Prediction of protein aggregation on key proteins involved in ischemic stroke
Stroke is a genetic condition comprising multiple subtypes and arising from both genic and other multi factors. Genetic basis of stroke is well established through several studies. Advances in integrating sequencing methods and Genome-wide association studies have shown that genetics of stroke is ma...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2023-02-01
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| Series: | Journal of King Saud University: Science |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1018364722006553 |
| _version_ | 1797952859727200256 |
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| author | Rajendran Vijayakumar Palanisamy Manikandan Faiz Alfaiz Mohammad Saleh Al Aboodi Suresh Mickymaray Moorthy Kannaiyan Balaji Bhanoth Alaguraj Veluchamy |
| author_facet | Rajendran Vijayakumar Palanisamy Manikandan Faiz Alfaiz Mohammad Saleh Al Aboodi Suresh Mickymaray Moorthy Kannaiyan Balaji Bhanoth Alaguraj Veluchamy |
| author_sort | Rajendran Vijayakumar |
| collection | DOAJ |
| description | Stroke is a genetic condition comprising multiple subtypes and arising from both genic and other multi factors. Genetic basis of stroke is well established through several studies. Advances in integrating sequencing methods and Genome-wide association studies have shown that genetics of stroke is manifested in several genic disorders. Many of the neurodegenerative disorders show aggravated protein aggregation through amyloid formation. Through the protein aggregation prediction, we observed a higher protein disorder in 46 stroke-associated proteins. Also, we observed a large number of aggregation residues distributed as a pattern in multiple regions of these candidate proteins. Overall, we present a study showing that there is a possible interrelationship between protein aggregation and stroke. |
| first_indexed | 2024-04-10T22:52:43Z |
| format | Article |
| id | doaj.art-9254a7945e4c4649ab8b77df94d1aaec |
| institution | Directory Open Access Journal |
| issn | 1018-3647 |
| language | English |
| last_indexed | 2024-04-10T22:52:43Z |
| publishDate | 2023-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of King Saud University: Science |
| spelling | doaj.art-9254a7945e4c4649ab8b77df94d1aaec2023-01-15T04:21:16ZengElsevierJournal of King Saud University: Science1018-36472023-02-01352102474Prediction of protein aggregation on key proteins involved in ischemic strokeRajendran Vijayakumar0Palanisamy Manikandan1Faiz Alfaiz2Mohammad Saleh Al Aboodi3Suresh Mickymaray4Moorthy Kannaiyan5Balaji Bhanoth6Alaguraj Veluchamy7Department of Biology, College of Science in Zulfi, Majmaah University, Majmaah 11952, Saudi ArabiaDepartment of Medical Laboratory Sciences, College of Applied Medical Sciences, Majmaah University, Majmaah 11952, Saudi Arabia; Greenlink Analytical and Research Laboratory India Private Limited, Coimbatore 641 014, IndiaDepartment of Biology, College of Science in Zulfi, Majmaah University, Majmaah 11952, Saudi ArabiaDepartment of Biology, College of Science in Zulfi, Majmaah University, Majmaah 11952, Saudi ArabiaDepartment of Biology, College of Science in Zulfi, Majmaah University, Majmaah 11952, Saudi ArabiaDepartment of Medical Laboratory Science, School of Pharmacy and Medical Laboratory Science, Institute of Health, Bule Hora University, Post Box Number – 144, EthiopiaDepartment of Infectious Diseases, St. Jude Children's Research Hospital, Danny Thomas Place, Memphis 38105, TN, United States of AmericaBiological and Environmental Science and Engineering Division, King Abdullah University of Science and Technology, Thuwal, 23955, Saudi Arabia; Corresponding author.Stroke is a genetic condition comprising multiple subtypes and arising from both genic and other multi factors. Genetic basis of stroke is well established through several studies. Advances in integrating sequencing methods and Genome-wide association studies have shown that genetics of stroke is manifested in several genic disorders. Many of the neurodegenerative disorders show aggravated protein aggregation through amyloid formation. Through the protein aggregation prediction, we observed a higher protein disorder in 46 stroke-associated proteins. Also, we observed a large number of aggregation residues distributed as a pattern in multiple regions of these candidate proteins. Overall, we present a study showing that there is a possible interrelationship between protein aggregation and stroke.http://www.sciencedirect.com/science/article/pii/S1018364722006553Genetic disorderIschemic strokeProtein aggregationGene ontologyKEGG pathway |
| spellingShingle | Rajendran Vijayakumar Palanisamy Manikandan Faiz Alfaiz Mohammad Saleh Al Aboodi Suresh Mickymaray Moorthy Kannaiyan Balaji Bhanoth Alaguraj Veluchamy Prediction of protein aggregation on key proteins involved in ischemic stroke Journal of King Saud University: Science Genetic disorder Ischemic stroke Protein aggregation Gene ontology KEGG pathway |
| title | Prediction of protein aggregation on key proteins involved in ischemic stroke |
| title_full | Prediction of protein aggregation on key proteins involved in ischemic stroke |
| title_fullStr | Prediction of protein aggregation on key proteins involved in ischemic stroke |
| title_full_unstemmed | Prediction of protein aggregation on key proteins involved in ischemic stroke |
| title_short | Prediction of protein aggregation on key proteins involved in ischemic stroke |
| title_sort | prediction of protein aggregation on key proteins involved in ischemic stroke |
| topic | Genetic disorder Ischemic stroke Protein aggregation Gene ontology KEGG pathway |
| url | http://www.sciencedirect.com/science/article/pii/S1018364722006553 |
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