Impact of tissue atrophy on high-pass filtered MRI signal phase-based assessment in large-scale group-comparison studies: A simulation study
The assessment of abnormal accumulation of tissue iron in the basal ganglia nuclei and in white matter plaques using the gradient echo magnetic resonance signal phase has become a research focus in many neurodegenerative diseases such as multiple sclerosis or Parkinson’s disease. A common and natura...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2013-10-01
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| Series: | Frontiers in Physics |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fphy.2013.00014/full |
| _version_ | 1819087401902931968 |
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| author | Ferdinand eSchweser Michael G Dwyer Andreas eDeistung Jürgen R. Reichenbach Robert eZivadinov Robert eZivadinov |
| author_facet | Ferdinand eSchweser Michael G Dwyer Andreas eDeistung Jürgen R. Reichenbach Robert eZivadinov Robert eZivadinov |
| author_sort | Ferdinand eSchweser |
| collection | DOAJ |
| description | The assessment of abnormal accumulation of tissue iron in the basal ganglia nuclei and in white matter plaques using the gradient echo magnetic resonance signal phase has become a research focus in many neurodegenerative diseases such as multiple sclerosis or Parkinson’s disease. A common and natural approach is to calculate the mean high-pass-filtered phase of previously delineated brain structures. Unfortunately, the interpretation of such an analysis requires caution: in this paper we demonstrate that regional gray matter atrophy, which is concomitant with many neurodegenerative diseases, may itself directly result in a phase shift seemingly indicative of increased iron concentration even without any real change in the tissue iron concentration. Although this effect is relatively small results of large-scale group comparisons may be driven by anatomical changes rather than by changes of the iron concentration. |
| first_indexed | 2024-12-21T21:35:34Z |
| format | Article |
| id | doaj.art-9274547d8d8748da8964e9ca039927b8 |
| institution | Directory Open Access Journal |
| issn | 2296-424X |
| language | English |
| last_indexed | 2024-12-21T21:35:34Z |
| publishDate | 2013-10-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Physics |
| spelling | doaj.art-9274547d8d8748da8964e9ca039927b82022-12-21T18:49:30ZengFrontiers Media S.A.Frontiers in Physics2296-424X2013-10-01110.3389/fphy.2013.0001457188Impact of tissue atrophy on high-pass filtered MRI signal phase-based assessment in large-scale group-comparison studies: A simulation studyFerdinand eSchweser0Michael G Dwyer1Andreas eDeistung2Jürgen R. Reichenbach3Robert eZivadinov4Robert eZivadinov5Jena University Hospital - Friedrich Schiller University JenaUniversity at Buffalo, State University of New YorkJena University Hospital - Friedrich Schiller University JenaJena University Hospital - Friedrich Schiller University JenaUniversity at Buffalo, State University of New YorkUniversity at Buffalo, State University of New YorkThe assessment of abnormal accumulation of tissue iron in the basal ganglia nuclei and in white matter plaques using the gradient echo magnetic resonance signal phase has become a research focus in many neurodegenerative diseases such as multiple sclerosis or Parkinson’s disease. A common and natural approach is to calculate the mean high-pass-filtered phase of previously delineated brain structures. Unfortunately, the interpretation of such an analysis requires caution: in this paper we demonstrate that regional gray matter atrophy, which is concomitant with many neurodegenerative diseases, may itself directly result in a phase shift seemingly indicative of increased iron concentration even without any real change in the tissue iron concentration. Although this effect is relatively small results of large-scale group comparisons may be driven by anatomical changes rather than by changes of the iron concentration.http://journal.frontiersin.org/Journal/10.3389/fphy.2013.00014/fullAtrophymagnetic susceptibilityMRIartifactsPhase imagingtissue iron |
| spellingShingle | Ferdinand eSchweser Michael G Dwyer Andreas eDeistung Jürgen R. Reichenbach Robert eZivadinov Robert eZivadinov Impact of tissue atrophy on high-pass filtered MRI signal phase-based assessment in large-scale group-comparison studies: A simulation study Frontiers in Physics Atrophy magnetic susceptibility MRI artifacts Phase imaging tissue iron |
| title | Impact of tissue atrophy on high-pass filtered MRI signal phase-based assessment in large-scale group-comparison studies: A simulation study |
| title_full | Impact of tissue atrophy on high-pass filtered MRI signal phase-based assessment in large-scale group-comparison studies: A simulation study |
| title_fullStr | Impact of tissue atrophy on high-pass filtered MRI signal phase-based assessment in large-scale group-comparison studies: A simulation study |
| title_full_unstemmed | Impact of tissue atrophy on high-pass filtered MRI signal phase-based assessment in large-scale group-comparison studies: A simulation study |
| title_short | Impact of tissue atrophy on high-pass filtered MRI signal phase-based assessment in large-scale group-comparison studies: A simulation study |
| title_sort | impact of tissue atrophy on high pass filtered mri signal phase based assessment in large scale group comparison studies a simulation study |
| topic | Atrophy magnetic susceptibility MRI artifacts Phase imaging tissue iron |
| url | http://journal.frontiersin.org/Journal/10.3389/fphy.2013.00014/full |
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