Designing an irreversible metabolic switch for scalable induction of microbial chemical production
A promising strategy to increase product synthesis from bacteria uses inducible systems to switch metabolism to production. Here, the authors use models to show how engineering positive feedback loops into the genetic circuitry creates a switch that requires only temporary induction with a cheap nut...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2021-06-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-021-23606-x |
| _version_ | 1819038950787907584 |
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| author | Ahmad A. Mannan Declan G. Bates |
| author_facet | Ahmad A. Mannan Declan G. Bates |
| author_sort | Ahmad A. Mannan |
| collection | DOAJ |
| description | A promising strategy to increase product synthesis from bacteria uses inducible systems to switch metabolism to production. Here, the authors use models to show how engineering positive feedback loops into the genetic circuitry creates a switch that requires only temporary induction with a cheap nutrient to switch metabolism irreversibly, and so drastically reduce inducer use and cost. |
| first_indexed | 2024-12-21T08:45:27Z |
| format | Article |
| id | doaj.art-925f3bab049a46a39d8569145e04adbe |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-21T08:45:27Z |
| publishDate | 2021-06-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-925f3bab049a46a39d8569145e04adbe2022-12-21T19:09:51ZengNature PortfolioNature Communications2041-17232021-06-0112111110.1038/s41467-021-23606-xDesigning an irreversible metabolic switch for scalable induction of microbial chemical productionAhmad A. Mannan0Declan G. Bates1Warwick Integrative Synthetic Biology Centre, School of Engineering, University of WarwickWarwick Integrative Synthetic Biology Centre, School of Engineering, University of WarwickA promising strategy to increase product synthesis from bacteria uses inducible systems to switch metabolism to production. Here, the authors use models to show how engineering positive feedback loops into the genetic circuitry creates a switch that requires only temporary induction with a cheap nutrient to switch metabolism irreversibly, and so drastically reduce inducer use and cost.https://doi.org/10.1038/s41467-021-23606-x |
| spellingShingle | Ahmad A. Mannan Declan G. Bates Designing an irreversible metabolic switch for scalable induction of microbial chemical production Nature Communications |
| title | Designing an irreversible metabolic switch for scalable induction of microbial chemical production |
| title_full | Designing an irreversible metabolic switch for scalable induction of microbial chemical production |
| title_fullStr | Designing an irreversible metabolic switch for scalable induction of microbial chemical production |
| title_full_unstemmed | Designing an irreversible metabolic switch for scalable induction of microbial chemical production |
| title_short | Designing an irreversible metabolic switch for scalable induction of microbial chemical production |
| title_sort | designing an irreversible metabolic switch for scalable induction of microbial chemical production |
| url | https://doi.org/10.1038/s41467-021-23606-x |
| work_keys_str_mv | AT ahmadamannan designinganirreversiblemetabolicswitchforscalableinductionofmicrobialchemicalproduction AT declangbates designinganirreversiblemetabolicswitchforscalableinductionofmicrobialchemicalproduction |