Oxygen saturation levels and retinopathy of prematurity in extremely preterm infants - a case control study
Abstract Purpose To investigate the association of risk factors, including oxygen exposure, for developing retinopathy of prematurity (ROP) in preterm infants at increased risk of ROP. Methods A case-control study was conducted where each infant born at < 28 weeks gestation with ROP was matched w...
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| Format: | Article |
| Language: | English |
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BMC
2023-09-01
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| Series: | BMC Pediatrics |
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| Online Access: | https://doi.org/10.1186/s12887-023-04278-6 |
| _version_ | 1797451489936932864 |
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| author | Varnika Aggarwal Risha Bhatia Kenneth Tan |
| author_facet | Varnika Aggarwal Risha Bhatia Kenneth Tan |
| author_sort | Varnika Aggarwal |
| collection | DOAJ |
| description | Abstract Purpose To investigate the association of risk factors, including oxygen exposure, for developing retinopathy of prematurity (ROP) in preterm infants at increased risk of ROP. Methods A case-control study was conducted where each infant born at < 28 weeks gestation with ROP was matched with another without ROP over five years (July 2015 – June 2020). Clinical information about the infants was collected from electronic medical records, including method of oxygen delivery, oxygen saturation (SpO2), fraction of inspired oxygen (FiO2) and mean airway pressure (MAP) measurements. MATLAB was used for a time-averaged analysis. Stata/SE 16.0 was used for statistical analysis. Results 123 ROP/non-ROP pairs were included in this study. The time-averaged SpO2 analysis showed non-ROP group spent more time in hyperoxia than the ROP group (p < 0.001). The non-ROP group had lower respiratory severity scores and analysis when FiO2 > 21% showed that were was no difference in SpO2 between the two groups when the infants were receiving oxygen support. Conditional logistic regressions showed neonatal surgery significantly increased the risk of ROP (OR = 1.4347, p = 0.010), while the influence of birthweight (odds ratio of 0.9965, p = 0.001) and oxygen exposure (OR = 0.9983, p = 0.012) on ROP outcome was found to be negligible as their odds ratios indicated no influence. Conclusions At times when infants were receiving respiratory support (FiO2 > 21%) the SpO2 data indicated no difference in SpO2 between the ROP and non-ROP groups. Analysis of clinical variables found that neonatal surgery increased the odds of developing ROP. |
| first_indexed | 2024-03-09T14:54:22Z |
| format | Article |
| id | doaj.art-92525ffa080c4ecb9a4e8ebdb66d5407 |
| institution | Directory Open Access Journal |
| issn | 1471-2431 |
| language | English |
| last_indexed | 2024-03-09T14:54:22Z |
| publishDate | 2023-09-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Pediatrics |
| spelling | doaj.art-92525ffa080c4ecb9a4e8ebdb66d54072023-11-26T14:15:42ZengBMCBMC Pediatrics1471-24312023-09-012311910.1186/s12887-023-04278-6Oxygen saturation levels and retinopathy of prematurity in extremely preterm infants - a case control studyVarnika Aggarwal0Risha Bhatia1Kenneth Tan2Department of Paediatrics, Monash UniversityDepartment of Paediatrics, Monash UniversityDepartment of Paediatrics, Monash UniversityAbstract Purpose To investigate the association of risk factors, including oxygen exposure, for developing retinopathy of prematurity (ROP) in preterm infants at increased risk of ROP. Methods A case-control study was conducted where each infant born at < 28 weeks gestation with ROP was matched with another without ROP over five years (July 2015 – June 2020). Clinical information about the infants was collected from electronic medical records, including method of oxygen delivery, oxygen saturation (SpO2), fraction of inspired oxygen (FiO2) and mean airway pressure (MAP) measurements. MATLAB was used for a time-averaged analysis. Stata/SE 16.0 was used for statistical analysis. Results 123 ROP/non-ROP pairs were included in this study. The time-averaged SpO2 analysis showed non-ROP group spent more time in hyperoxia than the ROP group (p < 0.001). The non-ROP group had lower respiratory severity scores and analysis when FiO2 > 21% showed that were was no difference in SpO2 between the two groups when the infants were receiving oxygen support. Conditional logistic regressions showed neonatal surgery significantly increased the risk of ROP (OR = 1.4347, p = 0.010), while the influence of birthweight (odds ratio of 0.9965, p = 0.001) and oxygen exposure (OR = 0.9983, p = 0.012) on ROP outcome was found to be negligible as their odds ratios indicated no influence. Conclusions At times when infants were receiving respiratory support (FiO2 > 21%) the SpO2 data indicated no difference in SpO2 between the ROP and non-ROP groups. Analysis of clinical variables found that neonatal surgery increased the odds of developing ROP.https://doi.org/10.1186/s12887-023-04278-6InfantsNewborn; pretermRetinopathy of prematurityOxygen exposureOxygen saturation |
| spellingShingle | Varnika Aggarwal Risha Bhatia Kenneth Tan Oxygen saturation levels and retinopathy of prematurity in extremely preterm infants - a case control study BMC Pediatrics Infants Newborn; preterm Retinopathy of prematurity Oxygen exposure Oxygen saturation |
| title | Oxygen saturation levels and retinopathy of prematurity in extremely preterm infants - a case control study |
| title_full | Oxygen saturation levels and retinopathy of prematurity in extremely preterm infants - a case control study |
| title_fullStr | Oxygen saturation levels and retinopathy of prematurity in extremely preterm infants - a case control study |
| title_full_unstemmed | Oxygen saturation levels and retinopathy of prematurity in extremely preterm infants - a case control study |
| title_short | Oxygen saturation levels and retinopathy of prematurity in extremely preterm infants - a case control study |
| title_sort | oxygen saturation levels and retinopathy of prematurity in extremely preterm infants a case control study |
| topic | Infants Newborn; preterm Retinopathy of prematurity Oxygen exposure Oxygen saturation |
| url | https://doi.org/10.1186/s12887-023-04278-6 |
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