miR-29b Mediates the Chronic Inflammatory Response in Radiotherapy-Induced Vascular Disease
Summary: As a consequence of the success of present-day cancer treatment, radiotherapy-induced vascular disease is emerging. This disease is caused by chronic inflammatory activation and is likely orchestrated in part by microRNAs. In irradiated versus nonirradiated conduit arteries from patients re...
| Main Authors: | , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2019-02-01
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| Series: | JACC: Basic to Translational Science |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2452302X18302754 |
| _version_ | 1819159274145710080 |
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| author | Suzanne M. Eken, MD, PhD Tinna Christersdottir, MD Greg Winski, MD Traimate Sangsuwan, MSc Hong Jin, MD, PhD Ekaterina Chernogubova, PhD John Pirault, PhD Changyan Sun, MSc Nancy Simon, MSc Hanna Winter, MSc Alexandra Backlund, PhD Siamak Haghdoost, PhD Göran K. Hansson, MD, PhD Martin Halle, MD, PhD Lars Maegdefessel, MD, PhD |
| author_facet | Suzanne M. Eken, MD, PhD Tinna Christersdottir, MD Greg Winski, MD Traimate Sangsuwan, MSc Hong Jin, MD, PhD Ekaterina Chernogubova, PhD John Pirault, PhD Changyan Sun, MSc Nancy Simon, MSc Hanna Winter, MSc Alexandra Backlund, PhD Siamak Haghdoost, PhD Göran K. Hansson, MD, PhD Martin Halle, MD, PhD Lars Maegdefessel, MD, PhD |
| author_sort | Suzanne M. Eken, MD, PhD |
| collection | DOAJ |
| description | Summary: As a consequence of the success of present-day cancer treatment, radiotherapy-induced vascular disease is emerging. This disease is caused by chronic inflammatory activation and is likely orchestrated in part by microRNAs. In irradiated versus nonirradiated conduit arteries from patients receiving microvascular free tissue transfer reconstructions, irradiation resulted in down-regulation of miR-29b and up-regulation of miR-146b. miR-29b affected inflammation and adverse wound healing through its targets pentraxin-3 and dipeptidyl-peptidase 4. In vitro and in vivo, we showed that miR-29b overexpression therapy, through inhibition of pentraxin-3 and dipeptidyl-peptidase 4, could dampen the vascular inflammatory response. Key Words: arteriosclerosis, inflammation, microRNA, radiotherapy |
| first_indexed | 2024-12-22T16:37:57Z |
| format | Article |
| id | doaj.art-926ad42a8f694ea9b449c65f2a1f0718 |
| institution | Directory Open Access Journal |
| issn | 2452-302X |
| language | English |
| last_indexed | 2024-12-22T16:37:57Z |
| publishDate | 2019-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | JACC: Basic to Translational Science |
| spelling | doaj.art-926ad42a8f694ea9b449c65f2a1f07182022-12-21T18:19:55ZengElsevierJACC: Basic to Translational Science2452-302X2019-02-01417282miR-29b Mediates the Chronic Inflammatory Response in Radiotherapy-Induced Vascular DiseaseSuzanne M. Eken, MD, PhD0Tinna Christersdottir, MD1Greg Winski, MD2Traimate Sangsuwan, MSc3Hong Jin, MD, PhD4Ekaterina Chernogubova, PhD5John Pirault, PhD6Changyan Sun, MSc7Nancy Simon, MSc8Hanna Winter, MSc9Alexandra Backlund, PhD10Siamak Haghdoost, PhD11Göran K. Hansson, MD, PhD12Martin Halle, MD, PhD13Lars Maegdefessel, MD, PhD14Cardiovascular Medicine Unit, Department of Medicine, Solna, Karolinska Institute, Stockholm, SwedenDepartment of Molecular Medicine and Surgery, Karolinska Institute, Stockholm, SwedenCardiovascular Medicine Unit, Department of Medicine, Solna, Karolinska Institute, Stockholm, SwedenDepartment of Molecular Biosciences, Wenner-Gren Institute, Stockholm University, Stockholm, SwedenCardiovascular Medicine Unit, Department of