Disruption of grin2B, an ASD-associated gene, produces social deficits in zebrafish

Disruption of grin2B, an ASD-associated gene, produces social deficits in zebrafish

Abstract Background Autism spectrum disorder (ASD), like many neurodevelopmental disorders, has complex and varied etiologies. Advances in genome sequencing have identified multiple candidate genes associated with ASD, including dozens of missense and nonsense mutations in the NMDAR subunit GluN2B,...

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Bibliographic Details
Main Authors: Josiah D. Zoodsma, Emma J. Keegan, Gabrielle R. Moody, Ashwin A. Bhandiwad, Amalia J. Napoli, Harold A. Burgess, Lonnie P. Wollmuth, Howard I. Sirotkin
Format: Article
Language:English
Published: BMC 2022-09-01
Series:Molecular Autism
Subjects:
NMDA receptors
GluN2B
Autism spectrum disorders
Social behaviors
Online Access:https://doi.org/10.1186/s13229-022-00516-3

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