Structural basis of sequence-specific RNA recognition by the antiviral factor APOBEC3G
Interaction between APOBEC3G and RNA is critical for its antiviral function. Here, the authors report four co-crystal structures of rhesus macaque APOBEC3G and RNA, demonstrating unpaired AA and GA dinucleotide motifs are preferentially recognized.
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Format: | Article |
Language: | English |
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Nature Portfolio
2022-12-01
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Series: | Nature Communications |
Online Access: | https://doi.org/10.1038/s41467-022-35201-9 |
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author | Hanjing Yang Kyumin Kim Shuxing Li Josue Pacheco Xiaojiang S. Chen |
author_facet | Hanjing Yang Kyumin Kim Shuxing Li Josue Pacheco Xiaojiang S. Chen |
author_sort | Hanjing Yang |
collection | DOAJ |
description | Interaction between APOBEC3G and RNA is critical for its antiviral function. Here, the authors report four co-crystal structures of rhesus macaque APOBEC3G and RNA, demonstrating unpaired AA and GA dinucleotide motifs are preferentially recognized. |
first_indexed | 2024-04-11T14:16:01Z |
format | Article |
id | doaj.art-928428a38367414cb412947ff0c92d12 |
institution | Directory Open Access Journal |
issn | 2041-1723 |
language | English |
last_indexed | 2024-04-11T14:16:01Z |
publishDate | 2022-12-01 |
publisher | Nature Portfolio |
record_format | Article |
series | Nature Communications |
spelling | doaj.art-928428a38367414cb412947ff0c92d122022-12-22T04:19:25ZengNature PortfolioNature Communications2041-17232022-12-0113111510.1038/s41467-022-35201-9Structural basis of sequence-specific RNA recognition by the antiviral factor APOBEC3GHanjing Yang0Kyumin Kim1Shuxing Li2Josue Pacheco3Xiaojiang S. Chen4Molecular and Computational Biology, Departments of Biological Sciences and ChemistryMolecular and Computational Biology, Departments of Biological Sciences and ChemistryMolecular and Computational Biology, Departments of Biological Sciences and ChemistryMolecular and Computational Biology, Departments of Biological Sciences and ChemistryMolecular and Computational Biology, Departments of Biological Sciences and ChemistryInteraction between APOBEC3G and RNA is critical for its antiviral function. Here, the authors report four co-crystal structures of rhesus macaque APOBEC3G and RNA, demonstrating unpaired AA and GA dinucleotide motifs are preferentially recognized.https://doi.org/10.1038/s41467-022-35201-9 |
spellingShingle | Hanjing Yang Kyumin Kim Shuxing Li Josue Pacheco Xiaojiang S. Chen Structural basis of sequence-specific RNA recognition by the antiviral factor APOBEC3G Nature Communications |
title | Structural basis of sequence-specific RNA recognition by the antiviral factor APOBEC3G |
title_full | Structural basis of sequence-specific RNA recognition by the antiviral factor APOBEC3G |
title_fullStr | Structural basis of sequence-specific RNA recognition by the antiviral factor APOBEC3G |
title_full_unstemmed | Structural basis of sequence-specific RNA recognition by the antiviral factor APOBEC3G |
title_short | Structural basis of sequence-specific RNA recognition by the antiviral factor APOBEC3G |
title_sort | structural basis of sequence specific rna recognition by the antiviral factor apobec3g |
url | https://doi.org/10.1038/s41467-022-35201-9 |
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