Orexin induces the production of an endocannabinoid-derived lysophosphatidic acid eliciting hypothalamic synaptic loss in obesity

Orexin induces the production of an endocannabinoid-derived lysophosphatidic acid eliciting hypothalamic synaptic loss in obesity

Objective: Orexin-A (OX-A) is a neuropeptide produced selectively by neurons of the lateral hypothalamus. It exerts powerful control over brain function and physiology by regulating energy homeostasis and complex behaviors linked to arousal. Under conditions of chronic or acute brain leptin signalin...

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Bibliographic Details
Main Authors: Alba Clara Fernández-Rilo, Nicola Forte, Letizia Palomba, Lea Tunisi, Fabiana Piscitelli, Roberta Imperatore, Alfonso Di Costanzo, Vincenzo Di Marzo, Luigia Cristino
Format: Article
Language:English
Published: Elsevier 2023-06-01
Series:Molecular Metabolism
Subjects:
Hypothalamus
Obesity
α-MSH
Orexin/hypocretin
2-Arachidonoyl-glycerol
2-AG
Online Access:http://www.sciencedirect.com/science/article/pii/S2212877823000479

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http://www.sciencedirect.com/science/article/pii/S2212877823000479

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