SET1/MLL family of proteins: functions beyond histone methylation
The SET1 family of enzymes are well known for their involvement in the histone 3 lysine 4 (H3K4) methylation, a conserved trait of euchromatin associated with transcriptional activation. These methyltransferases are distinct, and involved in various biological functions in the cell. Impairment in th...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2021-05-01
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| Series: | Epigenetics |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/15592294.2020.1809873 |
| _version_ | 1827811477912813568 |
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| author | Jeyapal Sugeedha Jyoti Gautam Shweta Tyagi |
| author_facet | Jeyapal Sugeedha Jyoti Gautam Shweta Tyagi |
| author_sort | Jeyapal Sugeedha |
| collection | DOAJ |
| description | The SET1 family of enzymes are well known for their involvement in the histone 3 lysine 4 (H3K4) methylation, a conserved trait of euchromatin associated with transcriptional activation. These methyltransferases are distinct, and involved in various biological functions in the cell. Impairment in the function of SET1 family members leads to a number of abnormalities such as skeletal and neurological defects, leukaemogenesis and even lethality. Tremendous progress has been made in understanding the unique biological roles and the mechanism of SET1 enzymes in context with H3K4 methylation/canonical functions. However, in recent years, several studies have indicated the novel role of SET1 family proteins, other than H3K4 methylation, which are equally important for cellular functions. In this review, we focus on these non-canonical function of SET1 family members. |
| first_indexed | 2024-03-11T23:05:40Z |
| format | Article |
| id | doaj.art-9260b4213e114a6a985ac8cebaf9122a |
| institution | Directory Open Access Journal |
| issn | 1559-2294 1559-2308 |
| language | English |
| last_indexed | 2024-03-11T23:05:40Z |
| publishDate | 2021-05-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Epigenetics |
| spelling | doaj.art-9260b4213e114a6a985ac8cebaf9122a2023-09-21T13:09:24ZengTaylor & Francis GroupEpigenetics1559-22941559-23082021-05-0116546948710.1080/15592294.2020.18098731809873SET1/MLL family of proteins: functions beyond histone methylationJeyapal Sugeedha0Jyoti Gautam1Shweta Tyagi2Centre for DNA Fingerprinting and Diagnostics (CDFD)Centre for DNA Fingerprinting and Diagnostics (CDFD)Centre for DNA Fingerprinting and Diagnostics (CDFD)The SET1 family of enzymes are well known for their involvement in the histone 3 lysine 4 (H3K4) methylation, a conserved trait of euchromatin associated with transcriptional activation. These methyltransferases are distinct, and involved in various biological functions in the cell. Impairment in the function of SET1 family members leads to a number of abnormalities such as skeletal and neurological defects, leukaemogenesis and even lethality. Tremendous progress has been made in understanding the unique biological roles and the mechanism of SET1 enzymes in context with H3K4 methylation/canonical functions. However, in recent years, several studies have indicated the novel role of SET1 family proteins, other than H3K4 methylation, which are equally important for cellular functions. In this review, we focus on these non-canonical function of SET1 family members.http://dx.doi.org/10.1080/15592294.2020.1809873mllsetd1ah3k4 histone methyltransferasenon-canonical functionscell cyclenon-histone protein substrates |
| spellingShingle | Jeyapal Sugeedha Jyoti Gautam Shweta Tyagi SET1/MLL family of proteins: functions beyond histone methylation Epigenetics mll setd1a h3k4 histone methyltransferase non-canonical functions cell cycle non-histone protein substrates |
| title | SET1/MLL family of proteins: functions beyond histone methylation |
| title_full | SET1/MLL family of proteins: functions beyond histone methylation |
| title_fullStr | SET1/MLL family of proteins: functions beyond histone methylation |
| title_full_unstemmed | SET1/MLL family of proteins: functions beyond histone methylation |
| title_short | SET1/MLL family of proteins: functions beyond histone methylation |
| title_sort | set1 mll family of proteins functions beyond histone methylation |
| topic | mll setd1a h3k4 histone methyltransferase non-canonical functions cell cycle non-histone protein substrates |
| url | http://dx.doi.org/10.1080/15592294.2020.1809873 |
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