Acute and Sub-acute Toxicity of Ganoderma applanatum (Pres.) Pat. Extract Mediated Silver Nanoparticles on Rat
Ganoderm applanatum is a polypore macrofungi and traditionally used as medicine rather than fodder. Silver nanoparticles mediated by G. applanatum extract were synthesized, characterized and toxicity impacts were investigated for their pharmacological and medicinal uses. The synthesized silver nanop...
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| Format: | Article |
| Language: | English |
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Society of Land Measurements and Cadastre from Transylvania (SMTCT)
2019-09-01
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| Series: | Notulae Scientia Biologicae |
| Subjects: | |
| Online Access: | https://www.notulaebiologicae.ro/index.php/nsb/article/view/10473 |
| _version_ | 1818176887302651904 |
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| author | Sukumar DANDAPAT Manoj KUMAR Rakesh RANJAN Manoranjan P. SINHA |
| author_facet | Sukumar DANDAPAT Manoj KUMAR Rakesh RANJAN Manoranjan P. SINHA |
| author_sort | Sukumar DANDAPAT |
| collection | DOAJ |
| description | Ganoderm applanatum is a polypore macrofungi and traditionally used as medicine rather than fodder. Silver nanoparticles mediated by G. applanatum extract were synthesized, characterized and toxicity impacts were investigated for their pharmacological and medicinal uses. The synthesized silver nanoparticles were of average 58.78 nm in diameter with -13.8 mV zetpotential, analysed by dynamic light scattering method. Fourier transform infrared spectroscopy analysis of synthesized nanoparticles confirmed the capping and stabilizing with mycochemicals, that showed transmittance at 3606 cm-1 corresponds to O-H stretch for phenol, 2430 cm-1 corresponds to N-H stretch for primary and secondary amines. 2000 mg kg-1, 200 mg kg-1 and 400 mg kg-1 doses of silver nanoparticles showed non-significant (p<0.05) increase in body weight and organ weight. Non-significant increase in RBC indices were observed and significant (p<0.05) increase in WBC count (7.28±0.41 × 103 µL-1 and 8.41±0.35 × 103 µL-1) at 200 mg kg-1 and 400 mg kg-1 doses of silver nanoparticles were observed. Thus, G. applanatum extract mediated silver nanoparticles can be used pharmacologically and medicinally due to their nontoxic effect. |
| first_indexed | 2024-12-11T20:23:20Z |
| format | Article |
| id | doaj.art-92811b1b308e46aa9163a3063320cb89 |
| institution | Directory Open Access Journal |
| issn | 2067-3205 2067-3264 |
| language | English |
| last_indexed | 2024-12-11T20:23:20Z |
| publishDate | 2019-09-01 |
| publisher | Society of Land Measurements and Cadastre from Transylvania (SMTCT) |
| record_format | Article |
| series | Notulae Scientia Biologicae |
| spelling | doaj.art-92811b1b308e46aa9163a3063320cb892022-12-22T00:52:02ZengSociety of Land Measurements and Cadastre from Transylvania (SMTCT)Notulae Scientia Biologicae2067-32052067-32642019-09-0111310.15835/nsb11310473Acute and Sub-acute Toxicity of Ganoderma applanatum (Pres.) Pat. Extract Mediated Silver Nanoparticles on RatSukumar DANDAPAT0Manoj KUMAR1Rakesh RANJAN2Manoranjan P. SINHA3Ranchi University, Department of Zoology, Ranchi, 834008, JharkhandSt. Xavier’s College, Department of Zoology, Ranchi, 834001, JharkhandRanchi University, Department of Zoology, Ranchi, 834008, JharkhandRanchi University, Department of Zoology, Ranchi, 834008, JharkhandGanoderm applanatum is a polypore macrofungi and traditionally used as medicine rather than fodder. Silver nanoparticles mediated by G. applanatum extract were synthesized, characterized and toxicity impacts were investigated for their pharmacological and medicinal uses. The synthesized silver nanoparticles were of average 58.78 nm in diameter with -13.8 mV zetpotential, analysed by dynamic light scattering method. Fourier transform infrared spectroscopy analysis of synthesized nanoparticles confirmed the capping and stabilizing with mycochemicals, that showed transmittance at 3606 cm-1 corresponds to O-H stretch for phenol, 2430 cm-1 corresponds to N-H stretch for primary and secondary amines. 2000 mg kg-1, 200 mg kg-1 and 400 mg kg-1 doses of silver nanoparticles showed non-significant (p<0.05) increase in body weight and organ weight. Non-significant increase in RBC indices were observed and significant (p<0.05) increase in WBC count (7.28±0.41 × 103 µL-1 and 8.41±0.35 × 103 µL-1) at 200 mg kg-1 and 400 mg kg-1 doses of silver nanoparticles were observed. Thus, G. applanatum extract mediated silver nanoparticles can be used pharmacologically and medicinally due to their nontoxic effect.https://www.notulaebiologicae.ro/index.php/nsb/article/view/10473fungi; haematology; medicine; nanoparticles; toxicity |
| spellingShingle | Sukumar DANDAPAT Manoj KUMAR Rakesh RANJAN Manoranjan P. SINHA Acute and Sub-acute Toxicity of Ganoderma applanatum (Pres.) Pat. Extract Mediated Silver Nanoparticles on Rat Notulae Scientia Biologicae fungi; haematology; medicine; nanoparticles; toxicity |
| title | Acute and Sub-acute Toxicity of Ganoderma applanatum (Pres.) Pat. Extract Mediated Silver Nanoparticles on Rat |
| title_full | Acute and Sub-acute Toxicity of Ganoderma applanatum (Pres.) Pat. Extract Mediated Silver Nanoparticles on Rat |
| title_fullStr | Acute and Sub-acute Toxicity of Ganoderma applanatum (Pres.) Pat. Extract Mediated Silver Nanoparticles on Rat |
| title_full_unstemmed | Acute and Sub-acute Toxicity of Ganoderma applanatum (Pres.) Pat. Extract Mediated Silver Nanoparticles on Rat |
| title_short | Acute and Sub-acute Toxicity of Ganoderma applanatum (Pres.) Pat. Extract Mediated Silver Nanoparticles on Rat |
| title_sort | acute and sub acute toxicity of ganoderma applanatum pres pat extract mediated silver nanoparticles on rat |
| topic | fungi; haematology; medicine; nanoparticles; toxicity |
| url | https://www.notulaebiologicae.ro/index.php/nsb/article/view/10473 |
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