Diversity, Biosynthesis and Bioactivity of Aeruginosins, a Family of Cyanobacteria-Derived Nonribosomal Linear Tetrapeptides
Aeruginosins, a family of nonribosomal linear tetrapeptides discovered from cyanobacteria and sponges, exhibit in vitro inhibitory activity on various types of serine proteases. This family is characterized by the existence of the 2-carboxy-6-hydroxy-octahydroindole (Choi) moiety occupied at the cen...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-03-01
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| Series: | Marine Drugs |
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| Online Access: | https://www.mdpi.com/1660-3397/21/4/217 |
| _version_ | 1827744578515501056 |
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| author | Jiameng Liu Mengli Zhang Zhenkuai Huang Jiaqi Fang Zhongyuan Wang Chengxu Zhou Xiaoting Qiu |
| author_facet | Jiameng Liu Mengli Zhang Zhenkuai Huang Jiaqi Fang Zhongyuan Wang Chengxu Zhou Xiaoting Qiu |
| author_sort | Jiameng Liu |
| collection | DOAJ |
| description | Aeruginosins, a family of nonribosomal linear tetrapeptides discovered from cyanobacteria and sponges, exhibit in vitro inhibitory activity on various types of serine proteases. This family is characterized by the existence of the 2-carboxy-6-hydroxy-octahydroindole (Choi) moiety occupied at the central position of the tetrapeptide. Aeruginosins have attracted much attention due to their special structures and unique bioactivities. Although many studies on aeruginosins have been published, there has not yet been a comprehensive review that summarizes the diverse research ranging from biogenesis, structural characterization and biosynthesis to bioactivity. In this review, we provide an overview of the source, chemical structure as well as spectrum of bioactivities of aeruginosins. Furthermore, possible opportunities for future research and development of aeruginosins were discussed. |
| first_indexed | 2024-03-11T04:49:14Z |
| format | Article |
| id | doaj.art-9264bc13408c43b685f5b7824b297469 |
| institution | Directory Open Access Journal |
| issn | 1660-3397 |
| language | English |
| last_indexed | 2024-03-11T04:49:14Z |
| publishDate | 2023-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Marine Drugs |
| spelling | doaj.art-9264bc13408c43b685f5b7824b2974692023-11-17T20:10:08ZengMDPI AGMarine Drugs1660-33972023-03-0121421710.3390/md21040217Diversity, Biosynthesis and Bioactivity of Aeruginosins, a Family of Cyanobacteria-Derived Nonribosomal Linear TetrapeptidesJiameng Liu0Mengli Zhang1Zhenkuai Huang2Jiaqi Fang3Zhongyuan Wang4Chengxu Zhou5Xiaoting Qiu6Ministry of Education Key Laboratory of Applied Marine Biotechnology, Ningbo University, Ningbo 315800, ChinaMinistry of Education Key Laboratory of Applied Marine Biotechnology, Ningbo University, Ningbo 315800, ChinaMinistry of Education Key Laboratory of Applied Marine Biotechnology, Ningbo University, Ningbo 315800, ChinaMinistry of Education Key Laboratory of Applied Marine Biotechnology, Ningbo University, Ningbo 315800, ChinaMinistry of Education Key Laboratory of Applied Marine Biotechnology, Ningbo University, Ningbo 315800, ChinaMinistry of Education Key Laboratory of Applied Marine Biotechnology, Ningbo University, Ningbo 315800, ChinaMinistry of Education Key Laboratory of Applied Marine Biotechnology, Ningbo University, Ningbo 315800, ChinaAeruginosins, a family of nonribosomal linear tetrapeptides discovered from cyanobacteria and sponges, exhibit in vitro inhibitory activity on various types of serine proteases. This family is characterized by the existence of the 2-carboxy-6-hydroxy-octahydroindole (Choi) moiety occupied at the central position of the tetrapeptide. Aeruginosins have attracted much attention due to their special structures and unique bioactivities. Although many studies on aeruginosins have been published, there has not yet been a comprehensive review that summarizes the diverse research ranging from biogenesis, structural characterization and biosynthesis to bioactivity. In this review, we provide an overview of the source, chemical structure as well as spectrum of bioactivities of aeruginosins. Furthermore, possible opportunities for future research and development of aeruginosins were discussed.https://www.mdpi.com/1660-3397/21/4/217aeruginosinsChoibiogenesisstructural diversitynonribosomal polypeptide synthesisserine protease inhibitory activity |
| spellingShingle | Jiameng Liu Mengli Zhang Zhenkuai Huang Jiaqi Fang Zhongyuan Wang Chengxu Zhou Xiaoting Qiu Diversity, Biosynthesis and Bioactivity of Aeruginosins, a Family of Cyanobacteria-Derived Nonribosomal Linear Tetrapeptides Marine Drugs aeruginosins Choi biogenesis structural diversity nonribosomal polypeptide synthesis serine protease inhibitory activity |
| title | Diversity, Biosynthesis and Bioactivity of Aeruginosins, a Family of Cyanobacteria-Derived Nonribosomal Linear Tetrapeptides |
| title_full | Diversity, Biosynthesis and Bioactivity of Aeruginosins, a Family of Cyanobacteria-Derived Nonribosomal Linear Tetrapeptides |
| title_fullStr | Diversity, Biosynthesis and Bioactivity of Aeruginosins, a Family of Cyanobacteria-Derived Nonribosomal Linear Tetrapeptides |
| title_full_unstemmed | Diversity, Biosynthesis and Bioactivity of Aeruginosins, a Family of Cyanobacteria-Derived Nonribosomal Linear Tetrapeptides |
| title_short | Diversity, Biosynthesis and Bioactivity of Aeruginosins, a Family of Cyanobacteria-Derived Nonribosomal Linear Tetrapeptides |
| title_sort | diversity biosynthesis and bioactivity of aeruginosins a family of cyanobacteria derived nonribosomal linear tetrapeptides |
| topic | aeruginosins Choi biogenesis structural diversity nonribosomal polypeptide synthesis serine protease inhibitory activity |
| url | https://www.mdpi.com/1660-3397/21/4/217 |
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