A Multifunctional Acoustic Tweezer for Heterogenous Assembloids Patterning
Acoustic tweezers, capable of complicated manipulation of bioparticles by acoustic radiation forces using a noninvasive and noncontact approach, are an innovative technology for patterning assemble organoids. Hence, acoustic tweezers exhibit considerable potential for forming programmable patterning...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley-VCH
2023-05-01
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| Series: | Small Structures |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/sstr.202200288 |
| _version_ | 1797772467835502592 |
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| author | Zeping Gao Shuo Wang Yufei Sui Qi Zhang Ye Yang Jiqing Huang Yucui Xiong Teng Ma Xiao Zhang Hairong Zheng |
| author_facet | Zeping Gao Shuo Wang Yufei Sui Qi Zhang Ye Yang Jiqing Huang Yucui Xiong Teng Ma Xiao Zhang Hairong Zheng |
| author_sort | Zeping Gao |
| collection | DOAJ |
| description | Acoustic tweezers, capable of complicated manipulation of bioparticles by acoustic radiation forces using a noninvasive and noncontact approach, are an innovative technology for patterning assemble organoids. Hence, acoustic tweezers exhibit considerable potential for forming programmable patterning of organoids with specific spatial structures. Furthermore, heterogeneous assembloids with complex arrangement patterns can be built through sequential assembling and culturing to explore polarized tissue development or disease metastasis in multiple organs. This study focuses on the structural assembly of organoids using an ultrasonic 2D matrix array to generate real‐time switching of different acoustic fields. In addition, a local renal injured assembloid is fabricated to study and verify its application in tissue engineering and disease modeling. |
| first_indexed | 2024-03-12T21:52:23Z |
| format | Article |
| id | doaj.art-92538dd831c641148133778a08012e16 |
| institution | Directory Open Access Journal |
| issn | 2688-4062 |
| language | English |
| last_indexed | 2024-03-12T21:52:23Z |
| publishDate | 2023-05-01 |
| publisher | Wiley-VCH |
| record_format | Article |
| series | Small Structures |
| spelling | doaj.art-92538dd831c641148133778a08012e162023-07-26T01:36:10ZengWiley-VCHSmall Structures2688-40622023-05-0145n/an/a10.1002/sstr.202200288A Multifunctional Acoustic Tweezer for Heterogenous Assembloids PatterningZeping Gao0Shuo Wang1Yufei Sui2Qi Zhang3Ye Yang4Jiqing Huang5Yucui Xiong6Teng Ma7Xiao Zhang8Hairong Zheng9Paul C. Lauterbur Research Center for Biomedical Imaging Shenzhen Institutes of Advanced Technology Chinese Academy of Sciences Shenzhen 518055 ChinaPaul C. Lauterbur Research Center for Biomedical Imaging Shenzhen Institutes of Advanced Technology Chinese Academy of Sciences Shenzhen 518055 ChinaCAS Key Laboratory of Regenerative Biology Joint School of Life Sciences Guangzhou Institutes of Biomedicine and Health Chinese Academy of Sciences Guangzhou Medical University Guangzhou 510530 ChinaPaul C. Lauterbur Research Center for Biomedical Imaging Shenzhen Institutes of Advanced Technology Chinese Academy of Sciences Shenzhen 518055 ChinaPaul C. Lauterbur Research Center for Biomedical Imaging Shenzhen Institutes of Advanced Technology Chinese Academy of Sciences Shenzhen 518055 ChinaPaul C. Lauterbur Research Center for Biomedical Imaging Shenzhen Institutes of Advanced Technology Chinese Academy of Sciences Shenzhen 518055 ChinaCAS Key Laboratory of Regenerative Biology Joint School of Life Sciences Guangzhou Institutes of Biomedicine and Health Chinese Academy of Sciences Guangzhou Medical University Guangzhou 510530 ChinaPaul C. Lauterbur Research Center for Biomedical Imaging Shenzhen Institutes of Advanced Technology Chinese Academy of Sciences Shenzhen 518055 ChinaCAS Key Laboratory of Regenerative Biology Joint School of Life Sciences Guangzhou Institutes of Biomedicine and Health Chinese Academy of Sciences Guangzhou Medical University Guangzhou 510530 ChinaPaul C. Lauterbur Research Center for Biomedical Imaging Shenzhen Institutes of Advanced Technology Chinese Academy of Sciences Shenzhen 518055 ChinaAcoustic tweezers, capable of complicated manipulation of bioparticles by acoustic radiation forces using a noninvasive and noncontact approach, are an innovative technology for patterning assemble organoids. Hence, acoustic tweezers exhibit considerable potential for forming programmable patterning of organoids with specific spatial structures. Furthermore, heterogeneous assembloids with complex arrangement patterns can be built through sequential assembling and culturing to explore polarized tissue development or disease metastasis in multiple organs. This study focuses on the structural assembly of organoids using an ultrasonic 2D matrix array to generate real‐time switching of different acoustic fields. In addition, a local renal injured assembloid is fabricated to study and verify its application in tissue engineering and disease modeling.https://doi.org/10.1002/sstr.202200288disease modelingheterogenous assembloidsholographic acoustic tweezersstem cell engineering |
| spellingShingle | Zeping Gao Shuo Wang Yufei Sui Qi Zhang Ye Yang Jiqing Huang Yucui Xiong Teng Ma Xiao Zhang Hairong Zheng A Multifunctional Acoustic Tweezer for Heterogenous Assembloids Patterning Small Structures disease modeling heterogenous assembloids holographic acoustic tweezers stem cell engineering |
| title | A Multifunctional Acoustic Tweezer for Heterogenous Assembloids Patterning |
| title_full | A Multifunctional Acoustic Tweezer for Heterogenous Assembloids Patterning |
| title_fullStr | A Multifunctional Acoustic Tweezer for Heterogenous Assembloids Patterning |
| title_full_unstemmed | A Multifunctional Acoustic Tweezer for Heterogenous Assembloids Patterning |
| title_short | A Multifunctional Acoustic Tweezer for Heterogenous Assembloids Patterning |
| title_sort | multifunctional acoustic tweezer for heterogenous assembloids patterning |
| topic | disease modeling heterogenous assembloids holographic acoustic tweezers stem cell engineering |
| url | https://doi.org/10.1002/sstr.202200288 |
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