Organ-specificity of Estrogen Effects on the Induction of Immunocompetent Cells in the Chicken
Injection of immature hens with estrogen increases the population of antigen-presenting cells, T cells and Ig-containing cells in the ovary and oviduct. The aim of this study was to determine the organ-specificity of estrogen effects on the localization of immunocompetent cells in the chicken. Immat...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Japan Poultry Science Association
2001-01-01
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| Series: | The Journal of Poultry Science |
| Subjects: | |
| Online Access: | https://www.jstage.jst.go.jp/article/jpsa/38/1/38_1_41/_pdf/-char/en |
| Summary: | Injection of immature hens with estrogen increases the population of antigen-presenting cells, T cells and Ig-containing cells in the ovary and oviduct. The aim of this study was to determine the organ-specificity of estrogen effects on the localization of immunocompetent cells in the chicken. Immature hens were injected with or without diethylstilbestrol, which is an estrogenic compound, for 3 or 6 days and their vagina, ovary, liver, duodenum and lung were collected. Paraffin or frozen sections of them were immunostained for major histocompatibility complex (MHC) class II, CD3 (T cell antigen), Bu-1 (premature B cell antigen) and IgG, respectively. All four types of immunocompetent cells, namely MHC class II+, CD3+, Bu-1+ and IgG+ cells, were observed in the sections of each tissue. Treatment with diethylstilbestrol increased the population of these immunocompetent cells in the vagina, ovary and liver that are estrogen target organs, but not in the duodenum and lung. We suggest that estrogen increases immunocompetent cells in an organ-specific manner in the chicken. |
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| ISSN: | 1346-7395 1349-0486 |