The fracture risk assessment tool (FRAX® score) in subclinical hyperthyroidism
Background/Aim. The Fracture Risk Assessment Tool (FRAX® score) is the 10-year estimated risk calculation tool for bone fracture that includes clinical data and hip bone mineral density measured by dual-energy x-ray absorptiometry (DXA). The aim of this cross-sectional study was to elucidat...
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| Format: | Article |
| Language: | English |
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Military Health Department, Ministry of Defance, Serbia
2015-01-01
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| Series: | Vojnosanitetski Pregled |
| Subjects: | |
| Online Access: | http://www.doiserbia.nb.rs/img/doi/0042-8450/2015/0042-84501506510P.pdf |
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| author | Polovina Snežana Micić Dragan Miljić Dragana Milić Nataša Micić Dušan Popović Vera |
| author_facet | Polovina Snežana Micić Dragan Miljić Dragana Milić Nataša Micić Dušan Popović Vera |
| author_sort | Polovina Snežana |
| collection | DOAJ |
| description | Background/Aim. The Fracture Risk Assessment Tool (FRAX® score) is the
10-year estimated risk calculation tool for bone fracture that includes
clinical data and hip bone mineral density measured by dual-energy x-ray
absorptiometry (DXA). The aim of this cross-sectional study was to elucidate
the ability of the FRAX® score in discriminating between bone fracture
positive and negative pre- and post-menopausal women with subclinical
hyperthyroidism. Methods. The bone mineral density (by DXA), thyroid
stimulating hormone (TSH) level, free thyroxine (fT4) level, thyroid
peroxidase antibodies (TPOAb) titre, osteocalcin and beta-cross-laps were
measured in 27 pre- and post-menopausal women with newly discovered
subclinical hyperthyroidism [age 58.85 ± 7.83 years, body mass index (BMI)
27.89 ± 3.46 kg/m2, menopause onset in 46.88 ± 10.21 years] and 51 matched
euthyroid controls (age 59.69 ± 5.72 years, BMI 27.68 ± 4.66 kg/m2, menopause
onset in 48.53 ± 4.58 years). The etiology of subclinical hyperthyroisims was
autoimmune thyroid disease or toxic goiter. FRAX® score calculation was
performed in both groups. Results. In the group with subclinical
hyperthyroidism the main FRAX® score was significantly higher than in the
controls (6.50 ± 1.58 vs 4.35 ± 1.56 respectively; p = 0.015). The FRAX®
score for hip was also higher in the evaluated group than in the controls
(1.33 ± 3.92 vs 0.50 ± 0.46 respectively; p = 0.022). There was no
correlations between low TSH and fracture risk (p > 0.05). The ability of
the FRAX® score in discriminating between bone fracture positive and negative
pre- and postmenopausal female subjects (p < 0.001) is presented by the area
under the curve (AUC) plotted via ROC analysis. The determined FRAX score
cut-off value by this analysis was 6%, with estimated sensitivity and
specificity of 95% and 75.9%, respectively. Conclusion. Pre- and
postmenopausal women with subclinical hyperthyroidism have higher FRAX®
scores and thus greater risk for low-trauma hip fracture than euthyroid
premenopausal women. Our results point to the use of FRAX® calculator in
monitoring pre- and postmenopausal women with subclinical hyperthyroidism to
detect subjects with high fracture risk in order to prevent further
fractures. |
| first_indexed | 2024-04-13T22:42:00Z |
| format | Article |
| id | doaj.art-9254b0935b934e10811948c3bad2e6ef |
| institution | Directory Open Access Journal |
| issn | 0042-8450 |
| language | English |
| last_indexed | 2024-04-13T22:42:00Z |
| publishDate | 2015-01-01 |
| publisher | Military Health Department, Ministry of Defance, Serbia |
| record_format | Article |
| series | Vojnosanitetski Pregled |
