Visualization of lipids in skeletal muscles by mass spectrometry imaging
Lipids are the major components of cells and, in addition to being involved in cell signaling, play a major role in the skeletal muscles. Lipids comprise a large number of molecular species with their different fatty acid compositions, and it is hard to visualize their spatial localization to identi...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Japanese Society of Physical Fitness and Sports Medicine
2017-07-01
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| Series: | Journal of Physical Fitness and Sports Medicine |
| Subjects: | |
| Online Access: | https://www.jstage.jst.go.jp/article/jpfsm/6/4/6_209/_pdf/-char/en |
| _version_ | 1818727764455325696 |
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| author | Naoko Goto-Inoue Tomohiko Sato Nobuharu L. Fujii |
| author_facet | Naoko Goto-Inoue Tomohiko Sato Nobuharu L. Fujii |
| author_sort | Naoko Goto-Inoue |
| collection | DOAJ |
| description | Lipids are the major components of cells and, in addition to being involved in cell signaling, play a major role in the skeletal muscles. Lipids comprise a large number of molecular species with their different fatty acid compositions, and it is hard to visualize their spatial localization to identify muscle-fiber-specific lipid dynamics. In this short review, we present a molecular imaging technology, matrix-assisted laser desorption/ionization mass spectrometry imaging, capable of imaging small metabolites including lipids. This technology has the potential to reveal the lipid dynamics that occur during muscle contraction and/or disease status. |
| first_indexed | 2024-12-17T22:19:17Z |
| format | Article |
| id | doaj.art-925475746f36434fb4368dc78ac6f3ea |
| institution | Directory Open Access Journal |
| issn | 2186-8131 2186-8123 |
| language | English |
| last_indexed | 2024-12-17T22:19:17Z |
| publishDate | 2017-07-01 |
| publisher | Japanese Society of Physical Fitness and Sports Medicine |
| record_format | Article |
| series | Journal of Physical Fitness and Sports Medicine |
| spelling | doaj.art-925475746f36434fb4368dc78ac6f3ea2022-12-21T21:30:30ZengJapanese Society of Physical Fitness and Sports MedicineJournal of Physical Fitness and Sports Medicine2186-81312186-81232017-07-016420921310.7600/jpfsm.6.209jpfsmVisualization of lipids in skeletal muscles by mass spectrometry imagingNaoko Goto-Inoue0Tomohiko Sato1Nobuharu L. Fujii2College of Bioresource Sciences, Nihon UniversityCollege of Bioresource Sciences, Nihon UniversityDepartment of Health Promotion Sciences, Graduate School of Human Health Sciences, Tokyo Metropolitan UniversityLipids are the major components of cells and, in addition to being involved in cell signaling, play a major role in the skeletal muscles. Lipids comprise a large number of molecular species with their different fatty acid compositions, and it is hard to visualize their spatial localization to identify muscle-fiber-specific lipid dynamics. In this short review, we present a molecular imaging technology, matrix-assisted laser desorption/ionization mass spectrometry imaging, capable of imaging small metabolites including lipids. This technology has the potential to reveal the lipid dynamics that occur during muscle contraction and/or disease status.https://www.jstage.jst.go.jp/article/jpfsm/6/4/6_209/_pdf/-char/enlipidmass spectrometry imagingtrainingskeletal muscle |
| spellingShingle | Naoko Goto-Inoue Tomohiko Sato Nobuharu L. Fujii Visualization of lipids in skeletal muscles by mass spectrometry imaging Journal of Physical Fitness and Sports Medicine lipid mass spectrometry imaging training skeletal muscle |
| title | Visualization of lipids in skeletal muscles by mass spectrometry imaging |
| title_full | Visualization of lipids in skeletal muscles by mass spectrometry imaging |
| title_fullStr | Visualization of lipids in skeletal muscles by mass spectrometry imaging |
| title_full_unstemmed | Visualization of lipids in skeletal muscles by mass spectrometry imaging |
| title_short | Visualization of lipids in skeletal muscles by mass spectrometry imaging |
| title_sort | visualization of lipids in skeletal muscles by mass spectrometry imaging |
| topic | lipid mass spectrometry imaging training skeletal muscle |
| url | https://www.jstage.jst.go.jp/article/jpfsm/6/4/6_209/_pdf/-char/en |
| work_keys_str_mv | AT naokogotoinoue visualizationoflipidsinskeletalmusclesbymassspectrometryimaging AT tomohikosato visualizationoflipidsinskeletalmusclesbymassspectrometryimaging AT nobuharulfujii visualizationoflipidsinskeletalmusclesbymassspectrometryimaging |