MIR337-3p Enhances Mycobacterial Pathogenicity Involving TLR4/MYD88 and STAT3 Signals, Impairing VDR Antimicrobial Response and Fast-Acting Immunity

MIR337-3p Enhances Mycobacterial Pathogenicity Involving TLR4/MYD88 and STAT3 Signals, Impairing VDR Antimicrobial Response and Fast-Acting Immunity

Active form of vitamin D (VitD) enhances human innate immunity against Mycobacterium tuberculosis (Mtb) infection. Our previous studies showed that MIR337-3p was highly expressed in lymphocytes of tuberculosis (TB) patients. Here, we identified the mechanism of MIR337-3p in the regulation of fast-ac...

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Bibliographic Details
Main Authors: Shanshan Liang, Guixian Huang, Tian Wu, Ying Peng, Xi Liu, Xuejiao Ji, Wei Sha, Feifei Wang, Ling Shen, Hongbo Shen
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-11-01
Series:Frontiers in Immunology
Subjects:
Mycobacterium tuberculosis
miR337-3p
vitamin D3
TLR4
STAT3
CYP27B1
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.739219/full

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