Comparison of the <i>Opn-CreER</i> and <i>Ck19-CreER</i> Drivers in Bile Ducts of Normal and Injured Mouse Livers

Comparison of the <i>Opn-CreER</i> and <i>Ck19-CreER</i> Drivers in Bile Ducts of Normal and Injured Mouse Livers

Inducible cyclization recombinase (Cre) transgenic mouse strains are powerful tools for cell lineage tracing and tissue-specific knockout experiments. However, low efficiency or leaky expression can be important pitfalls. Here, we compared the efficiency and specificity of two commonly used cholangi...

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Bibliographic Details
Main Authors: Bram Lesaffer, Elisabeth Verboven, Leen Van Huffel, Iván M. Moya, Leo A. van Grunsven, Isabelle A. Leclercq, Frédéric P. Lemaigre, Georg Halder
Format: Article
Language:English
Published: MDPI AG 2019-04-01
Series:Cells
Subjects:
Cre
cholangiocytes
bile duct cells
knockout
mouse liver
lineage tracing
Opn
Ck19
Online Access:https://www.mdpi.com/2073-4409/8/4/380

Internet

https://www.mdpi.com/2073-4409/8/4/380

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