Neurodegenerative Proteinopathies Induced by Environmental Pollutants: Heat Shock Proteins and Proteasome as Promising Therapeutic Tools
Environmental pollutants’ (EPs) amount and diversity have increased in recent years due to anthropogenic activity. Several neurodegenerative diseases (NDs) are theorized to be related to EPs, as their incidence has increased in a similar way to human EPs exposure and they reproduce the main ND hallm...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-07-01
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| Series: | Pharmaceutics |
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| Online Access: | https://www.mdpi.com/1999-4923/15/8/2048 |
| _version_ | 1797583496407941120 |
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| author | Paula Moyano Emma Sola María Victoria Naval Lucia Guerra-Menéndez Maria De la Cabeza Fernández Javier del Pino |
| author_facet | Paula Moyano Emma Sola María Victoria Naval Lucia Guerra-Menéndez Maria De la Cabeza Fernández Javier del Pino |
| author_sort | Paula Moyano |
| collection | DOAJ |
| description | Environmental pollutants’ (EPs) amount and diversity have increased in recent years due to anthropogenic activity. Several neurodegenerative diseases (NDs) are theorized to be related to EPs, as their incidence has increased in a similar way to human EPs exposure and they reproduce the main ND hallmarks. EPs induce several neurotoxic effects, including accumulation and gradual deposition of misfolded toxic proteins, producing neuronal malfunction and cell death. Cells possess different mechanisms to eliminate these toxic proteins, including heat shock proteins (HSPs) and the proteasome system. The accumulation and deleterious effects of toxic proteins are induced through HSPs and disruption of proteasome proteins’ homeostatic function by exposure to EPs. A therapeutic approach has been proposed to reduce accumulation of toxic proteins through treatment with recombinant HSPs/proteasome or the use of compounds that increase their expression or activity. Our aim is to review the current literature on NDs related to EP exposure and their relationship with the disruption of the proteasome system and HSPs, as well as to discuss the toxic effects of dysfunction of HSPs and proteasome and the contradictory effects described in the literature. Lastly, we cover the therapeutic use of developed drugs and recombinant proteasome/HSPs to eliminate toxic proteins and prevent/treat EP-induced neurodegeneration. |
| first_indexed | 2024-03-10T23:39:44Z |
| format | Article |
| id | doaj.art-9258bda66a33444aba27b492b21b9542 |
| institution | Directory Open Access Journal |
| issn | 1999-4923 |
| language | English |
| last_indexed | 2024-03-10T23:39:44Z |
| publishDate | 2023-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceutics |
| spelling | doaj.art-9258bda66a33444aba27b492b21b95422023-11-19T02:35:56ZengMDPI AGPharmaceutics1999-49232023-07-01158204810.3390/pharmaceutics15082048Neurodegenerative Proteinopathies Induced by Environmental Pollutants: Heat Shock Proteins and Proteasome as Promising Therapeutic ToolsPaula Moyano0Emma Sola1María Victoria Naval2Lucia Guerra-Menéndez3Maria De la Cabeza Fernández4Javier del Pino5Department of Pharmacology and Toxicology, Veterinary School, Complutense University of Madrid, 28040 Madrid, SpainDepartment of Pharmacology and Toxicology, Veterinary School, Complutense University of Madrid, 28040 Madrid, SpainDepartment of Pharmacology, Pharmacognosy and Bothanic, Pharmacy School, Complutense University of Madrid, 28041 Madrid, SpainDepartment of Physiology, Medicine School, San Pablo CEU University, 28003 Madrid, SpainDepartment of Chemistry and Pharmaceutical Sciences, Pharmacy School, Complutense University of Madrid, 28041 Madrid, SpainDepartment of Pharmacology and Toxicology, Veterinary School, Complutense University of Madrid, 28040 Madrid, SpainEnvironmental pollutants’ (EPs) amount and diversity have increased in recent years due to anthropogenic activity. Several neurodegenerative diseases (NDs) are theorized to be related to EPs, as their incidence has increased in a similar way to human EPs exposure and they reproduce the main ND hallmarks. EPs induce several neurotoxic effects, including accumulation and gradual deposition of misfolded toxic proteins, producing neuronal malfunction and cell death. Cells possess different mechanisms to eliminate these toxic proteins, including heat shock proteins (HSPs) and the proteasome system. The accumulation and deleterious effects of toxic proteins are induced through HSPs and disruption of proteasome proteins’ homeostatic function by exposure to EPs. A therapeutic approach has been proposed to reduce accumulation of toxic proteins through treatment with recombinant HSPs/proteasome or the use of compounds that increase their expression or activity. Our aim is to review the current literature on NDs related to EP exposure and their relationship with the disruption of the proteasome system and HSPs, as well as to discuss the toxic effects of dysfunction of HSPs and proteasome and the contradictory effects described in the literature. Lastly, we cover the therapeutic use of developed drugs and recombinant proteasome/HSPs to eliminate toxic proteins and prevent/treat EP-induced neurodegeneration.https://www.mdpi.com/1999-4923/15/8/2048environmental pollutantsheat shock proteinsproteasomeproteinopathiesneurodegenerative diseases |
| spellingShingle | Paula Moyano Emma Sola María Victoria Naval Lucia Guerra-Menéndez Maria De la Cabeza Fernández Javier del Pino Neurodegenerative Proteinopathies Induced by Environmental Pollutants: Heat Shock Proteins and Proteasome as Promising Therapeutic Tools Pharmaceutics environmental pollutants heat shock proteins proteasome proteinopathies neurodegenerative diseases |
| title | Neurodegenerative Proteinopathies Induced by Environmental Pollutants: Heat Shock Proteins and Proteasome as Promising Therapeutic Tools |
| title_full | Neurodegenerative Proteinopathies Induced by Environmental Pollutants: Heat Shock Proteins and Proteasome as Promising Therapeutic Tools |
| title_fullStr | Neurodegenerative Proteinopathies Induced by Environmental Pollutants: Heat Shock Proteins and Proteasome as Promising Therapeutic Tools |
| title_full_unstemmed | Neurodegenerative Proteinopathies Induced by Environmental Pollutants: Heat Shock Proteins and Proteasome as Promising Therapeutic Tools |
| title_short | Neurodegenerative Proteinopathies Induced by Environmental Pollutants: Heat Shock Proteins and Proteasome as Promising Therapeutic Tools |
| title_sort | neurodegenerative proteinopathies induced by environmental pollutants heat shock proteins and proteasome as promising therapeutic tools |
| topic | environmental pollutants heat shock proteins proteasome proteinopathies neurodegenerative diseases |
| url | https://www.mdpi.com/1999-4923/15/8/2048 |
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