Residential greenness, asthma, and lung function among children at high risk of allergic sensitization: a prospective cohort study
Abstract Background While benefits of greenness to health have been reported, findings specific to child respiratory health are inconsistent. Methods We utilized a prospective birth cohort followed from birth to age 7 years (n = 617). Residential surrounding greenness was quantified via Normalized D...
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| Format: | Article |
| Language: | English |
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BMC
2022-05-01
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| Series: | Environmental Health |
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| Online Access: | https://doi.org/10.1186/s12940-022-00864-w |
| _version_ | 1818210485750726656 |
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| author | Kim Hartley Patrick H. Ryan Gordon L. Gillespie Joseph Perazzo J. Michael Wright Glenn E. Rice Geoffrey H. Donovan Rebecca Gernes Gurjit K. Khurana Hershey Grace LeMasters Cole Brokamp |
| author_facet | Kim Hartley Patrick H. Ryan Gordon L. Gillespie Joseph Perazzo J. Michael Wright Glenn E. Rice Geoffrey H. Donovan Rebecca Gernes Gurjit K. Khurana Hershey Grace LeMasters Cole Brokamp |
| author_sort | Kim Hartley |
| collection | DOAJ |
| description | Abstract Background While benefits of greenness to health have been reported, findings specific to child respiratory health are inconsistent. Methods We utilized a prospective birth cohort followed from birth to age 7 years (n = 617). Residential surrounding greenness was quantified via Normalized Difference Vegetation Index (NDVI) within 200, 400, and 800 m distances from geocoded home addresses at birth, age 7 years, and across childhood. Respiratory health outcomes were assessed at age 7 years, including asthma and lung function [percent predicted forced expiratory volume in the first second (%FEV1), percent predicted forced vital capacity (%FVC), and percent predicted ratio of forced expiratory volume in the first second to forced vital capacity (%FEV1/FVC)]. We assessed associations using linear and logistic regression models adjusted for community deprivation, household income, and traffic-related air pollution. We tested for effect measure modification by atopic status. Results We noted evidence of positive confounding as inverse associations were attenuated upon adjustment in the multivariable models. We found evidence of effect measure modification of NDVI and asthma within 400 m at age 7 years by atopic status (p = 0.04), whereby children sensitized to common allergens were more likely to develop asthma as exposure to greenness increased (OR = 1.3, 95% CI: 0.9, 2.0) versus children not sensitized to common allergens (OR = 0.8, 95% CI: 0.5, 1.2). We found consistently positive associations between NDVI and %FEV1 and %FVC which similarly evidenced positive confounding upon adjustment. In the adjusted regression models, NDVI at 7 years of age was associated with %FEV1 (200 m: β = 2.1, 95% CI: 0.1, 3.3; 400 m: β = 1.6, 95% CI: 0.3, 2.9) and %FVC (200 m: β = 1.8, 95% CI: 0.7, 3.0; 400 m: β = 1.6, 95% CI: 0.3, 2.8; 800 m: β = 1.5, 95% CI: 0.1, 2.8). Adjusted results for %FEV1/FVC were non-significant except exposure at birth in the 400 m buffer (β = 0.81, 95% CI: 0.1, 1.5). We found no evidence of effect measure modification of NDVI by atopic status for objective measures of lung function. Conclusion Sensitivity to allergens may modify the effect of greenness on risk for asthma in children but greenness is likely beneficial for concurrent lung function regardless of allergic status. |
| first_indexed | 2024-12-12T05:17:22Z |
| format | Article |
| id | doaj.art-926d5b5e97e943e8a9e9e76a8a1e8c1a |
| institution | Directory Open Access Journal |
| issn | 1476-069X |
| language | English |
| last_indexed | 2024-12-12T05:17:22Z |
| publishDate | 2022-05-01 |
| publisher | BMC |
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| series | Environmental Health |
