The Pro-Oncogenic Protein IF<sub>1</sub> Promotes Proliferation of Anoxic Cancer Cells during Re-Oxygenation

The Pro-Oncogenic Protein IF<sub>1</sub> Promotes Proliferation of Anoxic Cancer Cells during Re-Oxygenation

Cancer cells overexpress IF<sub>1</sub>, the endogenous protein that inhibits the hydrolytic activity of ATP synthase when mitochondrial membrane potential (Δμ<sub>H</sub><sup>+</sup>) falls, as in ischemia. Other roles have been ascribed to IF<sub>1</sub...

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Bibliographic Details
Main Authors: Riccardo Righetti, Silvia Grillini, Valentina Del Dotto, Anna Costanzini, Francesca Liuzzi, Claudia Zanna, Gianluca Sgarbi, Giancarlo Solaini, Alessandra Baracca
Format: Article
Language:English
Published: MDPI AG 2023-09-01
Series:International Journal of Molecular Sciences
Subjects:
anoxia
mitochondria
ATP synthase
oxidative phosphorylation
metabolism
autophagy
Online Access:https://www.mdpi.com/1422-0067/24/19/14624

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