Triglyceride-glucose body mass index predicts prognosis in patients with ST-elevation myocardial infarction
Abstract Triglyceride glycemic-body mass index (TyG-BMI) is a simple and reliable surrogate for insulin resistance (IR). However, it is still unclear if TyG-BMI has any predictive value in patients having percutaneous coronary intervention (PCI) for ST-segment elevation myocardial infarction (STEMI)...
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| Format: | Article |
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Nature Portfolio
2024-01-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-023-51136-7 |
| _version_ | 1797355799523098624 |
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| author | Ming Liu Jianyuan Pan Ke Meng Yuwei Wang Xueqing Sun Likun Ma Xiaofan Yu |
| author_facet | Ming Liu Jianyuan Pan Ke Meng Yuwei Wang Xueqing Sun Likun Ma Xiaofan Yu |
| author_sort | Ming Liu |
| collection | DOAJ |
| description | Abstract Triglyceride glycemic-body mass index (TyG-BMI) is a simple and reliable surrogate for insulin resistance (IR). However, it is still unclear if TyG-BMI has any predictive value in patients having percutaneous coronary intervention (PCI) for ST-segment elevation myocardial infarction (STEMI). The purpose of this study was to examine the TyG-BMI index's prognostic significance and predictive power in patients with STEMI. The study comprised a total of 2648 consecutive STEMI patients who underwent PCI. The primary endpoint was the occurrence of major adverse cardiovascular events (MACE), defined as the combination of all-cause death, nonfatal myocardial infarction, nonfatal stroke, and coronary revascularization. The TyG-BMI index was formulated as ln [fasting triglycerides (mg/dL) × fasting plasma glucose (mg/dL)/2] × BMI. 193 patients in all experienced MACE over a median follow-up of 14.7 months. There was a statistically significant difference between the Kaplan–Meier survival curves for the TyG-BMI index tertiles (log-rank test, p = 0.019) for the cumulative incidence of MACE. The adjusted HRs for the incidence of MACE in the middle and highest quartiles of the TyG-BMI index compared with the lowest quartile were 1.37 (95% CI 0.92, 2.03) and 1.53 (95% CI 1.02, 2.29), respectively, in the fully adjusted Cox regression model. At six months, one year, and three years, the TyG-BMI area under the curve (AUC) for predicting MACE was 0.691, 0.666, and 0.637, respectively. Additionally, adding the TyG-BMI index to the risk prediction model enhanced outcome prediction. In STEMI patients undergoing PCI, TyG-BMI was independently linked to MACE. TyG-BMI could be a simple and solid way to assess MACE risk and prognosis. |
| first_indexed | 2024-03-08T14:17:20Z |
| format | Article |
| id | doaj.art-927993008b7345448b7ab737217618ef |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-03-08T14:17:20Z |
| publishDate | 2024-01-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-927993008b7345448b7ab737217618ef2024-01-14T12:20:32ZengNature PortfolioScientific Reports2045-23222024-01-0114111310.1038/s41598-023-51136-7Triglyceride-glucose body mass index predicts prognosis in patients with ST-elevation myocardial infarctionMing Liu0Jianyuan Pan1Ke Meng2Yuwei Wang3Xueqing Sun4Likun Ma5Xiaofan Yu6Department of Cardiology, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of ChinaDepartment of Cardiology, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of ChinaDepartment of Cardiology, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of ChinaDepartment of Cardiology, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of ChinaThe Second Hospital of Jilin UniversityDepartment of Cardiology, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of ChinaDepartment of Cardiology, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of ChinaAbstract Triglyceride glycemic-body mass index (TyG-BMI) is a simple and reliable surrogate for insulin resistance (IR). However, it is still unclear if TyG-BMI has any predictive value in patients having percutaneous coronary intervention (PCI) for ST-segment elevation myocardial infarction (STEMI). The purpose of this study was to examine the TyG-BMI index's prognostic significance and predictive power in patients with STEMI. The study comprised a total of 2648 consecutive STEMI patients who underwent PCI. The primary endpoint was the occurrence of major adverse cardiovascular events (MACE), defined as the combination of all-cause death, nonfatal myocardial infarction, nonfatal stroke, and coronary revascularization. The TyG-BMI index was formulated as ln [fasting triglycerides (mg/dL) × fasting plasma glucose (mg/dL)/2] × BMI. 193 patients in all experienced MACE over a median follow-up of 14.7 months. There was a statistically significant difference between the Kaplan–Meier survival curves for the TyG-BMI index tertiles (log-rank test, p = 0.019) for the cumulative incidence of MACE. The adjusted HRs for the incidence of MACE in the middle and highest quartiles of the TyG-BMI index compared with the lowest quartile were 1.37 (95% CI 0.92, 2.03) and 1.53 (95% CI 1.02, 2.29), respectively, in the fully adjusted Cox regression model. At six months, one year, and three years, the TyG-BMI area under the curve (AUC) for predicting MACE was 0.691, 0.666, and 0.637, respectively. Additionally, adding the TyG-BMI index to the risk prediction model enhanced outcome prediction. In STEMI patients undergoing PCI, TyG-BMI was independently linked to MACE. TyG-BMI could be a simple and solid way to assess MACE risk and prognosis.https://doi.org/10.1038/s41598-023-51136-7 |
| spellingShingle | Ming Liu Jianyuan Pan Ke Meng Yuwei Wang Xueqing Sun Likun Ma Xiaofan Yu Triglyceride-glucose body mass index predicts prognosis in patients with ST-elevation myocardial infarction Scientific Reports |
| title | Triglyceride-glucose body mass index predicts prognosis in patients with ST-elevation myocardial infarction |
| title_full | Triglyceride-glucose body mass index predicts prognosis in patients with ST-elevation myocardial infarction |
| title_fullStr | Triglyceride-glucose body mass index predicts prognosis in patients with ST-elevation myocardial infarction |
| title_full_unstemmed | Triglyceride-glucose body mass index predicts prognosis in patients with ST-elevation myocardial infarction |
| title_short | Triglyceride-glucose body mass index predicts prognosis in patients with ST-elevation myocardial infarction |
| title_sort | triglyceride glucose body mass index predicts prognosis in patients with st elevation myocardial infarction |
| url | https://doi.org/10.1038/s41598-023-51136-7 |
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