Spinal osteoarthritis is a risk of vertebral fractures in postmenopausal women
Abstract Recent studies have revealed that despite high bone mineral density (BMD), osteoarthritis (OA) is a risk factor for osteoporotic fractures. However, the relationship between spinal OA and vertebral fractures has not yet been fully investigated. This longitudinal analysis used a subset of on...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2024-02-01
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| Series: | Scientific Reports |
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| Online Access: | https://doi.org/10.1038/s41598-024-53994-1 |
| _version_ | 1797274732778749952 |
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| author | Tatsuhiko Kuroda Masataka Shiraki Mitsuru Saito Tomohiko Urano |
| author_facet | Tatsuhiko Kuroda Masataka Shiraki Mitsuru Saito Tomohiko Urano |
| author_sort | Tatsuhiko Kuroda |
| collection | DOAJ |
| description | Abstract Recent studies have revealed that despite high bone mineral density (BMD), osteoarthritis (OA) is a risk factor for osteoporotic fractures. However, the relationship between spinal OA and vertebral fractures has not yet been fully investigated. This longitudinal analysis used a subset of ongoing cohort study consist with Japanese postmenopausal women. The prevalence of spinal OA was determined using Kellgren–Lawrence grading method. The incidence of vertebral fractures were determined by semiquantitative analysis of spinal X-ray films. The relationship between the presence of spinal OA and incidence of vertebral fractures was evaluated using the Cox regression analysis. In total, 1480 women were followed up for 8.1 ± 6.4 years. Among them, 923 were diagnosed with spinal OA, and incident vertebral fractures were observed in 473 participants. After adjusting for confounding variables, the spinal OA (≥ grade 2) was a significant predictor of incident vertebral fractures (hazard ratio, 1.52; 95% confidence interval: 1.19–1.93, p = 0.001). Using ROC analysis, the thresholds of lumbar BMD for incident vertebral fractures were 0.952 g/cm2 for patients with spinal OA and 0.753 g/cm2 for patients without spinal OA. The presence of spinal OA is a risk factor for incident vertebral fractures despite high lumbar BMD. |
| first_indexed | 2024-03-07T15:02:28Z |
| format | Article |
| id | doaj.art-925cf52d5bbd488cbe7948d52e5a2540 |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-03-07T15:02:28Z |
| publishDate | 2024-02-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-925cf52d5bbd488cbe7948d52e5a25402024-03-05T19:03:50ZengNature PortfolioScientific Reports2045-23222024-02-011411810.1038/s41598-024-53994-1Spinal osteoarthritis is a risk of vertebral fractures in postmenopausal womenTatsuhiko Kuroda0Masataka Shiraki1Mitsuru Saito2Tomohiko Urano3Public Health Research FoundationResearch Institute and Practice for Involutional DiseasesDepartment of Orthopedic Surgery, Tokyo Jikei University, School of MedicineDepartment of Geriatric Medicine, International University of Health and Welfare School of MedicineAbstract Recent studies have revealed that despite high bone mineral density (BMD), osteoarthritis (OA) is a risk factor for osteoporotic fractures. However, the relationship between spinal OA and vertebral fractures has not yet been fully investigated. This longitudinal analysis used a subset of ongoing cohort study consist with Japanese postmenopausal women. The prevalence of spinal OA was determined using Kellgren–Lawrence grading method. The incidence of vertebral fractures were determined by semiquantitative analysis of spinal X-ray films. The relationship between the presence of spinal OA and incidence of vertebral fractures was evaluated using the Cox regression analysis. In total, 1480 women were followed up for 8.1 ± 6.4 years. Among them, 923 were diagnosed with spinal OA, and incident vertebral fractures were observed in 473 participants. After adjusting for confounding variables, the spinal OA (≥ grade 2) was a significant predictor of incident vertebral fractures (hazard ratio, 1.52; 95% confidence interval: 1.19–1.93, p = 0.001). Using ROC analysis, the thresholds of lumbar BMD for incident vertebral fractures were 0.952 g/cm2 for patients with spinal OA and 0.753 g/cm2 for patients without spinal OA. The presence of spinal OA is a risk factor for incident vertebral fractures despite high lumbar BMD.https://doi.org/10.1038/s41598-024-53994-1OsteoarthritisFracture riskBone mineral density |
| spellingShingle | Tatsuhiko Kuroda Masataka Shiraki Mitsuru Saito Tomohiko Urano Spinal osteoarthritis is a risk of vertebral fractures in postmenopausal women Scientific Reports Osteoarthritis Fracture risk Bone mineral density |
| title | Spinal osteoarthritis is a risk of vertebral fractures in postmenopausal women |
| title_full | Spinal osteoarthritis is a risk of vertebral fractures in postmenopausal women |
| title_fullStr | Spinal osteoarthritis is a risk of vertebral fractures in postmenopausal women |
| title_full_unstemmed | Spinal osteoarthritis is a risk of vertebral fractures in postmenopausal women |
| title_short | Spinal osteoarthritis is a risk of vertebral fractures in postmenopausal women |
| title_sort | spinal osteoarthritis is a risk of vertebral fractures in postmenopausal women |
| topic | Osteoarthritis Fracture risk Bone mineral density |
| url | https://doi.org/10.1038/s41598-024-53994-1 |
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