Unequal burden of Zika-associated microcephaly among populations with public and private healthcare in Salvador, Brazil

Unequal burden of Zika-associated microcephaly among populations with public and private healthcare in Salvador, Brazil

Objectives: To describe the differences in clinical presentation and relative disease burden of congenital Zika syndrome (CZS)-associated microcephaly at 2 large hospitals in Salvador, Brazil that serve patients of different socioeconomic status (SES). Methods: Clinical and serologic data were colle...

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Main Authors: Adeolu Aromolaran, Katiaci Araujo, Joseph B. Ladines-Lim, Nivison Nery, Jr., Mateus S. do Rosário, Valmir N. Rastely, Jr., Gracinda Archanjo, Dina Daltro, Gustavo Baltazar da Silveira Carvalho, Kleber Pimentel, João Ricardo Maltez de Almeida, Isadora Cristina de Siqueira, Hugo C. Ribeiro, Jamary Oliveira-Filho, Daiana de Oliveira, Daniele F. Henriques, Sueli G. Rodrigues, Pedro F. da Costa Vasconcelos, Antonio R.P. de Almeida, Gielson A. Sacramento, Jaqueline S. Cruz, Manoel Sarno, Bruno de Paula Freitas, Adriana Mattos, Ricardo Khouri, Mitermayer G. Reis, Albert I. Ko, Federico Costa
Format: Article
Language:English
Published: Elsevier 2022-07-01
Series:International Journal of Infectious Diseases
Subjects:
Zika Virus
Microcephaly
Fetus
Socioeconomic Status
Online Access:http://www.sciencedirect.com/science/article/pii/S120197122200234X
Description
Summary:Objectives: To describe the differences in clinical presentation and relative disease burden of congenital Zika syndrome (CZS)-associated microcephaly at 2 large hospitals in Salvador, Brazil that serve patients of different socioeconomic status (SES). Methods: Clinical and serologic data were collected prospectively from pregnant women and their infants, who delivered at 2 study centers during the 2015–2016 Zika virus (ZIKV) epidemic in Salvador, Brazil. Results: Pregnant women from Salvador, Brazil delivering in a low SES hospital had 3 times higher ZIKV exposure rate than women at a high SES hospital. However, different SES hospitals had similar prevalence of infants with CZS-associated microcephaly (10% vs 6%, p = 0.16) after controlling for ZIKV exposure in their mothers. Conclusions: Our study supports the positive association between low SES, high maternal ZIKV exposure, and high rates of CZS-associated microcephaly.
ISSN:1201-9712

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