Medicine, Solna, Karolinska Institute, Stockholm, SwedenCardiovascular Medicine Unit, Department of Medicine, Solna, Karolinska Institute, Stockholm, SwedenINSERM UMR_S1116, Université de Lorraine, Vandoeuvre-lès-Nancy, FranceCardiovascular Medicine Unit, Department of Medicine, Solna, Karolinska Institute, Stockholm, SwedenCardiovascular Medicine Unit, Department of Medicine, Solna, Karolinska Institute, Stockholm, SwedenTechnical University Munich, Department of Vascular and Endovascular Surgery, Munich, Germany; German Center for Cardiovascular Research (DZHK) partner site Munich, Munich, GermanyCardiovascular Medicine Unit, Department of Medicine, Solna, Karolinska Institute, Stockholm, SwedenDepartment of Molecular Biosciences, Wenner-Gren Institute, Stockholm University, Stockholm, Sweden; University of Caen Normandie, LARIA–CIMAP, Caen, FranceCardiovascular Medicine Unit, Department of Medicine, Solna, Karolinska Institute, Stockholm, SwedenDepartment of Molecular Medicine and Surgery, Karolinska Institute, Stockholm, Sweden; Department of Reconstructive Plastic Surgery, Karolinska University Hospital, Stockholm, SwedenCardiovascular Medicine Unit, Department of Medicine, Solna, Karolinska Institute, Stockholm, Sweden; Technical University Munich, Department of Vascular and Endovascular Surgery, Munich, Germany; German Center for Cardiovascular Research (DZHK) partner site Munich, Munich, Germany; Address for correspondence: Dr. Lars Maegdefessel, Karolinska Institute, Department of Medicine, Solna, 171 76 Stockholm, Sweden.Summary: As a consequence of the success of present-day cancer treatment, radiotherapy-induced vascular disease is emerging. This disease is caused by chronic inflammatory activation and is likely orchestrated in part by microRNAs. In irradiated versus nonirradiated conduit arteries from patients receiving microvascular free tissue transfer reconstructions, irradiation resulted in down-regulation of miR-29b and up-regulation of miR-146b. miR-29b affected inflammation and adverse wound healing through its targets pentraxin-3 and dipeptidyl-peptidase 4. In vitro and in vivo, we showed that miR-29b overexpression therapy, through inhibition of pentraxin-3 and dipeptidyl-peptidase 4, could dampen the vascular inflammatory response. Key Words: arteriosclerosis, inflammation, microRNA, radiotherapyhttp://www.sciencedirect.com/science/article/pii/S2452302X18302754 |
| spellingShingle | Suzanne M. Eken, MD, PhD Tinna Christersdottir, MD Greg Winski, MD Traimate Sangsuwan, MSc Hong Jin, MD, PhD Ekaterina Chernogubova, PhD John Pirault, PhD Changyan Sun, MSc Nancy Simon, MSc Hanna Winter, MSc Alexandra Backlund, PhD Siamak Haghdoost, PhD Göran K. Hansson, MD, PhD Martin Halle, MD, PhD Lars Maegdefessel, MD, PhD miR-29b Mediates the Chronic Inflammatory Response in Radiotherapy-Induced Vascular Disease JACC: Basic to Translational Science |
| title | miR-29b Mediates the Chronic Inflammatory Response in Radiotherapy-Induced Vascular Disease |
| title_full | miR-29b Mediates the Chronic Inflammatory Response in Radiotherapy-Induced Vascular Disease |
| title_fullStr | miR-29b Mediates the Chronic Inflammatory Response in Radiotherapy-Induced Vascular Disease |
| title_full_unstemmed | miR-29b Mediates the Chronic Inflammatory Response in Radiotherapy-Induced Vascular Disease |
| title_short | miR-29b Mediates the Chronic Inflammatory Response in Radiotherapy-Induced Vascular Disease |
| title_sort | mir 29b mediates the chronic inflammatory response in radiotherapy induced vascular disease |
| url | http://www.sciencedirect.com/science/article/pii/S2452302X18302754 |
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