Association of <it>MUTYH Gln324His </it>and <it>APEX1 Asp148Glu </it>with colorectal cancer and smoking in a Japanese population
<p>Abstract</p> <p>Background</p> <p>Genetic polymorphisms of DNA repair enzymes may lead to genetic instability and colorectal cancer carcinogenesis. Our objective was to measure the interactions between polymorphisms of repair genes and tobacco smoking in colorectal c...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
BMC
2008-09-01
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| Series: | Journal of Experimental & Clinical Cancer Research |
| Online Access: | http://www.jeccr.com/content/27/1/49 |
| _version_ | 1811260871796588544 |
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| author | Tabuchi Yoshiki Tsutou Akimitsu Inoue Natsuko Osawa Yasunori Miyaishi Aiko Yoshida Kana Osawa Kayo Kasahara Mayumi Tanaka Kenichi Yamamoto Masahiro Shimada Etsuji Takahashi Juro |
| author_facet | Tabuchi Yoshiki Tsutou Akimitsu Inoue Natsuko Osawa Yasunori Miyaishi Aiko Yoshida Kana Osawa Kayo Kasahara Mayumi Tanaka Kenichi Yamamoto Masahiro Shimada Etsuji Takahashi Juro |
| author_sort | Tabuchi Yoshiki |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Background</p> <p>Genetic polymorphisms of DNA repair enzymes may lead to genetic instability and colorectal cancer carcinogenesis. Our objective was to measure the interactions between polymorphisms of repair genes and tobacco smoking in colorectal cancer.</p> <p>Methods</p> <p>The case-control study involved sixty-eight colorectal cancer patients and 121 non-cancer controls divided into non-smokers and smokers according to pack-years of smoking. The genetic polymorphisms of DNA repair enzymes,<it>OGG1 Ser326Cys</it>, <it>MUTYH Gln324His</it>, <it>APEX1 Asp148Glu </it>and <it>XRCC1 Arg399Gln</it>, were examined using PCR-RFLP.</p> <p>Results</p> <p>The <it>MUTYH Gln324His </it>showed strong significant associations with a risk of colorectal cancer (crude odds ratio [OR] 3.30, 95% confidence interval [95%CI] 1.44–7.60, p = 0.005; adjusted OR3.53, 95%CI 1.44–8.70, p = 0.006). The ORs for the <it>APEX1 Asp148Glu </it>were statistically significant (crude OR 2.69, 95%CI 1.45–4.99, p = 0.002; adjusted OR 2.33, 95%CI 1.21–4.48, p = 0.011). The ORs for the <it>MUTYH Gln324His </it>and the <it>APEX1 Asp148Glu </it>were statistically significant for colon cancer (adjusted OR 3.95, 95%CI 1.28–12.20, p = 0.017 for <it>MUTYH Gln324His </it>; adjusted OR 3.04, 95%CI 1.38–6.71, p = 0.006 for <it>APEX1 Asp148Glu</it>). The joint effect of tobacco exposure and the <it>MUTYH Gln324His </it>showed a significant association with colorectal cancer risk in non-smokers (adjusted OR 4.08, 95%CI 1.22–13.58, p = 0.022) and the <it>APEX1 Asp148Glu </it>was significantly increased in smokers (adjusted OR 5.02, 95%CI 1.80–13.99, p = 0.002). However, the distributions of <it>OGG1 Ser326Cys </it>and <it>XRCC1 Arg399Gln </it>were not associated with a colorectal cancer risk.</p> <p>Conclusion</p> <p>Our findings suggest that the <it>MUTYH Gln324His </it>and the <it>APEX1 Asp148Glu </it>constitutes an increased risk of colorectal cancer, especially colon cancer. The <it>MUTYH Gln324His </it>is strongly associated with colorectal cancer susceptibility in never smoking history, whereas the <it>APEX1 Asp148Glu </it>genotype constitutes an increased risk of colorectal cancer when accompanied by smoking exposure.</p> |
| first_indexed | 2024-04-12T18:54:10Z |
| format | Article |
| id | doaj.art-925520903709491097c8c774396dd395 |
| institution | Directory Open Access Journal |
| issn | 1756-9966 |
| language | English |
| last_indexed | 2024-04-12T18:54:10Z |
| publishDate | 2008-09-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Experimental & Clinical Cancer Research |