| spelling | doaj.art-9254b0935b934e10811948c3bad2e6ef2022-12-22T02:26:35ZengMilitary Health Department, Ministry of Defance, SerbiaVojnosanitetski Pregled0042-84502015-01-0172651051610.2298/VSP1506510P0042-84501506510PThe fracture risk assessment tool (FRAX® score) in subclinical hyperthyroidismPolovina Snežana0Micić Dragan1Miljić Dragana2Milić Nataša3Micić Dušan4Popović Vera5Clinical Center of Serbia, Clinic for Endocrinology, Diabetes and Diseases of Metabolism, BelgradeClinical Center of Serbia, Clinic for Endocrinology, Diabetes and Diseases of Metabolism, Belgrade + Faculty of Medicine, BelgradeClinical Center of Serbia, Clinic for Endocrinology, Diabetes and Diseases of Metabolism, BelgradeFaculty of Medicine, Belgrade + Faculty of Medicine, Institute for Medical Statistics and Informatics, BelgradeClinical Center of Serbia, Emergency Center, BelgradeClinical Center of Serbia, Clinic for Endocrinology, Diabetes and Diseases of Metabolism, Belgrade + †Faculty of Medicine, BelgradeBackground/Aim. The Fracture Risk Assessment Tool (FRAX® score) is the 10-year estimated risk calculation tool for bone fracture that includes clinical data and hip bone mineral density measured by dual-energy x-ray absorptiometry (DXA). The aim of this cross-sectional study was to elucidate the ability of the FRAX® score in discriminating between bone fracture positive and negative pre- and post-menopausal women with subclinical hyperthyroidism. Methods. The bone mineral density (by DXA), thyroid stimulating hormone (TSH) level, free thyroxine (fT4) level, thyroid peroxidase antibodies (TPOAb) titre, osteocalcin and beta-cross-laps were measured in 27 pre- and post-menopausal women with newly discovered subclinical hyperthyroidism [age 58.85 ± 7.83 years, body mass index (BMI) 27.89 ± 3.46 kg/m2, menopause onset in 46.88 ± 10.21 years] and 51 matched euthyroid controls (age 59.69 ± 5.72 years, BMI 27.68 ± 4.66 kg/m2, menopause onset in 48.53 ± 4.58 years). The etiology of subclinical hyperthyroisims was autoimmune thyroid disease or toxic goiter. FRAX® score calculation was performed in both groups. Results. In the group with subclinical hyperthyroidism the main FRAX® score was significantly higher than in the controls (6.50 ± 1.58 vs 4.35 ± 1.56 respectively; p = 0.015). The FRAX® score for hip was also higher in the evaluated group than in the controls (1.33 ± 3.92 vs 0.50 ± 0.46 respectively; p = 0.022). There was no correlations between low TSH and fracture risk (p > 0.05). The ability of the FRAX® score in discriminating between bone fracture positive and negative pre- and postmenopausal female subjects (p < 0.001) is presented by the area under the curve (AUC) plotted via ROC analysis. The determined FRAX score cut-off value by this analysis was 6%, with estimated sensitivity and specificity of 95% and 75.9%, respectively. Conclusion. Pre- and postmenopausal women with subclinical hyperthyroidism have higher FRAX® scores and thus greater risk for low-trauma hip fracture than euthyroid premenopausal women. Our results point to the use of FRAX® calculator in monitoring pre- and postmenopausal women with subclinical hyperthyroidism to detect subjects with high fracture risk in order to prevent further fractures.http://www.doiserbia.nb.rs/img/doi/0042-8450/2015/0042-84501506510P.pdfhip fracturesrisk assessmentquestionnairespostmenopausehyperthyroidism |
| spellingShingle | Polovina Snežana Micić Dragan Miljić Dragana Milić Nataša Micić Dušan Popović Vera The fracture risk assessment tool (FRAX® score) in subclinical hyperthyroidism Vojnosanitetski Pregled hip fractures risk assessment questionnaires postmenopause hyperthyroidism |
| title | The fracture risk assessment tool (FRAX® score) in subclinical hyperthyroidism |
| title_full | The fracture risk assessment tool (FRAX® score) in subclinical hyperthyroidism |
| title_fullStr | The fracture risk assessment tool (FRAX® score) in subclinical hyperthyroidism |
| title_full_unstemmed | The fracture risk assessment tool (FRAX® score) in subclinical hyperthyroidism |
| title_short | The fracture risk assessment tool (FRAX® score) in subclinical hyperthyroidism |
| title_sort | fracture risk assessment tool frax r score in subclinical hyperthyroidism |
| topic | hip fractures risk assessment questionnaires postmenopause hyperthyroidism |
| url | http://www.doiserbia.nb.rs/img/doi/0042-8450/2015/0042-84501506510P.pdf |
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