An Outside-In Switch in Integrin Signaling Caused by Chemical and Mechanical Signals in Reactive Astrocytes

An Outside-In Switch in Integrin Signaling Caused by Chemical and Mechanical Signals in Reactive Astrocytes

Astrocyte reactivity is associated with poor repair capacity after injury to the brain, where chemical and physical changes occur in the damaged zone. Astrocyte surface proteins, such as integrins, are upregulated, and the release of pro-inflammatory molecules and extracellular matrix (ECM) proteins...

Full description

Bibliographic Details
Main Authors: Leonardo A. Pérez, Aysha Rashid, J. Dale Combs, Pascal Schneider, Andrés Rodríguez, Khalid Salaita, Lisette Leyton
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-08-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
integrin
mechanotransduction
astrocyte
Thy-1 (CD90)
cell contractility
astrogliosis
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2021.712627/full

Similar Items

Similar Items