Effect of Thyroid Hormone Levels on Glycemic Control: The Indian Context
Objective: Diabetes mellitus (DM) is known as the silent pandemic. It is hypothesized that other endocrine systems are affected by the metabolic changes occurring due to DM. We aimed to investigate the correlation of thyroid hormones with glycaemic and lipid parameters. Materials and Methods: 81 dia...
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| Format: | Article |
| Language: | English |
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Shahid Sadoughi University of Medical Sciences
2022-09-01
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| Series: | Iranian Journal of Diabetes and Obesity |
| Subjects: | |
| Online Access: | http://ijdo.ssu.ac.ir/article-1-725-en.html |
| _version_ | 1828235731054624768 |
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| author | Vatsal Navin Jain Swati Ghanghurde Sherwin Rajesh Carvalho Shivani Sachin Nirgudkar Mohit Vijay Rojekar |
| author_facet | Vatsal Navin Jain Swati Ghanghurde Sherwin Rajesh Carvalho Shivani Sachin Nirgudkar Mohit Vijay Rojekar |
| author_sort | Vatsal Navin Jain |
| collection | DOAJ |
| description | Objective: Diabetes mellitus (DM) is known as the silent pandemic. It is hypothesized that other endocrine systems are affected by the metabolic changes occurring due to DM. We aimed to investigate the correlation of thyroid hormones with glycaemic and lipid parameters.
Materials and Methods: 81 diabetic patients and 81 non-diabetic age and sex-matched healthy volunteers participated in the study. Their blood samples were analysed for fasting blood glucose (FBG), glycosylated haemoglobin (HbA1C), total tri-iodothyronine (T3), total thyroxine (T4), free T3 (FT3), free T4 (FT4), thyroid-stimulating hormone (TSH), total cholesterol (CHOL), High-Density-Lipoprotein cholesterol (HDLC) and Low-Density-Lipoprotein cholesterol (LDLC). Data was analysed using appropriate statistical tests.
Results: Among the cases, 70.37% were euthyroid, while 24.7% had subclinical hypothyroidism, 2.47% had clinical hypothyroidism, 1.23% had subclinical and 1.23% had clinical hyperthyroidism. FBG, HbA1c and TSH (P< 0.05) were significantly higher in diabetics compared to controls. On the other hand, T3, FT3, FT4, and HDLC (P< 0.05) were significantly lower in diabetics compared to controls. A significant negative correlation (P< 0.05) was found when T3 and FT3 were compared against age, FBG and HbA1c. A significant positive correlation (P< 0.05) was found when T3 and FT3 were compared against HDLC, LDLC & CHOL.
Conclusion: Our statistics show that high-normal levels of T3 and FT3 are correlated with lower levels of FBG and HbA1c, hence improved glycaemic control. We recommend that thyroid profile of diabetic patients with poor control should be monitored regularly. Early detection of thyroid dysfunction and initiation of therapy for it, can improve the treatment outcome of hypoglycaemic drugs. |
| first_indexed | 2024-04-12T20:19:25Z |
| format | Article |
| id | doaj.art-925bd82242de4cc9ae6f7b4d76331988 |
| institution | Directory Open Access Journal |
| issn | 2008-6792 2345-2250 |
| language | English |
| last_indexed | 2024-04-12T20:19:25Z |
| publishDate | 2022-09-01 |
| publisher | Shahid Sadoughi University of Medical Sciences |
| record_format | Article |
| series | Iranian Journal of Diabetes and Obesity |
| spelling | doaj.art-925bd82242de4cc9ae6f7b4d763319882022-12-22T03:18:01ZengShahid Sadoughi University of Medical SciencesIranian Journal of Diabetes and Obesity2008-67922345-22502022-09-01143131137Effect of Thyroid Hormone Levels on Glycemic Control: The Indian ContextVatsal Navin Jain0Swati Ghanghurde1Sherwin Rajesh Carvalho2Shivani Sachin Nirgudkar3Mohit Vijay Rojekar4 MBBS student, Rajiv Gandhi Medical College, Kalwa, Thane, Maharashtra, India. 2Assistant Professor, Department of Pathology Rajiv Gandhi Medical College, Kalwa, Thane, Maharashtra, India. MBBS student, Rajiv Gandhi Medical College, Kalwa, Thane, Maharashtra, India. MBBS student, Rajiv Gandhi Medical College, Kalwa, Thane, Maharashtra, India. Professor & Head, Department of Biochemistry Rajiv Gandhi Medical College, Kalwa, Thane, Maharashtra, India. Objective: Diabetes mellitus (DM) is known as the silent pandemic. It is hypothesized that other endocrine systems are affected by the metabolic changes occurring due to DM. We aimed to investigate the correlation of thyroid hormones with glycaemic and lipid parameters. Materials and Methods: 81 diabetic patients and 81 non-diabetic age and sex-matched healthy volunteers participated in the study. Their blood samples were analysed for fasting blood glucose (FBG), glycosylated haemoglobin (HbA1C), total tri-iodothyronine (T3), total thyroxine (T4), free T3 (FT3), free T4 (FT4), thyroid-stimulating hormone (TSH), total cholesterol (CHOL), High-Density-Lipoprotein cholesterol (HDLC) and Low-Density-Lipoprotein cholesterol (LDLC). Data was analysed using appropriate statistical tests. Results: Among the cases, 70.37% were euthyroid, while 24.7% had subclinical hypothyroidism, 2.47% had clinical hypothyroidism, 1.23% had subclinical and 1.23% had clinical hyperthyroidism. FBG, HbA1c and TSH (P< 0.05) were significantly higher in diabetics compared to controls. On the other hand, T3, FT3, FT4, and HDLC (P< 0.05) were significantly lower in diabetics compared to controls. A significant negative correlation (P< 0.05) was found when T3 and FT3 were compared against age, FBG and HbA1c. A significant positive correlation (P< 0.05) was found when T3 and FT3 were compared against HDLC, LDLC & CHOL. Conclusion: Our statistics show that high-normal levels of T3 and FT3 are correlated with lower levels of FBG and HbA1c, hence improved glycaemic control. We recommend that thyroid profile of diabetic patients with poor control should be monitored regularly. Early detection of thyroid dysfunction and initiation of therapy for it, can improve the treatment outcome of hypoglycaemic drugs.http://ijdo.ssu.ac.ir/article-1-725-en.htmlthyroid hormoneshypothyroidismdiabetes mellitusglycated haemoglobin a |
| spellingShingle | Vatsal Navin Jain Swati Ghanghurde Sherwin Rajesh Carvalho Shivani Sachin Nirgudkar Mohit Vijay Rojekar Effect of Thyroid Hormone Levels on Glycemic Control: The Indian Context Iranian Journal of Diabetes and Obesity thyroid hormones hypothyroidism diabetes mellitus glycated haemoglobin a |
| title | Effect of Thyroid Hormone Levels on Glycemic Control: The Indian Context |
| title_full | Effect of Thyroid Hormone Levels on Glycemic Control: The Indian Context |
| title_fullStr | Effect of Thyroid Hormone Levels on Glycemic Control: The Indian Context |
| title_full_unstemmed | Effect of Thyroid Hormone Levels on Glycemic Control: The Indian Context |
| title_short | Effect of Thyroid Hormone Levels on Glycemic Control: The Indian Context |
| title_sort | effect of thyroid hormone levels on glycemic control the indian context |
| topic | thyroid hormones hypothyroidism diabetes mellitus glycated haemoglobin a |
| url | http://ijdo.ssu.ac.ir/article-1-725-en.html |
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