Efficacy and safety of combined piroxicam, dexamethasone, orphenadrine, and cyanocobalamin treatment in mandibular molar surgery
Third molar extraction is a common procedure frequently accompanied by moderate or severe pain, and involves sufficient numbers of patients to make studies relatively easy to perform. The aim of the present study was to determine the efficacy and safety of the therapeutic combination of 10 mg piroxi...
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| Format: | Article |
| Language: | English |
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Associação Brasileira de Divulgação Científica
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| Series: | Brazilian Journal of Medical and Biological Research |
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| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2006000900012&lng=en&tlng=en |
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| author | A.B. Barroso V. Lima G.C. Guzzo R.A. Moraes M.C. Vasconcellos M.M. Bezerra F.A.L. Viana R.C.R. Bezerra G.S.M. Santana F.A. Frota-Bezerra M.O. Moraes M.E.A. Moraes |
| author_facet | A.B. Barroso V. Lima G.C. Guzzo R.A. Moraes M.C. Vasconcellos M.M. Bezerra F.A.L. Viana R.C.R. Bezerra G.S.M. Santana F.A. Frota-Bezerra M.O. Moraes M.E.A. Moraes |
| author_sort | A.B. Barroso |
| collection | DOAJ |
| description | Third molar extraction is a common procedure frequently accompanied by moderate or severe pain, and involves sufficient numbers of patients to make studies relatively easy to perform. The aim of the present study was to determine the efficacy and safety of the therapeutic combination of 10 mg piroxicam, 1 mg dexamethasone, 35 mg orphenadrine citrate, and 2.5 mg cyanocobalamin (Rheumazin®) when compared with 20 mg piroxicam alone (Feldene®) in mandibular third molar surgery. Eighty patients scheduled for removal of the third molar were included in this randomized and double-blind study. They received (vo) Rheumazin or Feldene 30 min after tooth extraction and once daily for 4 consecutive days. Pain was determined by a visual analogue scale and by the need for escape analgesia (paracetamol). Facial swelling was evaluated with a measuring tape and adverse effects and patient satisfaction were recorded. There was no statistically significant difference in facial swelling between Rheumazin and Feldene (control group). Both drugs were equally effective in the control of pain, with Rheumazin displaying less adverse effects than Feldene. Therefore, Rheumazin appears to provide a better risk/benefit ratio in the mandibular molar surgery. Since the side effects resulting from nonsteroidal anti-inflammatory drug administration are a severe limitation to the routine use of these drugs in clinical practice, our results suggest that Rheumazin can be a good choice for third molar removal treatment. |
| first_indexed | 2024-12-11T00:01:22Z |
| format | Article |
| id | doaj.art-9254bb72470a41e38399916a7d9751ed |
| institution | Directory Open Access Journal |
| issn | 1414-431X |
| language | English |
| last_indexed | 2024-12-11T00:01:22Z |
| publisher | Associação Brasileira de Divulgação Científica |
| record_format | Article |
| series | Brazilian Journal of Medical and Biological Research |
| spelling | doaj.art-9254bb72470a41e38399916a7d9751ed2022-12-22T01:28:27ZengAssociação Brasileira de Divulgação CientíficaBrazilian Journal of Medical and Biological Research1414-431X3991241124710.1590/S0100-879X2006000900012S0100-879X2006000900012Efficacy and safety of combined piroxicam, dexamethasone, orphenadrine, and cyanocobalamin treatment in mandibular molar surgeryA.B. Barroso0V. Lima1G.C. Guzzo2R.A. Moraes3M.C. Vasconcellos4M.M. Bezerra5F.A.L. Viana6R.C.R. Bezerra7G.S.M. Santana8F.A. Frota-Bezerra9M.O. Moraes10M.E.A. Moraes11Universidade Federal do CearáUniversidade Federal do CearáUniversidade Federal do CearáUniversidade Federal do CearáUniversidade Federal do CearáUniversidade Federal do CearáUniversidade Federal do CearáUniversidade Federal do CearáUniversidade Federal do CearáUniversidade Federal do CearáUniversidade Federal do CearáUniversidade Federal do CearáThird molar extraction is a common procedure frequently accompanied by moderate or severe pain, and involves sufficient numbers of patients to make studies relatively easy to perform. The aim of the present study was to determine the efficacy and safety of the therapeutic combination of 10 mg piroxicam, 1 mg dexamethasone, 35 mg orphenadrine citrate, and 2.5 mg cyanocobalamin (Rheumazin®) when compared with 20 mg piroxicam alone (Feldene®) in mandibular third molar surgery. Eighty patients scheduled for removal of the third molar were included in this randomized and double-blind study. They received (vo) Rheumazin or Feldene 30 min after tooth extraction and once daily for 4 consecutive days. Pain was determined by a visual analogue scale and by the need for escape analgesia (paracetamol). Facial swelling was evaluated with a measuring tape and adverse effects and patient satisfaction were recorded. There was no statistically significant difference in facial swelling between Rheumazin and Feldene (control group). Both drugs were equally effective in the control of pain, with Rheumazin displaying less adverse effects than Feldene. Therefore, Rheumazin appears to provide a better risk/benefit ratio in the mandibular molar surgery. Since the side effects resulting from nonsteroidal anti-inflammatory drug administration are a severe limitation to the routine use of these drugs in clinical practice, our results suggest that Rheumazin can be a good choice for third molar removal treatment.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2006000900012&lng=en&tlng=enPiroxicamDexamethasoneOrphenadrineCyanocobalaminPainMandibular molar surgery |
| spellingShingle | A.B. Barroso V. Lima G.C. Guzzo R.A. Moraes M.C. Vasconcellos M.M. Bezerra F.A.L. Viana R.C.R. Bezerra G.S.M. Santana F.A. Frota-Bezerra M.O. Moraes M.E.A. Moraes Efficacy and safety of combined piroxicam, dexamethasone, orphenadrine, and cyanocobalamin treatment in mandibular molar surgery Brazilian Journal of Medical and Biological Research Piroxicam Dexamethasone Orphenadrine Cyanocobalamin Pain Mandibular molar surgery |
| title | Efficacy and safety of combined piroxicam, dexamethasone, orphenadrine, and cyanocobalamin treatment in mandibular molar surgery |
| title_full | Efficacy and safety of combined piroxicam, dexamethasone, orphenadrine, and cyanocobalamin treatment in mandibular molar surgery |
| title_fullStr | Efficacy and safety of combined piroxicam, dexamethasone, orphenadrine, and cyanocobalamin treatment in mandibular molar surgery |
| title_full_unstemmed | Efficacy and safety of combined piroxicam, dexamethasone, orphenadrine, and cyanocobalamin treatment in mandibular molar surgery |
| title_short | Efficacy and safety of combined piroxicam, dexamethasone, orphenadrine, and cyanocobalamin treatment in mandibular molar surgery |
| title_sort | efficacy and safety of combined piroxicam dexamethasone orphenadrine and cyanocobalamin treatment in mandibular molar surgery |
| topic | Piroxicam Dexamethasone Orphenadrine Cyanocobalamin Pain Mandibular molar surgery |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2006000900012&lng=en&tlng=en |
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