A new peripheral endothelial function measurement improves prediction of symptomatic coronary artery disease
Objective This study aimed to determine whether a peripheral artery volume (PAV) test can improve the predictive value of the age-adjusted Framingham risk score (AFRS) for coronary artery disease (CAD) in symptomatic patients. Methods A total of 317 consecutive patients who were referred for coronar...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
SAGE Publishing
2020-06-01
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| Series: | Journal of International Medical Research |
| Online Access: | https://doi.org/10.1177/0300060520932818 |
| _version_ | 1818920323575185408 |
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| author | Beibei Du Daoyuan Si Dong Zhao Yanan Zhao Kenji Wagatsuma Yuquan He Ping Yang |
| author_facet | Beibei Du Daoyuan Si Dong Zhao Yanan Zhao Kenji Wagatsuma Yuquan He Ping Yang |
| author_sort | Beibei Du |
| collection | DOAJ |
| description | Objective This study aimed to determine whether a peripheral artery volume (PAV) test can improve the predictive value of the age-adjusted Framingham risk score (AFRS) for coronary artery disease (CAD) in symptomatic patients. Methods A total of 317 consecutive patients who were referred for coronary angiography were prospectively enrolled. Before cardiac catheterization, a PAV test was performed to measure changes in pulsatile blood flow volume following reactive hyperemia. Results PAV was significantly lower in patients with CAD than in those without CAD (1.21 ± 0.32 vs. 1.50 ± 0.45). Multivariate logistic regression analysis showed that PAV and the AFRS were independent predictors of CAD. Pairwise comparison of receiver operating characteristic curves showed that the predictive power for CAD increased when PAV was incorporated into the AFRS (area under the curve: from 0.76 to 0.80). The net reclassification index was also improved when PAV was added to the AFRS (0.65, 95% confidence interval: 0.44–0.85). Conclusions Digital endothelial function measurement is an independent predictor of CAD. PAV is potentially useful for identifying patients at high risk for CAD. |
| first_indexed | 2024-12-20T01:19:56Z |
| format | Article |
| id | doaj.art-92822162c88d4565ad7436f1874d9f34 |
| institution | Directory Open Access Journal |
| issn | 1473-2300 |
| language | English |
| last_indexed | 2024-12-20T01:19:56Z |
| publishDate | 2020-06-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Journal of International Medical Research |
| spelling | doaj.art-92822162c88d4565ad7436f1874d9f342022-12-21T19:58:28ZengSAGE PublishingJournal of International Medical Research1473-23002020-06-014810.1177/0300060520932818A new peripheral endothelial function measurement improves prediction of symptomatic coronary artery diseaseBeibei DuDaoyuan SiDong ZhaoYanan ZhaoKenji WagatsumaYuquan HePing YangObjective This study aimed to determine whether a peripheral artery volume (PAV) test can improve the predictive value of the age-adjusted Framingham risk score (AFRS) for coronary artery disease (CAD) in symptomatic patients. Methods A total of 317 consecutive patients who were referred for coronary angiography were prospectively enrolled. Before cardiac catheterization, a PAV test was performed to measure changes in pulsatile blood flow volume following reactive hyperemia. Results PAV was significantly lower in patients with CAD than in those without CAD (1.21 ± 0.32 vs. 1.50 ± 0.45). Multivariate logistic regression analysis showed that PAV and the AFRS were independent predictors of CAD. Pairwise comparison of receiver operating characteristic curves showed that the predictive power for CAD increased when PAV was incorporated into the AFRS (area under the curve: from 0.76 to 0.80). The net reclassification index was also improved when PAV was added to the AFRS (0.65, 95% confidence interval: 0.44–0.85). Conclusions Digital endothelial function measurement is an independent predictor of CAD. PAV is potentially useful for identifying patients at high risk for CAD.https://doi.org/10.1177/0300060520932818 |
| spellingShingle | Beibei Du Daoyuan Si Dong Zhao Yanan Zhao Kenji Wagatsuma Yuquan He Ping Yang A new peripheral endothelial function measurement improves prediction of symptomatic coronary artery disease Journal of International Medical Research |
| title | A new peripheral endothelial function measurement improves prediction of symptomatic coronary artery disease |
| title_full | A new peripheral endothelial function measurement improves prediction of symptomatic coronary artery disease |
| title_fullStr | A new peripheral endothelial function measurement improves prediction of symptomatic coronary artery disease |
| title_full_unstemmed | A new peripheral endothelial function measurement improves prediction of symptomatic coronary artery disease |
| title_short | A new peripheral endothelial function measurement improves prediction of symptomatic coronary artery disease |
| title_sort | new peripheral endothelial function measurement improves prediction of symptomatic coronary artery disease |
| url | https://doi.org/10.1177/0300060520932818 |
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