The effect of tarantula cubensis extract on gentamicin-induced acute kidney injury in ovariectomized rats
This study examined the effect of Tarantula cubensis extract (TCE) on gentamicin-induced acute kidney injury in ovariectomized rats. A total of 40 female Wistar albino rats were randomly divided equally into five groups: control (C), ovariectomy (O), Tarantula cubensis (OT), gentamicin (OG), and gen...
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| Format: | Article |
| Language: | English |
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Kafkas University, Faculty of Veterinary Medicine
2021-09-01
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| Series: | Kafkas Universitesi Veteriner Fakültesi Dergisi |
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| Online Access: | https://vetdergikafkas.org/pdf.php?id=2842 |
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| author | Enes AKYÜZ Mustafa MAKAV Mushap KURU Pınar BAYRAM |
| author_facet | Enes AKYÜZ Mustafa MAKAV Mushap KURU Pınar BAYRAM |
| author_sort | Enes AKYÜZ |
| collection | DOAJ |
| description | This study examined the effect of Tarantula cubensis extract (TCE) on gentamicin-induced acute kidney injury in ovariectomized rats. A total of 40 female Wistar albino rats were randomly divided equally into five groups: control (C), ovariectomy (O), Tarantula cubensis (OT), gentamicin (OG), and gentamicin + Tarantula cubensis (OGT). All rats except those in the C were ovariectomized. Kidney damage was created with gentamicin for OG and OGT. The OT and OGT were treated with a single dose of TCE. Blood, sera, and kidney tissue were taken at necropsy for evaluation. Total leukocyte count was higher in the OT compared to the others (P=0.002). Significant increases were also determined in serum urea, creatinine, aspartate aminotransferase, and total protein levels in the OT, OG, and OGT compared to the C and O. The glutathione level was low in the serum and kidney tissue of the OG, and the malondialdehyde level was high compared to the others (P<0.05). As a result of the use of TCE in gentamicin-induced acute kidney injury in ovariectomized rats, serum creatinine, urea, and malondialdehyde levels decreased in the OGT compared to the OG, the glutathione level increased, and the severity of histopathological findings decreased to milder levels. As a result; single dose of TCE partially reduced kidney damage in rats with gentamicin-induced acute kidney injury. |
| first_indexed | 2024-03-13T04:39:30Z |
| format | Article |
| id | doaj.art-9272088e3aee4c1db34cf4d711c43394 |
| institution | Directory Open Access Journal |
| issn | 1309-2251 |
| language | English |
| last_indexed | 2024-03-13T04:39:30Z |
| publishDate | 2021-09-01 |
| publisher | Kafkas University, Faculty of Veterinary Medicine |
| record_format | Article |
| series | Kafkas Universitesi Veteriner Fakültesi Dergisi |
| spelling | doaj.art-9272088e3aee4c1db34cf4d711c433942023-06-19T06:29:11ZengKafkas University, Faculty of Veterinary MedicineKafkas Universitesi Veteriner Fakültesi Dergisi1309-22512021-09-0127555956610.9775/kvfd.2021.253902842The effect of tarantula cubensis extract on gentamicin-induced acute kidney injury in ovariectomized ratsEnes AKYÜZMustafa MAKAV0Mushap KURU1Pınar BAYRAM2Kafkas University, Faculty of Veterinary Medicine, Department of Physiology, TR-36100. Kars - TURKEYKafkas University, Faculty of Veterinary Medicine, Department of Obstetrics and Gynecology, TR-36100 Kars - TURKEYKafkas University, Faculty of Medicine, Department of Histology and Embryology, 36100 Kars - TURKEYThis study examined the effect of Tarantula cubensis extract (TCE) on gentamicin-induced acute kidney injury in ovariectomized rats. A total of 40 female Wistar albino rats were randomly divided equally into five groups: control (C), ovariectomy (O), Tarantula cubensis (OT), gentamicin (OG), and gentamicin + Tarantula cubensis (OGT). All rats except those in the C were ovariectomized. Kidney damage was created with gentamicin for OG and OGT. The OT and OGT were treated with a single dose of TCE. Blood, sera, and kidney tissue were taken at necropsy for evaluation. Total leukocyte count was higher in the OT compared to the others (P=0.002). Significant increases were also determined in serum urea, creatinine, aspartate aminotransferase, and total protein levels in the OT, OG, and OGT compared to the C and O. The glutathione level was low in the serum and kidney tissue of the OG, and the malondialdehyde level was high compared to the others (P<0.05). As a result of the use of TCE in gentamicin-induced acute kidney injury in ovariectomized rats, serum creatinine, urea, and malondialdehyde levels decreased in the OGT compared to the OG, the glutathione level increased, and the severity of histopathological findings decreased to milder levels. As a result; single dose of TCE partially reduced kidney damage in rats with gentamicin-induced acute kidney injury.https://vetdergikafkas.org/pdf.php?id=2842acute kidney injurygentamicinrattarantula cubensis |
| spellingShingle | Enes AKYÜZ Mustafa MAKAV Mushap KURU Pınar BAYRAM The effect of tarantula cubensis extract on gentamicin-induced acute kidney injury in ovariectomized rats Kafkas Universitesi Veteriner Fakültesi Dergisi acute kidney injury gentamicin rat tarantula cubensis |
| title | The effect of tarantula cubensis extract on gentamicin-induced acute kidney injury in ovariectomized rats |
| title_full | The effect of tarantula cubensis extract on gentamicin-induced acute kidney injury in ovariectomized rats |
| title_fullStr | The effect of tarantula cubensis extract on gentamicin-induced acute kidney injury in ovariectomized rats |
| title_full_unstemmed | The effect of tarantula cubensis extract on gentamicin-induced acute kidney injury in ovariectomized rats |
| title_short | The effect of tarantula cubensis extract on gentamicin-induced acute kidney injury in ovariectomized rats |
| title_sort | effect of tarantula cubensis extract on gentamicin induced acute kidney injury in ovariectomized rats |
| topic | acute kidney injury gentamicin rat tarantula cubensis |
| url | https://vetdergikafkas.org/pdf.php?id=2842 |
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