| spelling | doaj.art-925520903709491097c8c774396dd3952022-12-22T03:20:23ZengBMCJournal of Experimental & Clinical Cancer Research1756-99662008-09-012714910.1186/1756-9966-27-49Association of <it>MUTYH Gln324His </it>and <it>APEX1 Asp148Glu </it>with colorectal cancer and smoking in a Japanese populationTabuchi YoshikiTsutou AkimitsuInoue NatsukoOsawa YasunoriMiyaishi AikoYoshida KanaOsawa KayoKasahara MayumiTanaka KenichiYamamoto MasahiroShimada EtsujiTakahashi Juro<p>Abstract</p> <p>Background</p> <p>Genetic polymorphisms of DNA repair enzymes may lead to genetic instability and colorectal cancer carcinogenesis. Our objective was to measure the interactions between polymorphisms of repair genes and tobacco smoking in colorectal cancer.</p> <p>Methods</p> <p>The case-control study involved sixty-eight colorectal cancer patients and 121 non-cancer controls divided into non-smokers and smokers according to pack-years of smoking. The genetic polymorphisms of DNA repair enzymes,<it>OGG1 Ser326Cys</it>, <it>MUTYH Gln324His</it>, <it>APEX1 Asp148Glu </it>and <it>XRCC1 Arg399Gln</it>, were examined using PCR-RFLP.</p> <p>Results</p> <p>The <it>MUTYH Gln324His </it>showed strong significant associations with a risk of colorectal cancer (crude odds ratio [OR] 3.30, 95% confidence interval [95%CI] 1.44–7.60, p = 0.005; adjusted OR3.53, 95%CI 1.44–8.70, p = 0.006). The ORs for the <it>APEX1 Asp148Glu </it>were statistically significant (crude OR 2.69, 95%CI 1.45–4.99, p = 0.002; adjusted OR 2.33, 95%CI 1.21–4.48, p = 0.011). The ORs for the <it>MUTYH Gln324His </it>and the <it>APEX1 Asp148Glu </it>were statistically significant for colon cancer (adjusted OR 3.95, 95%CI 1.28–12.20, p = 0.017 for <it>MUTYH Gln324His </it>; adjusted OR 3.04, 95%CI 1.38–6.71, p = 0.006 for <it>APEX1 Asp148Glu</it>). The joint effect of tobacco exposure and the <it>MUTYH Gln324His </it>showed a significant association with colorectal cancer risk in non-smokers (adjusted OR 4.08, 95%CI 1.22–13.58, p = 0.022) and the <it>APEX1 Asp148Glu </it>was significantly increased in smokers (adjusted OR 5.02, 95%CI 1.80–13.99, p = 0.002). However, the distributions of <it>OGG1 Ser326Cys </it>and <it>XRCC1 Arg399Gln </it>were not associated with a colorectal cancer risk.</p> <p>Conclusion</p> <p>Our findings suggest that the <it>MUTYH Gln324His </it>and the <it>APEX1 Asp148Glu </it>constitutes an increased risk of colorectal cancer, especially colon cancer. The <it>MUTYH Gln324His </it>is strongly associated with colorectal cancer susceptibility in never smoking history, whereas the <it>APEX1 Asp148Glu </it>genotype constitutes an increased risk of colorectal cancer when accompanied by smoking exposure.</p>http://www.jeccr.com/content/27/1/49 |
| spellingShingle | Tabuchi Yoshiki Tsutou Akimitsu Inoue Natsuko Osawa Yasunori Miyaishi Aiko Yoshida Kana Osawa Kayo Kasahara Mayumi Tanaka Kenichi Yamamoto Masahiro Shimada Etsuji Takahashi Juro Association of <it>MUTYH Gln324His </it>and <it>APEX1 Asp148Glu </it>with colorectal cancer and smoking in a Japanese population Journal of Experimental & Clinical Cancer Research |
| title | Association of <it>MUTYH Gln324His </it>and <it>APEX1 Asp148Glu </it>with colorectal cancer and smoking in a Japanese population |
| title_full | Association of <it>MUTYH Gln324His </it>and <it>APEX1 Asp148Glu </it>with colorectal cancer and smoking in a Japanese population |
| title_fullStr | Association of <it>MUTYH Gln324His </it>and <it>APEX1 Asp148Glu </it>with colorectal cancer and smoking in a Japanese population |
| title_full_unstemmed | Association of <it>MUTYH Gln324His </it>and <it>APEX1 Asp148Glu </it>with colorectal cancer and smoking in a Japanese population |
| title_short | Association of <it>MUTYH Gln324His </it>and <it>APEX1 Asp148Glu </it>with colorectal cancer and smoking in a Japanese population |
| title_sort | association of it mutyh gln324his it and it apex1 asp148glu it with colorectal cancer and smoking in a japanese population |
| url | http://www.jeccr.com/content/27/1/49 |
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