A C-Terminally Truncated TDP-43 Splice Isoform Exhibits Neuronal Specific Cytoplasmic Aggregation and Contributes to TDP-43 Pathology in ALS

A C-Terminally Truncated TDP-43 Splice Isoform Exhibits Neuronal Specific Cytoplasmic Aggregation and Contributes to TDP-43 Pathology in ALS

Neuronal cytoplasmic aggregation and ubiquitination of TDP-43 is the most common disease pathology linking Amyotrophic Lateral Sclerosis (ALS) and frontotemporal lobar degeneration (FTLD). TDP-43 pathology is characterized by the presence of low molecular weight TDP-43 species generated through prot...

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Bibliographic Details
Main Authors: Marc Shenouda, Shangxi Xiao, Laura MacNair, Agnes Lau, Janice Robertson
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-06-01
Series:Frontiers in Neuroscience
Subjects:
TARDBP
TDP-43
amyotrophic lateral sclerosis
frontotemporal lobar degeneration
N-terminal fragment
C-splice variant
Online Access:https://www.frontiersin.org/articles/10.3389/fnins.2022.868556/full

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