diabetic Kidney Disease |
| title_sort | interactions among long non coding rnas and micrornas influence disease phenotype in diabetes and diabetic kidney disease |
| topic | long noncoding RNAs microRNAs in kidney kidney fibrosis EMT EndMT diabetes mellitus |
| url | https://www.mdpi.com/1422-0067/22/11/6027 |
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