| spelling | doaj.art-926d5b5e97e943e8a9e9e76a8a1e8c1a2022-12-22T00:36:43ZengBMCEnvironmental Health1476-069X2022-05-0121111110.1186/s12940-022-00864-wResidential greenness, asthma, and lung function among children at high risk of allergic sensitization: a prospective cohort studyKim Hartley0Patrick H. Ryan1Gordon L. Gillespie2Joseph Perazzo3J. Michael Wright4Glenn E. Rice5Geoffrey H. Donovan6Rebecca Gernes7Gurjit K. Khurana Hershey8Grace LeMasters9Cole Brokamp10Cincinnati Children’s Hospital Medical CenterCincinnati Children’s Hospital Medical CenterCollege of Nursing, University of CincinnatiCollege of Nursing, University of CincinnatiToxic Effects Assessment Branch (Cincinnati), Chemical and Pollutant Assessment Division, Center for Public Health and Environmental Assessment (CPHEA), Office of Research and Development, U.S. Environmental Protection AgencyToxic Effects Assessment Branch (Cincinnati), Chemical and Pollutant Assessment Division, Center for Public Health and Environmental Assessment (CPHEA), Office of Research and Development, U.S. Environmental Protection AgencyUSDA Forest Service, PNW Research StationAssociation of Schools and Programs of Public Health (ASPPH), Environmental Health Research Participant, 2014-2016Cincinnati Children’s Hospital Medical CenterCollege of Medicine, University of CincinnatiCincinnati Children’s Hospital Medical CenterAbstract Background While benefits of greenness to health have been reported, findings specific to child respiratory health are inconsistent. Methods We utilized a prospective birth cohort followed from birth to age 7 years (n = 617). Residential surrounding greenness was quantified via Normalized Difference Vegetation Index (NDVI) within 200, 400, and 800 m distances from geocoded home addresses at birth, age 7 years, and across childhood. Respiratory health outcomes were assessed at age 7 years, including asthma and lung function [percent predicted forced expiratory volume in the first second (%FEV1), percent predicted forced vital capacity (%FVC), and percent predicted ratio of forced expiratory volume in the first second to forced vital capacity (%FEV1/FVC)]. We assessed associations using linear and logistic regression models adjusted for community deprivation, household income, and traffic-related air pollution. We tested for effect measure modification by atopic status. Results We noted evidence of positive confounding as inverse associations were attenuated upon adjustment in the multivariable models. We found evidence of effect measure modification of NDVI and asthma within 400 m at age 7 years by atopic status (p = 0.04), whereby children sensitized to common allergens were more likely to develop asthma as exposure to greenness increased (OR = 1.3, 95% CI: 0.9, 2.0) versus children not sensitized to common allergens (OR = 0.8, 95% CI: 0.5, 1.2). We found consistently positive associations between NDVI and %FEV1 and %FVC which similarly evidenced positive confounding upon adjustment. In the adjusted regression models, NDVI at 7 years of age was associated with %FEV1 (200 m: β = 2.1, 95% CI: 0.1, 3.3; 400 m: β = 1.6, 95% CI: 0.3, 2.9) and %FVC (200 m: β = 1.8, 95% CI: 0.7, 3.0; 400 m: β = 1.6, 95% CI: 0.3, 2.8; 800 m: β = 1.5, 95% CI: 0.1, 2.8). Adjusted results for %FEV1/FVC were non-significant except exposure at birth in the 400 m buffer (β = 0.81, 95% CI: 0.1, 1.5). We found no evidence of effect measure modification of NDVI by atopic status for objective measures of lung function. Conclusion Sensitivity to allergens may modify the effect of greenness on risk for asthma in children but greenness is likely beneficial for concurrent lung function regardless of allergic status.https://doi.org/10.1186/s12940-022-00864-wPediatricChildGreenspaceGreen spaceRespiratoryAllergy |
| spellingShingle | Kim Hartley Patrick H. Ryan Gordon L. Gillespie Joseph Perazzo J. Michael Wright Glenn E. Rice Geoffrey H. Donovan Rebecca Gernes Gurjit K. Khurana Hershey Grace LeMasters Cole Brokamp Residential greenness, asthma, and lung function among children at high risk of allergic sensitization: a prospective cohort study Environmental Health Pediatric Child Greenspace Green space Respiratory Allergy |
| title | Residential greenness, asthma, and lung function among children at high risk of allergic sensitization: a prospective cohort study |
| title_full | Residential greenness, asthma, and lung function among children at high risk of allergic sensitization: a prospective cohort study |
| title_fullStr | Residential greenness, asthma, and lung function among children at high risk of allergic sensitization: a prospective cohort study |
| title_full_unstemmed | Residential greenness, asthma, and lung function among children at high risk of allergic sensitization: a prospective cohort study |
| title_short | Residential greenness, asthma, and lung function among children at high risk of allergic sensitization: a prospective cohort study |
| title_sort | residential greenness asthma and lung function among children at high risk of allergic sensitization a prospective cohort study |
| topic | Pediatric Child Greenspace Green space Respiratory Allergy |
| url | https://doi.org/10.1186/s12940-022-00864-w |
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